2019
DOI: 10.1124/jpet.119.256818
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Abstract: The dopamine D 2 receptor (D 2 R) family is upregulated in many cancers and tied to stemness. Reduced cancer risk has been correlated with disorders such as schizophrenia and Parkinson's disease, in which dopaminergic drugs are used. D 2 R antagonists are reported to have anticancer efficacy in cell culture and animal models where they have reduced tumor growth, induced autophagy, affected lipid metabolism, and caused apoptosis, among other effects. This has led to several hypotheses, the most prevalent being … Show more

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Cited by 69 publications
(46 citation statements)
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“…1 DRD2 Overexpression in Human Cancer. The indicated publications for each tumor type were identified through a PubMed search as of July 2020, as well as recent reviews of DRD2 in oncology [19] , [20] . …”
Section: Onc201 Mechanism Of Actionmentioning
confidence: 99%
“…1 DRD2 Overexpression in Human Cancer. The indicated publications for each tumor type were identified through a PubMed search as of July 2020, as well as recent reviews of DRD2 in oncology [19] , [20] . …”
Section: Onc201 Mechanism Of Actionmentioning
confidence: 99%
“…From 2003 onwards, several screening studies were conducted to evaluate D 2 -receptor antagonists as potential agents for cancer treatment, given that D 2 -receptors are present in various cancer cell lines. D 2 -receptor antagonists showed biological effects against cancer in vitro and in vivo [33]. Moreover, D 2 -receptor agonists increased phosphorylation at threonine 308 of Akt in neurons [34], and Akt phosphorylation is known to plays a vital role in cell proliferation; this suggests that D 2 - receptors are associated with tumourigenesis.…”
Section: Mechanism Of Action Of Penfluridol On Cancermentioning
confidence: 99%
“…Although our understanding of the biology of dopamine receptor signaling in cancer progression is still rudimentary and sometimes controversial, mounting experimental and clinical evidence has indicated that the dysregulation of dopamine receptor signaling is associated with the progression of human cancers, including PCa (35,(57)(58)(59)(60). Some epidemiologic studies further suggested a correlation between psychotic disorders in which dopaminergic drugs are applied and the risk of cancer, of particular note, a reduced risk of PCa (61,62).…”
Section: Discussionmentioning
confidence: 99%