2017
DOI: 10.1016/j.ccell.2017.10.005
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Abstract: Summary Tumor associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited antitumor effects. Here, we have identified the mechanism that limited the effect of CSF1R targeted therapy. We demonstrated that carcinoma associated fibroblasts (CAF) are major sources of chemokines that recruit granulocytes to tumors. CSF1 produced by tumor cells caused HDAC2-mediated down-regulation of granulocyte-specific ch… Show more

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Cited by 454 publications
(350 citation statements)
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“…Numerous populations of immune cells have been reported to have suppressive functions in the TIME (for example, neutrophils 49 and T reg cells 50 ); however, TAMs are the most extensively studied and well characterized. Recent data in mice suggest that the immunological origin of TAMs (yolk sac or monocyte derived) can substantially affect their overall suppressiveness.…”
Section: Analyzing Progressive Development Of the Time At Primary Andmentioning
confidence: 99%
“…Numerous populations of immune cells have been reported to have suppressive functions in the TIME (for example, neutrophils 49 and T reg cells 50 ); however, TAMs are the most extensively studied and well characterized. Recent data in mice suggest that the immunological origin of TAMs (yolk sac or monocyte derived) can substantially affect their overall suppressiveness.…”
Section: Analyzing Progressive Development Of the Time At Primary Andmentioning
confidence: 99%
“…Multiple studies have shown an anti‐tumour effect of inhibiting the colony‐stimulating factor 1 receptor (CSF1R). Vinit et al found that CSF1R inhibition decreased TAMs, which was correlated with the recruitment and accumulation of polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSCs) in tumours, and an increase in the secretion of CXCL‐1 by CAFs . This demonstrated a potential correlation between CAFs and MDSCs.…”
Section: Crosstalk Between Cancer‐associated Fibroblasts and Immune Cmentioning
confidence: 98%
“…Combination therapies of substances, which did not show sufficient efficacy as single agents, are explored for synergistic efficacy. Combining a CSF1R inhibitor and a CXCR2 antagonist results in improved efficacy, however, when a checkpoint inhibitor is added, dramatic therapy effects have been reported 117. Mace et al reported that PD-L1 immunotherapy can be boosted in a CD8 +  T-cell-dependent manner by blockade of IL-6, which is produced by pancreatic stellate cells 120…”
Section: Introductionmentioning
confidence: 99%