2019
DOI: 10.1136/gutjnl-2018-317645
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Abstract: ObjectiveCancer-associated fibroblasts (CAFs), a major component of cancer stroma, can confer aggressive properties to cancer cells by secreting multiple factors. Their phenotypes are stably maintained, but the mechanisms are not fully understood. We aimed to show the critical role of epigenetic changes in CAFs in maintaining their tumour-promoting capacity and to show the validity of the epigenomic approach in identifying therapeutic targets from CAFs to starve cancer cells.DesignTwelve pairs of primary gastr… Show more

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Cited by 64 publications
(43 citation statements)
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“…For instance, cancer-associated myofibroblasts (CAMs, also known as cancer-associated fibroblasts, or CAFs) from GC consistently displayed increased expression of Wnt5a, compared to adjacent tissue myofibroblasts (ATMs) . More recently, a study comparing the methylation and trimethylation (H3K23me3) patterns between CAFs and non-CAFs also identified WNT5A as a target for H3K23me3 predominantly in CAFs and corroborated that CAFs secreted more WNT5A than GC cell lines (Maeda et al, 2019). More importantly, this report showed that, in histological samples, WNT5A had higher expression in fibroblasts (which were identified by α-SMA staining), compared to cancer cells (Maeda et al, 2019).…”
Section: Wnt5a Expression In Gastric Cancersupporting
confidence: 52%
“…For instance, cancer-associated myofibroblasts (CAMs, also known as cancer-associated fibroblasts, or CAFs) from GC consistently displayed increased expression of Wnt5a, compared to adjacent tissue myofibroblasts (ATMs) . More recently, a study comparing the methylation and trimethylation (H3K23me3) patterns between CAFs and non-CAFs also identified WNT5A as a target for H3K23me3 predominantly in CAFs and corroborated that CAFs secreted more WNT5A than GC cell lines (Maeda et al, 2019). More importantly, this report showed that, in histological samples, WNT5A had higher expression in fibroblasts (which were identified by α-SMA staining), compared to cancer cells (Maeda et al, 2019).…”
Section: Wnt5a Expression In Gastric Cancersupporting
confidence: 52%
“…During tumor progression, this microenvironment develops anatomically distinct "niches", leading to enrichment of a small population of "stem-like" cells that have a distinct survival advantage over the bulk of the tumor cells. This population contributes to the aggressive biology of the disease [2][3][4] . Our previous studies show that this aggressive population has increased selfrenewal properties (contributing to tumor recurrence), increased invasiveness, and ability to evade adverse chemotherapeutic assault on the tumor and is represented by the expression of CD133 on their surface 5,6 .…”
Section: Introductionmentioning
confidence: 99%
“…Genome-wide DNA methylation and H3K27me3 analyses revealed that CAFs had diverse and distinct DNA methylation and H3K27me3 patterns. Moreover, the authors showed that loss of H3K27me3 in CAFs led to secretion of the cancer cell niche factors, and among these factors, WNT5A might promote the aggressive characteristics of GCSCs [37].…”
Section: Gcscs and The Immune Microenvironmentmentioning
confidence: 99%