Canine Mast Cell Tumors

Macy, Dennis W.

doi:10.1016/s0195-5616(85)50036-4

Cited by 52 publications

(99 citation statements)

References 36 publications

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“…The survival time of dogs with multiple MCTs was not significantly different to dogs with solitary tumors. Multiple tumors were more prevalent in this study than previously reported in the literature (3-14% from Macy, 1985;O'Keefe, 1990;Simoes et al, 1994).…”

Section: Discussioncontrasting

confidence: 52%

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Mackowiak

Gentile

Chaible

et al. 2012

The Veterinary Journal

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Section: Discussioncontrasting

confidence: 52%

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Mackowiak

Gentile

Chaible

et al. 2012

The Veterinary Journal

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“…2,12,21,25,27,34 Moreover, the mean age of the affected animals and the location of the lesions, particularly on the trunk and perineal region, closely followed the veterinary literature. 12,16,21,34 However, the incidence of multiple MCTs in the present study was slightly higher (20%) than that reported in the veterinary literature (3-14%). 1,21,33 Despite the fact that several methods have been evaluated as prognostic indicators of canine cutaneous MCTs, no single method is more widely used than conventional histologic grading, 16,21,22,25,34 which is based on morphologic characteristics.…”

Section: Discussionmentioning

confidence: 73%

“…8,32 Therefore, cytopathology is an important technique in the diagnosis of mast cell neoplasia. 21,25 Sampling lesions and preparing, fixing, and staining smears can be accomplished within 30 min with Romanowsky-type stains, and the final diagnosis can made rapidly thereafter. 4,32,35 Using cytologic preparations, cells have less alteration of their morphology related to fixation and staining.…”

Section: Discussionmentioning

confidence: 99%

Nuclear Morphometry in Cytopathology: A Prognostic Indicator for Canine Cutaneous Mast Cell Tumors

et al. 2009

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Abstract. Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high-and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

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“…18 Grade is often predictive of biologic behavior, with grade I tumors behaving in a benign fashion and grade III tumors tending to follow a highly malignant course. 5,18,19,22,28,30 Many grade II tumors are treated successfully with surgical resection followed by local radiation therapy as needed, but there exists a subset of grade II tumors that spread to local lymph nodes as well as distant sites such as the spleen, liver, and internal lymph nodes, eventually leading to death of the affected patient. 18 Predicting the behavior of grade II MCTs has proven to be difficult, and this problem is confounded by the fact that despite specific guidelines for determination of grade (i.e., the Patnaik system), there is significant variation in grade assignment among pathologists.…”

Section: Discussionmentioning

confidence: 99%

“…Those patients with grade I tumors are likely to experience long-term survival, while those with grade III tumors have a reported median survival time of only 6 months. 5,18,19,22,28,30 Although most grade II MCTs are considered benign, a proportion of these will metastasize to local lymph nodes and distant sites. 18 While tumor grade is often used to determine prognosis, there is widespread disagreement on standardization of grading, as evidenced by a recent publication in which there was significant variation among 10 pathologists in the grading of the same set of 60 MCTs.…”

mentioning

confidence: 99%

Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

et al. 2007

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Abstract. Mitotic index (MI) is an indirect measure of cell proliferation that has been demonstrated to be a strong predictor of outcome for several human and canine cancers. The purpose of this study was to evaluate the utility of MI as a predictor of biologic behavior and survival in dogs with cutaneous mast cell tumors (MCTs). Medical records from 148 dogs with histologically confirmed MCTs were reviewed. Information regarding tumor grade, local recurrence, metastatic disease, date of death/last follow-up, and outcome was obtained. The region of the tumor with the highest overall mitotic activity was chosen for evaluation, and the MI value was defined as the number of mitotic figures/10 high-power fields (4003, 2.7 mm 2 ). A Cox proportional hazards regression model was used to compare MI with survival data. A Mann-Whitney test was used to compare MI on the basis of the development of local recurrence and metastatic disease. The MI correlated directly with tumor grade (P , .0001). The median survival time for dogs with an MI #5 was significantly longer (70 months) than for those with an MI .5 (2 months), regardless of grade (P , .001). For grade II tumors with an MI #5, the median survival time (MST) was 70 months, compared with 5 months for those with an MI .5 (P , .001). For grade III tumors with an MI #5, the MST was not reached, compared with ,2 months for those with an MI .5 (P , .001). In conclusion, MI is a strong predictor of overall survival for dogs with cutaneous MCTs and should be included as a prognostic indicator when determining therapeutic options.

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Canine Mast Cell Tumors

Cited by 52 publications

References 36 publications

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Nuclear Morphometry in Cytopathology: A Prognostic Indicator for Canine Cutaneous Mast Cell Tumors

Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

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