Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

Chagas, Marcos Hortes Nisihara; Éckeli, Alan Luiz; Zuardi, Antônio Waldo; Pena-Pereira, Márcio Alexandre; Sobreira-Neto, Manoel Alves; Sobreira, Emmanuelle Tavares Alves; Camilo, Millene Rodrigues; Bergamaschi, Mateus M.; Schenck, Carlos H.; Hallak, Jaime Eduardo Cecílio; Tumas, Vítor; Crippa, José Alexandre S

doi:10.1111/jcpt.12179

Cited by 197 publications

(128 citation statements)

References 24 publications

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“…It is interesting to note that another cannabinoid receptor agonist, cannabidiol, has recently been found to effectively control the disturbing dreams/nightmares -i.e., hallucinations during REM sleep--and associated abnormal parasomnia behaviors -viz. dream-enacting behaviors -emerging with REM sleep behavior disorder in patients with Parkinson's disease (Chagas, 2014; and personal communication with Carlos H. Schenck).…”

Section: Evidence For Psychoactive Plant Use In Prr In Greek-hellenicmentioning

confidence: 99%

The Consumption of Psychoactive Plants in Ancient Global and Anatolian Cultures During Religious Rituals: The Roots of the Eruption of Mythological Figures and Common Symbols in Religions and Myths

Sayin

2014

Neuroquantology

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Psychoactive plants which contain hallucinogenic molecules that induce a form of altered states of consciousness (H-ASC) have been widely used during the religious rituals of many cultures throughout the centuries, while the consumption of these plants for spiritual and religious purposes is as old as human history. Some of those cultures were shaman and pagan subcultures; African native religions; Bwiti Cult; South American native religions; Amazon Cultures; Central American Cultures; Mexican subcultures; Aztec, Maya and Inca; Wiccan and witch subcultures; Satanists; American Indians; Greek and Hellenistic cultures; Sufis; Hassan Sabbah's Hashissins; Hindu, Indian and Tibetan cultures; some of the Nordic subcultures etc. Some of the psychoactive ingredients of the plants that were used during these religious rituals were; narcotic analgesics (opium), THC (cannabis), psilocybin (magic mushrooms), mescaline (peyote), ibogaine (Tabernanthe iboga), DMT (Ayahuasca and phalaris species), Peganum harmala, bufotenin, muscimol (Amanita muscaria), thujone (absinthe, Arthemisia absinthium), ephedra, mandragora, star lotus, Salvia divinorum etc. The main purposes of the practice of these plants were: spiritual healing; to contact with spirits; to contact with the souls of ancestors; to reach enlightenment (Nirvana or Satori); to become a master shaman, pagan or witch; to reach so-called-other realities, etc. Such "psychedelic-philosophical plant rituals" changed participating persons' psychology, philosophy and personality to a great degree. In these two successive articles, the consumption of psychedelic plants during religious rituals is reviewed and it is hypothesized that the images, figures, illusions and hallucinations experienced during these "plant trips" had a great impact on the formation and creation of many figures, characters, creatures, archetype images that exist not only in the mythology, but also in many religions, as well, such as angels, demons, Satan, mythological creatures, gods, goddesses etc. In the Middle East and Anatolia, within many hermetic and pagan religions, Greek and Hellenic cultures psychoactive plant use was a serious part of the religious rituals, such as Dionysian rituals or Witch's' Sabbaths. Although the impact of the "psychedelic experience and imagination" was enormous to the configuration of many religious and mythological characters, and archetypes, this fact has been underestimated and even unnoticed by many historians and anthropologists, because of the quasi-ethical trends of "anti-drug-brain-washed Western Societies".

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Section: Evidence For Psychoactive Plant Use In Prr In Greek-hellenicmentioning

confidence: 99%

The Consumption of Psychoactive Plants in Ancient Global and Anatolian Cultures During Religious Rituals: The Roots of the Eruption of Mythological Figures and Common Symbols in Religions and Myths

Sayin

2014

Neuroquantology

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“…Other agents with efficacy based on limited case reports include imipramine, desipramine, carbamazepine, levodopa, Yi-Gan San, sodium oxybate, triazolam, zopiclone, quetiapine, clozapine, and cannabidiol [3,74,82].…”

Section: Other Agentsmentioning

confidence: 99%

Rapid Eye Movement Sleep Behavior Disorder: Overview and Current Perspective

Irfan

Howell

2016

Curr Sleep Medicine Rep

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Rapid eye movement (REM) stage of sleep in normal circumstances is composed of vivid dream mentation associated with physiological skeletal muscle paralysis and thus, quiescence of motor activity. REM sleep behavior disorder (RBD) is a parasomnia characterized by disinhibition of motor control facilitating dream enactment behaviors. These nocturnal motoric behaviors due to lack of REM atonia range from benign limb movements to complex aggressive actions but are often manifested by violent, aggressive flailing, punching and kicking with vocalizations enacting action-filled hostile dreams. Polysomnographic evidence of increased electromyographic tone during REM with or without capturing clinical dream enactment together with careful history helps diagnose RBD. It is considered a prodromal feature of neurodegenerative alpha-synucleinopathies with high rate of eventual phenoconversion. The mainstay of treatment is to first ensure physical safety. When medications are necessary, options include either low-dose clonazepam, high-dose melatonin or both. Yearly surveillance with detailed neurological evaluation is vital for early detection and eventual management of neurodegenerative disorder.

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“…O CBD poderia ter um efeito terapêutico sobre os sintomas do transtorno comportamental do sono REM 12 .…”

Section: Canabinoides Na Doença De Parkinson E Em Outros Distúrbios Dunclassified

“…O uso terapêutico sem indicação precisa só seria indicado em casos de distúrbios do movimento em que os tratamentos convencionais disponíveis falharam, e a qualidade de vida do paciente esteja muito comprometida. É provável que o uso de CBD puro e extratos de cannabis com baixo teor de THC sejam os mais eficientes e menos propensos a causar efeitos indesejáveis 12 .…”

Section: Canabinoides Na Doença De Parkinson E Em Outros Distúrbios Dunclassified

Cannabinoids in neurology – Brazilian Academy of Neurology

Brucki

Frota

Schestatsky

et al. 2015

Arq. Neuro-Psiquiatr.

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ASPECTOS GERAISRecentemente o uso de canabidiol foi liberado para prescrição aos médicos do Estado de São Paulo, pelo Cremesp (Conselho Regional de Medicina do Estado de São Paulo), em 9 de outubro de 2014. A ANVISA já liberou o seu uso medicinal por importação para vários casos; exige-se a prescrição e laudo médicos e termo de responsabilidade. Cada vez mais o uso terapêutico dos canabinoides têm sido discutidos. A Academia Brasileira de Neurologia através de seus Departamentos Científicos tomou sua posição de acordo com as evidências científicas sobre o uso dos canabinoides nas devidas doenças neurológicas.Os canabinoides mais exuberantes são o Δ9-tetrahidrocanabinol (THC) que possui propriedades psicoativas e o canabidiol (CBD), que não tem propriedades psicoativas. Existem no sistema nervoso central os endocanabinoides, sendo dois tipos mais abundantes: o 2-arachydonoyl glycerol e o n-arachidonoyl ethanolamide. Eles são liberados em resposta à atividade sináptica excitatória, sendo sintetizados no corpo e dendritos dos neurônios, em resposta ao aumento da concentração de cálcio intracelular. Inibem a liberação de neurotransmissores pela via final em terminais gabaérgicos e em menor extensão, glutamatérgicos. Agem em vários mecanismos de plasticidade de curto e longo prazo de sinapses inibitórias e excitatórias. Várias áreas cerebrais são ricas em receptores CB1, como o córtex frontal, os núcleos da base, cerebelo e na região límbica cerebral. Por estes mecanismos podem ter ação em várias doenças neurológicas 1,2,3,4 . EFEITOS COGNITIVOSO uso de cannabis na forma inalada, por indivíduos saudá-veis, está associado a pior desempenho cognitivo, seja de forma aguda ou crônica. A suspensão do seu uso reverte parcialmente RESumO O uso do canabidiol em algumas condições neurológicas foi liberado pelo Conselho Regional de Medicina de São Paulo e pela Agência Nacional de Vigilância Sanitária (ANVISA). Especialistas em nome da Academia Brasileira de Neurologia prepararam uma posição crítica sobre o uso do canabidiol e outros derivados da cannabis em doenças neurológicas.Palavras-chave: canabidiol, doenças neurológicas, esclerose múltipla, epilepsia, dor, doença de Parkinson. ABSTRACTThe use of cannabidiol in some neurological conditions was allowed by Conselho Regional de Medicina de São Paulo and by Agência Nacional de Vigilância Sanitária (ANVISA). Specialists on behalf of Academia Brasileira de Neurologia prepared a critical statement about use of cannabidiol and other cannabis derivatives in neurological diseases.

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Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

Abstract: This case series indicates that CBD is able to control the symptoms of RBD.

Cited by 197 publications

References 24 publications

The Consumption of Psychoactive Plants in Ancient Global and Anatolian Cultures During Religious Rituals: The Roots of the Eruption of Mythological Figures and Common Symbols in Religions and Myths

The Consumption of Psychoactive Plants in Ancient Global and Anatolian Cultures During Religious Rituals: The Roots of the Eruption of Mythological Figures and Common Symbols in Religions and Myths

Rapid Eye Movement Sleep Behavior Disorder: Overview and Current Perspective

Cannabinoids in neurology – Brazilian Academy of Neurology

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