Cancer: a new role for non-canonical Hippo signaling

Cooper, Jonathan M.; Giancotti, Filippo G.

doi:10.1038/cr.2017.27

Cited by 4 publications

(3 citation statements)

References 12 publications

(17 reference statements)

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“…Taken together, these studies present convincing evidence that LATS1/2 may be a novel target for anticancer treatment in breast cancer. 52 However, less is known about the role of MST in breast cancer metastasis. Existing studies suggest that high MST1 expression in MCF-7 breast cancer cells can inhibit cell proliferation and promote cell apoptosis.…”

Section: Role Of Hippo Pathway Components In Breast Cancer Metastasismentioning

confidence: 99%

The role of Hippo signal pathway in breast cancer metastasis

Wei¹,

Wang²,

Li³

2018

OTT

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The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.

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Section: Role Of Hippo Pathway Components In Breast Cancer Metastasismentioning

confidence: 99%

The role of Hippo signal pathway in breast cancer metastasis

Wei¹,

Wang²,

Li³

2018

OTT

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“…Recently, the available data suggest that Hippo/YAP pathway has been considered as a brake on cell division that can prevent organs from growing larger, once they have reached the appropriate size [ 34 , 35 ]. Giancotti et al reported that LATS1/2 could facilitate ERα ubiquitylation by the E3 ligase CRL4 DCAF1 [ 36 ]. More recently, Adrian et al and Guan et al, respectively, identified that there was a direct interaction between Hippo and ERα signaling [ 37 , 38 ], in which Hippo signaling maintained ER expression and regulated ER+ BC growth.…”

Section: Discussionmentioning

confidence: 99%

ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway

Lin

Xiong

et al. 2021

Cell Death Dis

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Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the urgent need to seek novel therapeutic targets. Arylsulfatase D (ARSD), localized at Xp22.3, is a female-biased gene due to its escaping from X chromosome inactivation (XCI). Unfortunately, no systematic investigation of ARSD on BC has been reported. In this study, we observed that ARSD expression was positively related to ERα status either in BC cells or tissue specimens, which were associated with good prognosis. Furthermore, we found a set of hormone-responsive lineage-specific transcription factors, FOXA1, GATA3, ERα, directly drove high expression of ARSD through chromatin looping in luminal subtype BC cells. Opposingly, ARSD still subjected to XCI in TNBC cells mediated by Xist, CpG islands methylation, and inhibitory histone modification. Unexpectedly, we also found that ectopic ARSD overexpression could inhibit proliferation and migration of TNBC cells by activating Hippo/YAP pathway, indicating that ARSD may be a molecule brake on ERα signaling pathway, which restricted ERα to be an uncontrolled active status. Combined with other peoples’ researches that Hippo signaling maintained ER expression and ER + BC growth, we believed that there should exist a regulative feedback loop formation among ERα, ARSD, and Hippo/YAP pathway. Collectively, our findings will help filling the knowledge gap about the influence of ARSD on BC and providing evidence that ARSD may serve as a potential marker to predict prognosis and as a therapeutic target.

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“…It would be possible that the kinase cassette of the Hippo pathway is conserved, and even that Yorkie also acts downstream of the pathway in planarians. However, it could also be that some of the defects observed in planarians depend on the activity of the kinases but not of Yorkie, since the Hippo kinase cassette has been demonstrated to exert several Yorkie independent function [23].…”

Section: Alternative Explanationsmentioning

confidence: 99%

Functional characterization of <em>salvador</em> and <em>warts</em> in planarians

Sousa

Pascual-Carreras

Saló

et al. 2019

Matters

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In the last years, the Hippo signaling has emerged as an essential pathway to control tissue and organ homeostasis, and its deregulation leads to tumoral transformation in all animals studied. However, the underlying cellular and molecular mechanism of this transformation are still not clear. The core of the Hippo pathway includes a kinase cassette composed by the kinases Hippo, Salvador, Mats, and Warts that in turn phosphorylates the nuclear effector of the pathway, Yorkie, targeting it to proteasomal degradation. Recently, the functional study of hippo, in planarians, flatworms that continuously change their size and renew their tissues according to nutrients, allowed demonstrating that the underlying mechanism of cellular transformation was not an increase in cell proliferation but inducing cell cycle arrest and promoting cell dedifferentiation. However, the functional study of yorkie did not allow to relate it with the Hippo function.Here, we show that inhibition of salvador and warts phenocopies the defects observed in hippo RNAi planarians. Since Warts is responsible for phosphorylating yorkie, this data suggests that not only the kinase cassette of the Hippo pathway is functionally conserved but also the nuclear effector.

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Cancer: a new role for non-canonical Hippo signaling

Cited by 4 publications

References 12 publications

The role of Hippo signal pathway in breast cancer metastasis

The role of Hippo signal pathway in breast cancer metastasis

ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway

Functional characterization of <em>salvador</em> and <em>warts</em> in planarians

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