Canine Mast Cell Tumors

O'Keefe, Deborah A.

doi:10.1016/s0195-5616(90)50087-x

Cited by 64 publications

(51 citation statements)

References 14 publications

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“…It has been observed that animals >9 years are more likely to be affected with tumor recurrence and death, and these results agree with the findings reported by Cahalane et al (2004). Our results regarding anatomical site of MCTs also confirm previously published data showing that the most common sites are the chest and perineum, followed by the distal parts of the limbs and the head and neck (O'Keefe, 1990;Fox, 1998).…”

Section: Discussionsupporting

confidence: 92%

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E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Mackowiak

Gentile

Chaible

et al. 2012

The Veterinary Journal

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Section: Discussionsupporting

confidence: 92%

“…The survival time of dogs with multiple MCTs was not significantly different to dogs with solitary tumors. Multiple tumors were more prevalent in this study than previously reported in the literature (3-14% from Macy, 1985;O'Keefe, 1990;Simoes et al, 1994).…”

Section: Discussioncontrasting

confidence: 53%

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Mackowiak

Gentile

Chaible

et al. 2012

The Veterinary Journal

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“…Therefore, the estimation of prognosis and treatment plans can be difficult. Treatment may consist of surgery, radiotherapy, chemotherapy, or a combination of these modalities [12]. Chemotherapy is applied to tumor-bearing patients in cases of failed surgery and radiotherapy.…”

mentioning

confidence: 99%

Immunohistochemical Detection of P-Glycoprotein (PGP) and Multidrug Resistance-Associated Protein (MRP) in Canine Cutaneous Mast Cell Tumors.

Miyoshi

Tojo

Oishi

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. Fifty-four canine cutaneous mast cell tumors were evaluated immunohistochemically for the expression of P-glycoprotein (PGP) and multidrug-resistance-associated protein (MRP). All tumors examined were graded according to the histological malignancy, ranging from grade I to III. The expression of PGP was confirmed in 15% (8/54) of whole, 33% (5/15) of grade I, 10% (3/31) of grade II, and 0% (0/8) of grade III tumors. The expression of MRP was found in 18% (10/54) of whole, 26% (4/15) of grade I, 19% (6/31) of grade II, and 0% (0/8) of grade III tumors. The cases positive to at least one of these 2 multidrug markers were 26%, 47%, 23% and 0% of whole and grade I to III tumors, respectively. These results indicate that at least 26% of canine cutaneous mast cell tumors express PGP and/or MRP and that these tumors may be resistant to several anti-cancer drugs. KEY WORDS: canine, mast cell tumor, multidrug resistance.

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“…However, profound icterus observed in our case has not been reported previously. Coagulopathy, which may be associated with heparin release from mast cells, has been reported in canine MCT [8,12,13]. However, thrombocytopenia and marked hemolysis observed in our case are not common in dogs with systemic MCT.…”

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confidence: 43%

“…These tumor cells were identical to those found in the peripheral blood. Furthermore, tissue sections were stained with alcian bluesafranin, and with berberine sulfate, which is a fluorescent dye that specifically stains heparin, according to the method Visceral mast cell tumor (MCT) and mast cell leukemia are rare in dogs in contrast to cats [10,12]. Several reports are available on mast cell leukemia associated with systemic MCT in dogs [1,2,6,8,13,15,17].…”

mentioning

confidence: 99%

Connective Tissue-Type Mast Cell Leukemia in a Dog.

Hikasa

Morita

Futaoka

et al. 2000

The Journal of Veterinary Medical Science

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ABSTRACT. An unusual case diagnosed as connective tissue-type mast cell leukemia with marked mastocyte infiltration into visceral organs in a seven-year-old female Curly-Coated retriever is presented. Acute circulatory collapse, emesis, diarrhea, abdominal enlargement, icterus, cyanosis, dyspnea, pulmonary edema, hepatomegary, ascites, and right ventricular enlargement were observed. Hematologic and biochemical examinations revealed mast cell leukemia, mature neutrophilia, monocytosis, thrombocytopenia, hemolytic hyperbilirubinemia, hyperhistaminemia, renal and hepatic injuries. Mast cells were distributed systemically, but predominantly in the diaphragm and liver with a large mass among the serosa of ileum, cecum and colon. Mast cells were stained intensely by both safranin and berberine sulfate.-KEY WORDS: canine mast cell leukemia, connective tissue type, visceral mast cell tumor.J. Vet. Med. Sci. 62(2): 187-190, 2000 gravity and pH were 1.035 and 6.0 respectively. Serum biochemical findings revealed marked renal injury and hemolytic hyperbilirubinemia (Table 1). Serum protein electrophoresis was within normal limits. Later, plasma histamine concentrations of this case were found to be approximately 1,000-folds higher than those of two normaladult beagle dogs (0.45 and 0.49 ng/ml). Venous blood gas and serum electrolyte analyses showed profound metabolic alkalosis, hypokalemia and hypochrolidemia (Table 1). At this time, the dog was diagnosed as having mast cell leukemia, and treated with dexamethasone, cimetidine, aminophylline, ampicillin and fluid. However, the dog died on day 2 and was then necropsied.Gross examination revealed a large mass measuring 16.5 × 13.0 × 5.0 cm among the serosa of the ileum, cecum and colon. The mass was coarsely rough on the surface, encapsulated and irregularly lobulated with grayish white necrotic and hemorrhagic areas on the cut surface (Fig. 2). The liver was swollen with irregular whitish discoloration, and ascites was very evident. The cardiac right ventricle was dilated, and the lung was diffusely congested; the tracheobronchial lymph nodes were enlarged. Gastroduodenal ulcer, congestion and hemorrhage were also observed.Histologically, neoplastic mast cells were determined in the mass. They were also distributed predominantly in the diaphragm and liver, mildly in the spleen and bone marrow, minimally in the heart, lung, kidney, adrenal gland, urinary bladder and uterus. The tumor cells had cytoplasm containing small to large granules that were stained metachromatically with toluidine blue. These tumor cells were identical to those found in the peripheral blood. Furthermore, tissue sections were stained with alcian bluesafranin, and with berberine sulfate, which is a fluorescent dye that specifically stains heparin, according to the method Visceral mast cell tumor (MCT) and mast cell leukemia are rare in dogs in contrast to cats [10,12]. Several reports are available on mast cell leukemia associated with systemic MCT in dogs [1,2,6,8,13,15,17]. However, reports on cli...

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Canine Mast Cell Tumors

Cited by 64 publications

References 14 publications

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors

Immunohistochemical Detection of P-Glycoprotein (PGP) and Multidrug Resistance-Associated Protein (MRP) in Canine Cutaneous Mast Cell Tumors.

Connective Tissue-Type Mast Cell Leukemia in a Dog.

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