Biochemical Pharmacology volume 80, issue 12, P1771-1792 2010 DOI: 10.1016/j.bcp.2010.06.036 View full text
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Alexander Link, Francesc Balaguer, Ajay Goel

Abstract: AbstractEpigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression. In mammals, epigenetic mechanisms include changes in DNA methylation, histone modifications and non-coding RNAs. Although epigenetic changes are heritable in somatic cells, these modifications are also potentially reversible, which makes them attractive and promising avenues for tailoring cancer preventive and therapeutic strategies. Burgeoning evidence…

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