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“…3 In the ensuing decades, several case reports and studies confirmed the association between CRC and UC. 4,5 In some earlier reports, the risk of CRC was reported to be as high as 60%, 6 and many surgeons at that time advocated prophylactic colectomy as a precaution in extensive colitis greater than 10 years’ duration. Chronic mucosal inflammation forms the background on which CRC develops in UC, and CRC associated with UC constitutes 1% of all CRC.…”
Section: Introductionmentioning
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“…3 In the ensuing decades, several case reports and studies confirmed the association between CRC and UC. 4,5 In some earlier reports, the risk of CRC was reported to be as high as 60%, 6 and many surgeons at that time advocated prophylactic colectomy as a precaution in extensive colitis greater than 10 years’ duration. Chronic mucosal inflammation forms the background on which CRC develops in UC, and CRC associated with UC constitutes 1% of all CRC.…”
Section: Introductionmentioning
“…5 It has been known for long time that UC is associated with an increased risk of CRC. 6,7 The association between CRC and Crohn's disease has more recently been recognized. [8][9][10][11] Population-based, mostly European, studies have determined that the cumulative risk for colorectal cancer in patients with UC is between 5.5% and 13.5% with a relative risk for the development of CRC in patients with Crohn's disease, perhaps as high as 5.6%.…”
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