Cancer prevention by adult‐onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice

Shang, Yi; Kakinuma, Shizuko; Yamauchi, K.; Morioka, Takamitsu; Kokubo, Toshiaki; Tani, Shusuke; Tsuruo, Takashi; Kataoka, Yasushi; Shimada, Yoshiya

doi:10.1002/ijc.28751

Cited by 30 publications

(45 citation statements)

References 46 publications

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“…CR could decelerate the rate of aging and inhibit tumor formation in mammals [72][73][74]. It could also decrease the tumors that were induced by chemicals and IR in rodents and nonhuman primates [70,[75][76][77][78][79][80][81][82][83]. Even after exposure to IR, CR could still be effective for reducing cancer incidence in mice [82,83].…”

Section: Discussionmentioning

confidence: 99%

“…It could also decrease the tumors that were induced by chemicals and IR in rodents and nonhuman primates [70,[75][76][77][78][79][80][81][82][83]. Even after exposure to IR, CR could still be effective for reducing cancer incidence in mice [82,83]. These studies showed that dietary intervention could alter the phenotype and epigenotype in animal models [84], and demonstrated the feasibility of an active means to prevent or reverse the adverse effects from unbalanced diet or malnutrition.…”

Section: Discussionmentioning

confidence: 99%

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Dietary Modification of Mouse Response to Total-Body-Irradiation

Wang¹,

Tanaka²,

Katsube³

et al. 2015

Evolution of Ionizing Radiation Research

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Exposure to ionizing radiation (IR) could induce deleterious effects including cancer. Diet, as one of the major factors to influence susceptibility to many diseases, plays a critical role in maintaining human heath. It is known that unbalanced diet could result in health consequences, for example, high-calorie diet could lead to obesity, which could increase the risk of diabetes, heart disease, fatty liver, and some forms of cancer. Although the impact of diet on susceptibility to IR is thought to be big, the evidence is not clear due to lack of study. In this work, effects from dietary fat on modulation of mouse responses to total-body-irradiation (TBI) were studied. The mice were fed after weaning at postnatal age of 4 weeks with a standard diet (MB-1), a very high-fat diet (HFD32), and a very low-fat diet (CE-2 Low Fat), containing of 4.4%, 32.0%, and 0.4% of crude fat, respectively. A mouse model for radiation-induced adaptive response (AR) was applied to this work. The priming low-dose TBI at a dose of 0.5 Gy from X-rays was given at postnatal age of 6 weeks, and the challenge high dose of TBI was given at postnatal age of 8 weeks. The mouse response to low dose of TBI was evaluated by the efficacy of the priming low dose to rescue the animals from bone marrow death induced by the challenge high dose in the 30-day survival test. The mouse response to high dose of TBI was evaluated by comparing the LD50 in the 30day survival test. In addition, dietary modulation of the residual (late) genotoxic effect from TBI was also evaluated by comparing the incidence of micronucleated erythrocytes in bone marrow using micronucleus test. Results showed that for the mice fed with the MB-1, a successful AR was demonstrated. While for the mice fed with either HFD32 or CE-2 Low Fat, no AR was observed, and all the animals died within 15 days after TBI with the challenge high dose at 7.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Modification of Mouse Response to Total-Body-Irradiation

Wang¹,

Tanaka²,

Katsube³

et al. 2015

Evolution of Ionizing Radiation Research

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“…Radiation is also a significant health risk factor, and is associated with both acute and chronic effects depending on the quality and dose of radiation. The effects of radiation on human health may be mediated, at least in part, by lifestyle-related factors, such as diet [ 8 – 10 ]. For example, the findings from epidemiological studies in nuclear plant workers suggest that lifestyle-related factors, including alcohol consumption, influence the adverse effects of radiation [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Intake of Japanese Sake Mediates Radiation-Induced Metabolic Alterations in Mouse Liver

Nakajima¹,

Varès²,

Wang³

et al. 2016

PLoS ONE

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Sake is a traditional Japanese alcoholic beverage that is gaining popularity worldwide. Although sake is reported to have beneficial health effects, it is not known whether chronic sake consumption modulates health risks due to radiation exposure or other factors. Here, the effects of chronic administration of sake on radiation-induced metabolic alterations in the livers of mice were evaluated. Sake (junmai-shu) was administered daily to female mice (C3H/He) for one month, and the mice were exposed to fractionated doses of X-rays (0.75 Gy/day) for the last four days of the sake administration period. For comparative analysis, a group of mice were administered 15% (v/v) ethanol in water instead of sake. Metabolites in the liver were analyzed by capillary electrophoresis-time-of-flight mass spectrometry one day following the last exposure to radiation. The metabolite profiles of mice chronically administered sake in combination with radiation showed marked changes in purine, pyrimidine, and glutathione (GSH) metabolism, which were only partially altered by radiation or sake administration alone. Notably, the changes in GSH metabolism were not observed in mice treated with radiation following chronic administration of 15% ethanol in water. Changes in several metabolites, including methionine and valine, were induced by radiation alone, but were not detected in the livers of mice who received chronic administration of sake. In addition, the chronic administration of sake increased the level of serum triglycerides, although radiation exposure suppressed this increase. Taken together, the present findings suggest that chronic sake consumption promotes GSH metabolism and anti-oxidative activities in the liver, and thereby may contribute to minimizing the adverse effects associated with radiation.

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“…By contrast, Yoshida et al (7) observed a life-shortening of 59 days (7.1%) in calorie-restricted mice after 3 Gy acute irradiation, but of 113 days (14.4%) in non-restricted mice. Shang et al (9) found a reduced lifespan of 393 days (37.5%) in the calorierestricted group after 3.8 Gy acute irradiation and of 331 days (37.7%) in the non-restricted group. Thus, these studies showed that the life-shortening effect of acute radiation exposure is reduced or similar in calorie-restricted mice compared to that in non-calorie-restricted mice.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, the lifespans of irradiated rats and mice were also shown to be improved by food or calorie restriction (7,8). More recently, Shang et al (9) demonstrated that calorie restriction in male B6C3F1 mice at an adult age (7 weeks old) was effective in reducing the neoplasm induction and life shortening induced by irradiation of 1-week-old infants, suggesting that the late effects of long-term radiation can be modified by calorie restriction.…”

Section: Introductionmentioning

confidence: 99%

Life-Shortening Effect of Chronic Low-Dose-Rate Irradiation in Calorie-Restricted Mice

Yamauchi¹,

Ono²,

Ayabe

et al. 2019

Radiation Research

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Calorie restriction is known to influence several physiological processes and to alleviate the late effects of radiation exposure such as neoplasm induction and life shortening. However, earlier related studies were limited to acute radiation exposure. Therefore, in this study we examined the influence of chronic low-dose-rate irradiation on lifespan. Young male B6C3F1/Jcl mice were divided randomly into two groups, which were fed either a low-calorie (65 kcal/ week) or high-calorie (95 kcal/week) diet. The latter is comparable to ad libitum feeding. The animals in the irradiated group were continuously exposed to gamma rays for 400 days at 20 mGy/day, resulting in a total dose of 8 Gy. Exposure and calorie restriction were initiated at 8 weeks of age and the diets were maintained for life. The life-shortening effects from chronic whole-body irradiation were compared between the groups. Body weights were reduced in calorierestricted mice irrespective of radiation treatment. Radiation induced a shortened median lifespan in both groups, but to a greater extent in the calorie-restricted mice. These results suggest that calorie restriction may sensitize mice to chronic low-dose-rate radiation exposure to produce a life-shortening effect rather than alleviating the effects of radiation.

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Cancer prevention by adult‐onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice

Cited by 30 publications

References 46 publications

Dietary Modification of Mouse Response to Total-Body-Irradiation

Dietary Modification of Mouse Response to Total-Body-Irradiation

Chronic Intake of Japanese Sake Mediates Radiation-Induced Metabolic Alterations in Mouse Liver

Life-Shortening Effect of Chronic Low-Dose-Rate Irradiation in Calorie-Restricted Mice

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