Candida chorioretinitis in renal transplant recipient with candidemia related to contaminated organ preservation fluid: A role for dilated fundus examination in its management

Schils, Raphaël; Rampat, Radhika; Rakic, Jean-Marie; Crahay, François-Xavier

doi:10.1016/j.idcr.2023.e01793

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Candidemias represent a significant healthcare challenge, ranking among the foremost causes of morbidity and mortality, particularly in patients with healthcare-associated infections (HAI) [1][2][3][4][5]. Invasive candidiasis (IC) accounts for over 95% of these infections, with Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei, and, in certain regions, Candida auris being the primary culprits.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

Contreras-Martínez,

Angulo-Ortíz,

Santafé-Patiño

et al. 2023

JoF

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Candida tropicalis, an opportunistic pathogen, ranks among the primary culprits of invasive candidiasis, a condition notorious for its resistance to conventional antifungal drugs. The urgency to combat these drug-resistant infections has spurred the quest for novel therapeutic compounds, with a particular focus on those of natural origin. In this study, we set out to evaluate the impact of isoespintanol (ISO), a monoterpene derived from Oxandra xylopioides, on the transcriptome of C. tropicalis. Leveraging transcriptomics, our research aimed to unravel the intricate transcriptional changes induced by ISO within this pathogen. Our differential gene expression analysis unveiled 186 differentially expressed genes (DEGs) in response to ISO, with a striking 85% of these genes experiencing upregulation. These findings shed light on the multifaceted nature of ISO’s influence on C. tropicalis, spanning a spectrum of physiological, structural, and metabolic adaptations. The upregulated DEGs predominantly pertained to crucial processes, including ergosterol biosynthesis, protein folding, response to DNA damage, cell wall integrity, mitochondrial activity modulation, and cellular responses to organic compounds. Simultaneously, 27 genes were observed to be repressed, affecting functions such as cytoplasmic translation, DNA damage checkpoints, membrane proteins, and metabolic pathways like trans-methylation, trans-sulfuration, and trans-propylamine. These results underscore the complexity of ISO’s antifungal mechanism, suggesting that it targets multiple vital pathways within C. tropicalis. Such complexity potentially reduces the likelihood of the pathogen developing rapid resistance to ISO, making it an attractive candidate for further exploration as a therapeutic agent. In conclusion, our study provides a comprehensive overview of the transcriptional responses of C. tropicalis to ISO exposure. The identified molecular targets and pathways offer promising avenues for future research and the development of innovative antifungal therapies to combat infections caused by this pathogenic yeast.

show abstract

Section: Introductionmentioning

confidence: 99%

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

Contreras-Martínez,

Angulo-Ortíz,

Santafé-Patiño

et al. 2023

JoF

View full text Add to dashboard Cite

show abstract

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

Contreras Martínez,

Angulo Ortíz,

Santafé Patiño

et al. 2023

Preprint

View full text Add to dashboard Cite

Candida tropicalis, an opportunistic pathogen, ranks among the primary culprits of invasive candidiasis, a condition notorious for its resistance to conventional antifungal drugs. The urgency to combat these drug-resistant infections has spurred the quest for novel therapeutic compounds, with a particular focus on those of natural origin. In this study, we set out to evaluate the impact of Isoespintanol (ISO), a monoterpene derived from Oxandra xylopioides, on the transcriptome of C. tropicalis. Leveraging transcriptomics, our research aimed to unravel the intricate transcriptional changes induced by ISO within this pathogen. Our differential gene expression analysis unveiled 186 differentially expressed genes (DEGs) in response to ISO, with a striking 85% of these genes experiencing upregulation. These findings shed light on the multifaceted nature of ISO's influence on C. tropicalis, spanning a spectrum of physiological, structural, and metabolic adaptations. The upregulated DEGs predominantly pertained to crucial processes, including ergosterol biosynthesis, protein folding, response to DNA damage, cell wall integrity, mitochondrial activity modulation, and cellular responses to organic compounds. Simultaneously, 27 genes were observed to be repressed, affecting functions such as cytoplasmic translation, DNA damage checkpoints, membrane proteins, as well as metabolic pathways like trans-methylation, trans-sulfuration, and trans-propylamine. These results underscore the complexity of ISO's antifungal mechanism, suggesting that it targets multiple vital pathways within C. tropicalis. Such complexity potentially reduces the likelihood of the pathogen developing rapid resistance to ISO, making it an attractive candidate for further exploration as a therapeutic agent. In conclusion, our study provides a comprehensive overview of the transcriptional responses of C. tropicalis to ISO exposure. The identified molecular targets and pathways offer promising avenues for future research and the development of innovative antifungal therapies to combat infections caused by this pathogenic yeast.

show abstract

Candida chorioretinitis in renal transplant recipient with candidemia related to contaminated organ preservation fluid: A role for dilated fundus examination in its management

Cited by 2 publications

References 16 publications

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment

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