Cancer Burden in Latin America and the Caribbean

Curado, María Paula; Souza, Dyego Leandro Bezerra de

doi:10.1016/j.aogh.2014.09.009

Cited by 52 publications

(18 citation statements)

References 25 publications

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“…Nonetheless, more efforts are required. The highest incidence and mortality rates found in these countries agree with previous studies [5,8,43], which showed that in Cuban and Brazilian men both OC incidence and mortality tend to increase.…”

Section: Resultssupporting

confidence: 91%

“…It is the fifth most frequent cancer among men in Brazil [6]; whereas men in Cuba present a higher mortality for this type of cancer in comparison with their peers in the United States and Canada, with a tendency to increase [7]. This reflects a clear disparity between sexes, where men bear 72% of the burden of this disease in the region, with standardized mortality ratios from OC (8.7) being surpassed only by lung cancer (11.0) [8]. However, more relevance and social intervention have been given to other types of cancer that are less prevalent and in other population groups.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between the Human Development Index and its Components with Oral Cancer in Latin America

Herrera-Serna¹,

Lara-Carrillo²,

Toral-Rizo³

et al. 2019

JEGH

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To evaluate the relationship between the Human Development Index (HDI) and its components with oral cancer (OC) in Latin America. Ecological study in 20 Latin American countries in 2010 and 2017, which evaluated the relationship between the Age-Standardized Rates (ASRs) of incidence and mortality from oral cancer and the following indicators: HDI, with its components (income, education, and health indexes); and the Gini and Theil-L indexes. Among the countries with the highest HDI, men from Brazil and Cuba had the highest incidence and mortality ASRs per 100,000 inhabitants (ASR incidence >7.5 and mortality >4.5). Among those with the lowest HDI, Haiti was the most affected country (ASR incidence >4.1 and mortality >3.0). The highest male:female ratio was in Paraguay in both years (incidence >3.5 and mortality >4.0). Mortality from oral cancer is negatively related to the global HDI in both years, with regression coefficients (95% confidence interval) being −5.78 (−11.77, 0.20) in 2010 and −5.97 (−11.38, −0.56) in 2017; and separate (independent) from the income [−4.57 (−9.92, 0.77) in 2010 and −4.84 (−9.52, −0.17) in 2017] and health indexes [−5.81 (−11.10, −0.52) and −6.52 (−11.32, −1.72) in 2017] (p < 0.05) in the countries with lower HDI. Oral cancer incidence and mortality rates vary both among and within Latin American countries according to sex, with a greater burden on men. The HDI is negatively related to mortality from oral cancer in the countries of medium and low HDI.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Relationship between the Human Development Index and its Components with Oral Cancer in Latin America

Herrera-Serna¹,

Lara-Carrillo²,

Toral-Rizo³

et al. 2019

JEGH

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“…Across the Caribbean, few epidemiologic studies are available on cervical cancer incidence and survival [14]. Over the last decade, the burden of cervical cancer has been established and several National Cancer Plans have been presented.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival of cervical cancer in the French West-Indies: data from the Martinique Cancer Registry (2002–2011)

Melan

Janky

Macni

et al. 2017

Global Health Action

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Background: The Caribbean ranks seventh among world regions most affected by cervical cancer. Social health inequalities, such as differences in access to screening services, engender disparities in incidence and mortality between low- and middle-income countries and industrialized countries. The French National Cancer Plan 2014–2019 focuses on reducing inequalities in cervical cancer.Objective: The aim of this study was to describe the geographical distribution and overall survival of cervical cancer, based on data from a population-based cancer registry in Martinique (French West-Indies).Methods: We included all cases of cervical cancer diagnosed between 2002 and 2011. The geographical distribution was described by zone of residence and by aggregated units for statistical information (IRIS). Based on the results of the model, standardized incidence rates (SIRs) were calculated using a Gamma Poisson model. Survival rates were calculated using the Kaplan–Meier method. Cox proportional hazards models were used to investigate the risk factors for cervical cancer mortality.Results: A total of 1253 cases were analyzed (947 in situ tumors and 306 invasive cancers). 1230 cases with geolocalization were used to map the distribution of the incidence of in situ and invasive cervical cancers. Five IRIS were significantly over-incident. The 5-year overall survival rate was 55%, with a median survival of 6.5 years [95% CI: 4.9–10.1]. Multivariate analysis confirmed age at diagnosis (HR = 2.15 [1.50–3.09]; p < 0.0001), FIGO stage (HR = 3.53 [2.50–4.99]; p < 0.0001) and zone of residence (HR = 1.51 [1.06–2.13]; p = 0.02) as risk factors.Conclusions: Prognostic factors suggest that cervical cancer needs to be diagnosed at an early stage. Our results could allow cervical cancer screening programs to clearly identify geographical areas that would benefit from targeted interventions with a view to reducing incidence and mortality of cervical cancer in the Caribbean.

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“…Decades of Papanicolaou-based screening to detect pre-cancerous cervical lesions in a few countries of the region have not had a major impact in reducing CC incidence and mortality rates, which are still high across LA. Moreover, estimates indicate an overall 72% increase in the incidence of CC and a 78% rise in mortality by this disease between 2012 and 2030 (6). Each year, about 1.1 million new CC cases and 600,000 deaths are recognized in LA and the Caribbean.…”

Section: Epidemiology Of Hpv-related Neoplasias In Lamentioning

confidence: 99%

The contribution of Latin American research to HPV epidemiology and natural history knowledge

Sichero

Picconi

Villa

2020

Braz J Med Biol Res

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Our aim was to review the major contributions of studies conducted in different Latin American (LA) countries to the field of human papillomavirus (HPV) epidemiology, natural history, risk of disease, and prevention strategies, mainly in the uterine cervix. Although cytological screening is established in several countries in LA, incidence and mortality rates from cervical cancer (CC) are still extremely high. Finally, data from large cohort studies conducted in LA countries provided seminal data to propose primary and secondary prevention modalities: the HPV vaccine has been introduced in the national immunization programs of several LA countries and multiple screening experiences using HPV testing are under evaluation in the region.

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Cancer Burden in Latin America and the Caribbean

Cited by 52 publications

References 25 publications

Relationship between the Human Development Index and its Components with Oral Cancer in Latin America

Relationship between the Human Development Index and its Components with Oral Cancer in Latin America

Epidemiology and survival of cervical cancer in the French West-Indies: data from the Martinique Cancer Registry (2002–2011)

The contribution of Latin American research to HPV epidemiology and natural history knowledge

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