Cancer Immunology

Goldman, Leon

doi:10.1001/archderm.1961.01580180064011

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1963

1968

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Cited by 10 publications

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Halo nevi

and

Helwig

1968

Cancer

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The clinicopathologic features of 108 halo nevi removed from 100 patients are presented, as well as a review of the previous reports on this subject. The term “halo nevus” is used to describe a pigmented nevus surrounded by a zone or margin of depigmented skin and having a life history that includes the centripetal extension of the depigmented halo and the spontaneous disappearance of the nevus. This process is most commonly found on the trunk of young Caucasian persons; it does not appear to be directly related to vitiligo but may be related to actinic radiation. The microscopic features consist of a nevus cell nevus, usually compound in type and infiltrated and surrounded by lymphocytes and histiocytes. The halo area has dopa‐negative clear cells at all levels of the epidermis; electron microscopy has shown these to be Langerhans' cells. Differentiation of halo nevus from malignant melanoma and inflammatory dermatoses is presented.

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