Can we use endocan level to determine severity of pancreatitis?

Baykan, Ahmed Ramiz; Baydar, İdris; Şebin, Engin; Özdemir, Yılmaz; Cerrah, Serkan; Albayrak, Bülent; Şentürk, Mehmet Fatih

doi:10.51821/84.2.321

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Albayrak et al, endocan levels, secreted by endothelial cells in response to inflammatory cytokines, were shown to be useful in determining the prevalence of ulcerative colitis characterized by mucosal inflammation and could be beneficial in treatment planning. [23,24] Elevated levels of endocan, similar to SAL-β, were found in both patients with AP and severe ulcerative colitis, aligned with the design of our study. Ultimately, biomarkers identified as elevated in severe pancreatitis can be used for prognosis monitoring and assist clinicians.…”

Section: Discussionsupporting

confidence: 86%

Relationship between salusin beta levels and the severity of acute pancreatitis in patients

Albayrak,

Guneyin,

Celik

2024

Medicine

View full text Add to dashboard Cite

Background: This study aimed to evaluate the significance of serum salusin beta (SAL-β) levels in predicting the severity of acute pancreatitis (AP) in patients diagnosed with this condition and to assess its relationship with disease and prognosis. Methods: Sixty-four patients between 18 and 100 years of age diagnosed with AP, were included in the study. Patients were categorized into 3 groups based on the Revised Atlanta Classification: mild, moderate, and severe AP. Eighteen healthy adults were included as the control group. Sex, age, height, weight, presence of additional diseases, laboratory results, imaging findings, levels of white blood cells, neutrophil-lymphocyte ratio, mean platelet volume, amylase, lipase, sensitive C-reactive protein, sedimentation, and serum SAL-β were measured and recorded. SAL-β levels were reevaluated on the third day of hospitalization. Results: The average age of the patients included in the study was 62.66 ± 17.67. Gallstones were present in 64.1% of the patients. The difference in the SAL-β averages on the 1st and 3rd days was statistically significant (P < .05). On the first day, the SAL-β averages of those with severe Atlanta scores were higher than those with mild and moderate Atlanta severity. Similarly, on the third day, the SAL-β averages of those with severe Atlanta scores were higher than those with mild and moderate Atlanta severity. According to receiver operating characteristic analysis using the Youden index, the cutoff value for SAL-β for severe pancreatitis was 178.8 pg/mL on the 1st day and 207.5 pg/mL on the 3rd day. Conclusion: SAL-β can be used to detect and monitor severe pancreatitis. Further extensive clinical studies with larger case series are needed.

show abstract

Section: Discussionsupporting

confidence: 86%

Relationship between salusin beta levels and the severity of acute pancreatitis in patients

Albayrak,

Guneyin,

Celik

2024

Medicine

View full text Add to dashboard Cite

show abstract

“…In important diseases such as acute pancreatitis with similar in ammation, studies have shown that the level of endocan increases as the severity of the disease increases [13]. In particular, the study of Çakır et al [14] in infants with necrotizing enterocolitis showed that the endocan increased signi cantly in showing the severity of the disease, opening a new window. The most important nding in the study of Sakuraba et al [15] in 133 patients with ulcerative colitis was that the extent of the disease may affect the correlation between fecal biomarker values.…”

Section: Discussionmentioning

confidence: 99%

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

Albayrak

Şebin

2022

Preprint

View full text Add to dashboard Cite

Background and study aim Ulcerative colitis (UC) is an inflammatory bowel disease characterized by mucosal inflammation that starts from the rectum (distal) and extends proximally, involving the entire colon (pancolitis). In this study, we aimed to evaluate the usability of endocan level in determining the extent and severity of disease in patients with ulcerative colitis and to determine whether it can be a candidate marker for noninvasive evaluation and monitoring since there is not enough data in the literature. Materials and Methods Sixty-five people were included in the study, including thirty-five with ulcerative colitis and thirty in the control group. patients with newly diagnosed ulcerative colitis clinically, endoscopically, and histopathologically, without any treatment, and with normal liver and kidney tests were included in the study. Endoscopic scoring of all patients was performed according to the mayo endoscopic scoring (MES) system. Blood samples for CRP (C-reactive protein) and endocan were taken from the patients simultaneously. Results There was a significant statistical difference between all patients with ulcerative colitis and the control group in both endocan level and CRP level (p < 0.001). There was a statistically significant difference between endocan levels and CRP levels between the left-distal group and pancolitis (diffuse colitis) patients, but there was no statistical difference between age and MES. Conclusion Serum endocan level can be a useful test in determining the extent and severity of ulcerative colitis, making hospitalization decisions, and planning treatment. Stool markers may not always be available due to patient compliance.

show abstract

“…As the extent and severity of ulcerative colitis increase, inflammatory markers in serum and stool increase. In important diseases such as acute pancreatitis with similar inflammation, studies have shown that the level of endocan increases as the severity of the disease increases [ 14 ]. In particular, the study of Çakır et al [ 15 ] in infants with necrotizing enterocolitis showed that the endocan increased significantly in showing the severity of the disease, opening a new window.…”

Section: Discussionmentioning

confidence: 99%

A novel inflammatory marker for extensive ulcerative colitis; Endocan

Albayrak

Şebin

2023

BMC Gastroenterol

View full text Add to dashboard Cite

Background & aims Ulcerative colitis (UC) is an inflammatory bowel disease characterized by mucosal inflammation. Endocan, a proteoglycan secreted by endothelial cells in response to inflammatory cytokines, has been reported to be overexpressed in inflammatory conditions. In this study, we aimed to evaluate the utility of endocan level in determining the extent and severity of disease in patients with ulcerative colitis and to determine whether it can be a candidate marker for noninvasive evaluation and monitoring since there is not enough data in the literature. Materials and methods Sixty-five people were included in the study, including thirty-five with ulcerative colitis and thirty in the control group. Patients with first diagnosed ulcerative colitis clinically, endoscopically, and histopathologically, without any treatment, and with normal liver and kidney tests were included in the study. Endoscopic scoring of all patients was performed according to the Mayo endoscopic scoring (MES) system. Blood samples for CRP (C-reactive protein) and endocan were taken from the patients simultaneously. Results There was a significant statistical difference between all patients with ulcerative colitis and the control group in both endocan level and CRP level (p < 0.001). There was a statistically significant difference between endocan levels and CRP levels between the left-distal group and pancolitis (diffuse colitis) patients, but there was no statistical difference between age and MES. Conclusion Serum endocan level can be useful in determining the extent of ulcerative colitis and planning treatment.

show abstract

Can we use endocan level to determine severity of pancreatitis?

Cited by 4 publications

References 37 publications

Relationship between salusin beta levels and the severity of acute pancreatitis in patients

Relationship between salusin beta levels and the severity of acute pancreatitis in patients

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

A novel inflammatory marker for extensive ulcerative colitis; Endocan

Contact Info

Product

Resources

About