Cancer incidence in women with or at risk for HIV

Phelps, Ruby; Smith, Dawn K.; Heilig, Charles M.; Gardner, Lytt I.; Carpenter, Charles C. J.; Klein, Robert S.; Jamieson, Denise J.; Vlahov, David; Schuman, Paula; Holmberg, Scott D.

doi:10.1002/ijc.1528

Cited by 79 publications

(40 citation statements)

References 28 publications

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“…All 10 studies reported increased risk for lung cancer associated with HIV infection ( Figure 1); in two studies, the estimated risk did not achieve statistical significance. SIRs were generally in the range of a 2-to 3-fold increased risk; two studies reported notably higher risk estimates (29,31). A recent study of HIV-infected and at-risk women reported elevated lung cancer risk in both groups compared with population estimates (37); the unadjusted incidence rate ratio for HIV-infected compared with uninfected women was increased 2-fold, although, with only 14 cases, this estimate was imprecise (95% confidence interval [CI], 0. .…”

Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 95%

“…Although there is a clear and consistent demonstration of elevated lung cancer risk among HIV-infected persons compared with the general population (Figure 1), it cannot be fully determined whether this elevated risk is due solely to heavy smoking in the HIV-infected population. In contrast, five studies have directly accounted for individual smoking exposure among HIV-infected persons and an epidemiologicly appropriate comparison population (Table 3) (3,4,29,41,42). In these studies, the risk for lung cancer associated with HIV infection after adjusting for smoking ranged from a 1.2-to 3.6-fold increase (Figure 2).…”

Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 99%

“…In these studies, the risk for lung cancer associated with HIV infection after adjusting for smoking ranged from a 1.2-to 3.6-fold increase (Figure 2). In a study of HIVinfected and high-risk, uninfected women followed in the same cohort (29), five lung cancer cases were identified. Smoking history was considered only at baseline, and a 3.3-fold nonsignificant increased risk of lung cancer was observed with HIV infection.…”

Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 99%

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HIV Infection in the Etiology of Lung Cancer: Confounding, Causality, and Consequences

Kirk

Merlo²

2011

Proceedings of the American Thoracic Society

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Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 95%

Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 99%

Section: Epidemiologic Data On the Association Of Hiv With Lung Cancermentioning

confidence: 99%

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HIV Infection in the Etiology of Lung Cancer: Confounding, Causality, and Consequences

Kirk

Merlo²

2011

Proceedings of the American Thoracic Society

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“…This was followed by reports of a markedly higher risk of developing malignancies such as Kaposi's sarcoma (KS) [2] and [3], primary cerebral and systemically occurring non-Hodgkin lymphoma (NHL) [4], [5], [6], [7] and [8] as well as invasive cervical cancer in those harbouring this virus, although the incidence of the latter malignancy has not increased as dramatically [9] and [10].…”

Section: Introductionmentioning

confidence: 99%

Human immunodeficiency and Hodgkin lymphoma

Sissolak

Jacobs

2010

Transfusion and Apheresis Science

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Presentation of Hodgkin lymphoma (HL) is distinctive in the infected individual being more advanced, accompanied by B symptoms and the presence of extranodal disease particularly lymphadenopathy of the head and neck. Bone marrow involvement may be found in over 50% of cases. Virtually all co express gamma-herpesvirus. Phenotypically there is prominence of the mixed-cellularity and lymphocyte depleted histopathologic subtypes that define an aggressive clinical course in comparison to other variants. Prior to the induction of cART, median survival was only 1-2 years. Notably the first chemotherapy trial using ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) in 21 patients, without treating the viral infection, resulted in a 43% complete remission rate accompanied by severe haematological toxicities but did not extend median survival with this being 1.5 years matching the negative cases.Significant change accompanied concomitant anti-retroviral therapy that could be given safely even with dose intensive regimens exemplified by BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) in 12 patients or the Stanford V regimen (doxorubicin, vinblastine, mechlorethamine, etoposide, vincristine, bleomycin, prednisone) coupled with involved-field radiation for bulky disease studied in 59 patients. BEACOPP extended overall survival (OS) to 83% at 2 years. A similar trend was seen 1 when using the Stanford V regimen with an OS rate of 51% at 3 years, disease-free survival (DFS) of 68% and freedom from progression (FFP) in 60%. Additional benefits accrued from supportive care with stimulatory peptides such as G-CSF and when combined with bacterial prophylaxis results approached that found in the uninfected reference group. Current consensus holds this particular lymphoma as still among the non-AIDS defining cancers being lung, stomach, liver or anal despite these having recently gained more attention as several of these neoplasms may be occurring more commonly in the era of cART.While the relative risk of developing a non-AIDS-defining neoplasm in HIV-infected persons on the average is 2-3 times, the risk for developing HL in HIV-infected cases impressively ranges between 5 and 25 times when compared to the general population. Based on the precedent in which Kaposi sarcoma and the non-Hodgkin lymphomas distinctively alter the course of this retroviral infection in a way indistinguishable from concurrent Hodgkin lymphoma we propose that this entity be similarly regarded and the hypothesis tested in large randomised prospective study.

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“…Smoking among people with HIV may confer increased risks of medical consequences including development of bacterial pneumonia, cardiovascular disease, emphysema, lung cancer, periodontal disease, oral candidiases, oral hairy leukoplakia, oral lesions, Karposi's sarcoma, and AIDS dementia complex compared to HIV positive non-smokers (Burns et al 1996;Diaz et al 2000;Niaura et al 2000;Palacio et al 1997;Nieman et al 1993;Phelps et al 2001). Smoking is related to increased rates of depression and neurological disease among this HIV positive people, and smoking during pregnancy triples the risk of HIV transmission to the fetus (Niaura et al 2000).…”

Section: Introductionmentioning

confidence: 99%

A Test of Motivational Plus Nicotine Replacement Interventions for HIV Positive Smokers

2007

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The purpose of this study was to test two combination motivational plus pharmacological interventions for smoking cessation among HIV positive smokers. Participants were 40 adults receiving HIV care who smoked daily reporting interest in smoking reduction. Measures were administered at baseline, 1-month, and 3-month follow-ups. Participants were randomly assigned to self-guided reading plus nicotine patch (n = 18) or motivational interviewing plus nicotine patch (n = 22). Groups did not differ at 3 months on biochemically-verified abstinence. The sample reduced cigarettes per day by half a pack and the percent of smoking days by 41%, and 22% were abstinent at 3-month follow-up. Compliance with the nicotine patch was poor and declined over time, but patch use was unrelated to carbon monoxide level at 3-month follow-up. Smoking cessation interventions for people with HIV can be helpful and should include components that encourage some smoke-free days, increase self-efficacy, and attend to adherence to nicotine replacement treatment.

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Cancer incidence in women with or at risk for HIV

Abstract: The purpose of our study was to identify the types and rates of cancers seen in high-risk human immunodeficiency virus (

Cited by 79 publications

References 28 publications

HIV Infection in the Etiology of Lung Cancer: Confounding, Causality, and Consequences

HIV Infection in the Etiology of Lung Cancer: Confounding, Causality, and Consequences

Human immunodeficiency and Hodgkin lymphoma

A Test of Motivational Plus Nicotine Replacement Interventions for HIV Positive Smokers

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