Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Zhou, Weiying; Fong, Miranda; Min, Yongfen; Somlo, George; Liu, Liang; Palomares, Melanie R.; Yu, Yang; Chow, Amy; O’Connor, Sean Timothy Francis; Chin, Andrew R.; Yen, Yun; Wang, Yafan; Marcusson, Eric G.; Chu, Peiguo; Wu, Jun; Wu, Xiwei; Li, Arthur Xuejun; Li, Zhuo; Gao, Hanlin; Ren, Xiubao; Boldin, Mark; Lin, Ping Chang; Wang, Shizhen Emily

doi:10.1016/j.ccr.2014.03.007

Cited by 1,189 publications

(1,084 citation statements)

References 61 publications

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“…miRNAs can be secreted through extracellular vesicles (EVs), such as exosomes, shedding vesicles, and apoptotic bodies, or in complexes with protein or lipid-based carriers [9,10]. Accumulating evidence demonstrates that miRNAs can be transferred via EVs to neighboring or distant cells to modulate cell function [11][12][13][14][15][16][17][18][19]. Extracellular miRNAs are therefore emerging as a new group of messengers and effectors in intercellular communication.…”

Section: Introductionmentioning

confidence: 99%

Cross-kingdom inhibition of breast cancer growth by plant miR159

Fong²,

et al. 2016

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MicroRNAs (miRNAs) are critical regulators of gene expression, and exert extensive impacts on development, physiology, and disease of eukaryotes. A high degree of parallelism is found in the molecular basis of miRNA biogenesis and action in plants and animals. Recent studies interestingly suggest a potential cross-kingdom action of plant-derived miRNAs, through dietary intake, in regulating mammalian gene expression. Although the source and scope of plant miRNAs detected in mammalian specimens remain controversial, these initial studies inspired us to determine whether plant miRNAs can be detected in Western human sera and whether these plant miRNAs are able to influence gene expression and cellular processes related to human diseases such as cancer. Here we found that Western donor sera contained the plant miRNA miR159, whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients. In human sera, miR159 was predominantly detected in the extracellular vesicles, and was resistant to sodium periodate oxidation suggesting the plant-originated 2'-O-methylation on the 3′ terminal ribose. In breast cancer cells but not non-cancerous mammary epithelial cells, a synthetic mimic of miR159 was capable of inhibiting proliferation by targeting TCF7 that encodes a Wnt signaling transcription factor, leading to a decrease in MYC protein levels. Oral administration of miR159 mimic significantly suppressed the growth of xenograft breast tumors in mice. These results demonstrate for the first time that a plant miRNA can inhibit cancer growth in mammals.

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Section: Introductionmentioning

confidence: 99%

Cross-kingdom inhibition of breast cancer growth by plant miR159

Fong²,

et al. 2016

Self Cite

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“…These small non-coding RNAs plays important roles in cancer, 76 explaining why this discovery suggested a new regulatory role for exosomes in cancer. Today, numerous studies have identified different functional exosomal miRNAs and their role in cancer, 77,78 and proposed their use as diagnosis biomarkers. 79,80,81 For example, in lung cancer 2 miRNAs, miR-21 and miR-155 have been found to be significantly upregulated in recurrent tumors compared to primary tumors.…”

Section: Exosomes As Biomarkersmentioning

confidence: 99%

Exosomes in cancer theranostic: Diamonds in the rough

Cordonnier

Chanteloup

Isambert

et al. 2017

Cell Adhesion & Migration

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During the last 10 years, exosomes, which are small vesicles of 50-200 nm diameter of endosomal origin, have aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. Most cells can potentially release these nanovesicles that share with the parent cell a similar lipid bilayer with transmembrane proteins and a panel of enclosed soluble proteins such as heat shock proteins and genetic material, thus acting as potential nanoshuttles of biomarkers. Exosomes surface proteins allow their targeting and capture by recipient cells, while the exosomes' content can modify the physiological state of recipient cells. Tumor derived exosomes by interacting with other cells of the tumor microenvironment modulate tumor progression, angiogenic switch, metastasis, and immune escape. Targeting tumor-derived exosomes might be an interesting approach in cancer therapy. Furthermore, because a key issue to improve cancer patients' outcome relies on earlier cancer diagnosis (metastases, as opposed to the primary tumor, are responsible for most cancer deaths) exosomes have been put forward as promising biomarker candidates for cancer diagnosis and prognosis. This review summarizes the roles of exosomes in cancer and clinical interest, focusing on the importance of exosomal heat shock proteins (HSP). The challenges of clinical translation of HSPexosomes as therapeutic targets and biomarkers for early cancer detection are also discussed.

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“…Multiple studies indicate that exosomes are actually involved in different phases of carcinogenesis and tumor development. [48][49][50][51][52][53][54][55] From the perspective of tumor-initiating property, Melo et al 17 demonstrated that the non-tumorigenic MCF10A cells formed tumor mass in nude mice when co-injected with cancer cell-derived exosomes, and Dicer blocking in these exosomes could reduce tumor formation. This oncogenic conversion of MCF10A cells attributes to precursor microRNAs (pre-miRNAs), along with Dicer, AGO2 (Argonaute2), and TRBP (HIV-1 TAR RNA binding protein) in exosomes of cancer cells.…”

Section: Biological Functions In Tumorigenesismentioning

confidence: 99%

Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell lymphomas: The key role of exosomes

Wang

2017

Tumour Biol.

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B-cell lymphomas are composed of tumor cells and the tumor microenvironment, which is conventionally thought to be composed of a mixture of stromal cells, blood vessels, immune cells, and non-cell components, such as extracellular matrix, cytokines, and chemokines. Exosomes, small endocytically derived vesicles that have been proved to be present in a variety of tumor niches and involved in mediating cell signaling networks, are increasingly regarded as important components of tumor microenvironment. In this review, we first focus on the biogenesis, biodistribution, transportation, and other general characteristics of exosomes and then highlight the vital roles of exosomes in lymphomagenesis and disease progression, particularly from the perspective of immune dysfunction, virus infection, and therapeutic resistance mechanisms.

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Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Cited by 1,189 publications

References 61 publications

Cross-kingdom inhibition of breast cancer growth by plant miR159

Cross-kingdom inhibition of breast cancer growth by plant miR159

Exosomes in cancer theranostic: Diamonds in the rough

Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell lymphomas: The key role of exosomes

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