2016
DOI: 10.1371/journal.pone.0157242
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Abstract: Fungal infections, especially those caused by antibiotic resistant pathogens, have become a serious public health problem due to the growing number of immunocompromised patients, including those subjected to anticancer treatment or suffering from HIV infection. In this study we assessed fungicidal activity of the ceragenins CSA-13, CSA-131 and CSA-192 against four fluconazole–resistant Candida strains. We found that ceragenins activity against planktonic Candida cells was higher than activity of human LL-37 pe… Show more

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Cited by 64 publications
(66 citation statements)
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“…Antifungal activities of AMPs have been reported, [49,72] and as mimics of AMPs, ceragenins were anticipated to have antifungal activities. Bucki et al [24] determined the antifungal activities of ceragenins CSA-13, CSA-131 and CSA-192 and compared these to those of LL-37, a synthetic, anti-fungal AMP (omiganan) and commonly-used antifungal agents amphotericin B and fluconazole. MICs and minimum fungicidal concentrations (MFCs) for clinical isolates of C. albicans are given in Table 2.…”
Section: Anti-fungal Activitymentioning
confidence: 99%
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“…Antifungal activities of AMPs have been reported, [49,72] and as mimics of AMPs, ceragenins were anticipated to have antifungal activities. Bucki et al [24] determined the antifungal activities of ceragenins CSA-13, CSA-131 and CSA-192 and compared these to those of LL-37, a synthetic, anti-fungal AMP (omiganan) and commonly-used antifungal agents amphotericin B and fluconazole. MICs and minimum fungicidal concentrations (MFCs) for clinical isolates of C. albicans are given in Table 2.…”
Section: Anti-fungal Activitymentioning
confidence: 99%
“…Bone morphogenetic protein-2 (BMP-2) is used clinically to accelerate bone regrowth, [93] and Schindeler et al [24] investigated whether ceragenins would impact bone regrowth alone and in combination with BMP-2. A series of ceragenins were tested for their impacts on bone regrowth, and they found that CSA-90 displayed the most potent activity.…”
Section: Ceragenins In Bone Fracturesmentioning
confidence: 99%
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“…2014; Durnas et al. 2016). Therefore, LL-37 can kill C. albicans rapidly by binding and destabilizing the cell membrane (den Hertog et al.…”
Section: Direct Mechanisms Of Actionmentioning
confidence: 99%
“…2014; Durnas et al. 2016). After LL-37 action, C. albicans cell membrane is fragmented into a series of adjacent vesicle-like structures of ∼100 nm, with exposed inner and outer leaflets (den Hertog et al.…”
Section: Direct Mechanisms Of Actionmentioning
confidence: 99%