Cannabidiol rescues glutamatergic, memory and social interaction deficits following prenatal infection: a follow-up in female offspring

Effect of cannabidiol on muscarinic neurotransmission in the pre-frontal cortex and hippocampus of the poly I:C rat model of schizophrenia

“…We previously reported that male poly I:C offspring exhibit significantly reduced working memory (decreased percentage of correct entries in the T Maze), recognition memory (decreased Discrimination Ratio in the Novel Object Recognition Test) and social interaction (decreased Total Interaction Time in the Social Interaction test) compared to controls, whereas CBD treated these deficits [7]. We have also previously shown that the female poly I:C offspring had reductions in the Discrimination Ratio and Total Interaction Time that were treated using CBD, but unlike males, working memory performance in the T Maze test was not altered by poly I:C or CBD [17]. In the present study, we examined alterations to markers of cholinergic muscarinic neurotransmission in the PFC and HPC of the brain tissue from those rodents.…”

“…In particular, we found that male poly I:C offspring had deficits in recognition and working memory (assessed using the Novel Object Recognition (NOR) and T Maze tests, respectively), as well as reduced social interaction during the Social Interaction test, while CBD treated these deficits [7]. In female offspring, the poly I:C group exhibited deficits in recognition memory and social interaction that were treated using CBD, while female poly IC offspring did not exhibit impaired working memory [17]. However, the mechanisms by which CBD treats cognitive deficits in the poly I:C model are unknown.…”

“…Treatment began on postnatal day 56, which equates to late adolescence/early adulthood in humans [29]. After 2-weeks of treatment, rats were submitted to a series of behavioural tests, including the Novel object recognition (NOR) test, Rewarded T-maze alternation test and the Social interaction test to assess the effects of CBD on recognition memory, working memory and sociability, respectively [7,17]. The behavioural data were published elsewhere [7,17].…”

“…After 2-weeks of treatment, rats were submitted to a series of behavioural tests, including the Novel object recognition (NOR) test, Rewarded T-maze alternation test and the Social interaction test to assess the effects of CBD on recognition memory, working memory and sociability, respectively [7,17]. The behavioural data were published elsewhere [7,17]. In order to examine the mechanisms by which CBD treated the cognitive deficits in poly I:C offspring, the brain tissue from our previous studies [7,17] was analysed in the present study.…”

“…The behavioural data were published elsewhere [7,17]. In order to examine the mechanisms by which CBD treated the cognitive deficits in poly I:C offspring, the brain tissue from our previous studies [7,17] was analysed in the present study.…”