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Abstract: The history of stem cell research was started in the early 1900s in Europe where the researcher realized that various types of blood cells came from a particular ''stem cells.'' However, it was not until 1963 that the first quantitative description of the self-renewal activities of transplanted mouse bone marrow cells were documented by Canadian scientist Ernest A McCulloch and James E Till in Toronto. The concept of cancer stem cells has been used over 50 years ago; whereas the strong evidence for the existen… Show more

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Cited by 34 publications
(26 citation statements)
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References 49 publications
(26 reference statements)
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“…Such associations have repeatedly been shown for CD44/CD44v (39,40,43,44) and could be shown for ASML wt but not ASML-CD44v rsc cells. We noted an increased association between CD44v6 and c-Src in ASML cells, which was accompanied by increased activation of the focal adhesion kinase, 5 which can trigger PI3K activation. It also has been described that c-met supports tumor cell survival via PI3K/Akt activation (45,46) and that c-met interacts with CD44v6 via hepatocyte growth factor/scatter factor binding (23).…”
Section: Cd44v and Apoptosis Protectionmentioning
confidence: 72%
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“…Such associations have repeatedly been shown for CD44/CD44v (39,40,43,44) and could be shown for ASML wt but not ASML-CD44v rsc cells. We noted an increased association between CD44v6 and c-Src in ASML cells, which was accompanied by increased activation of the focal adhesion kinase, 5 which can trigger PI3K activation. It also has been described that c-met supports tumor cell survival via PI3K/Akt activation (45,46) and that c-met interacts with CD44v6 via hepatocyte growth factor/scatter factor binding (23).…”
Section: Cd44v and Apoptosis Protectionmentioning
confidence: 72%
“…Restoring CD44v expression in ASML-CD44v kd clones suffices to rescue the metastatic potential but not apoptosis 5 T. Jung, unpublished finding. resistance.…”
Section: Cd44v and Apoptosis Protectionmentioning
confidence: 89%
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“…CD44 contributes to HSC-and leukemia-initiating cell homing (4,50), the feature of which is used for HSC mobilization (17,51) and leukemia-initiating cell dislodgment by anti-CD44, driving the latter into differentiation and apoptosis (5,6). Because antiCD49d also promotes HSC and leukemia cell mobilization (16,52), and a CD44-CD49d cooperation additionally supports proliferation and apoptosis resistance (23,53), we assumed that a blockade of both CD44 and CD49d may be a more efficient therapeutic.…”
Section: Discussionmentioning
confidence: 99%