Can We Prevent Obesity-Related Metabolic Diseases by Dietary Modulation of the Gut Microbiota?

Brahe, Lena K.; Astrup, Arne; Larsen, Lesli H.

doi:10.3945/an.115.010587

Cited by 112 publications

(74 citation statements)

References 125 publications

(190 reference statements)

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“…Obesity is a growing health concern with approximately 20% of the youth (aged 2–19) in the United States classified as either overweight or obese (1). This number increases to approximately 35% in adults (aged 20 or older) and these statistics have seen little change since 2003 (1).…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, the body mass index (BMI) has been used to classify individuals as non-obese or obese (2). Recently, there has been increased interest in the role of the microbiome in modulating obesity (3, 4). If the microbiome does affect obesity status, then manipulating the microbiome could have a significant role in the future treatment of obesity and in helping to stem the current epidemic.…”

Section: Introductionmentioning

confidence: 99%

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Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

Sze

Schloss

2016

Preprint

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1Two recent studies have re-analyzed published data and found that when datasets are 2 analyzed independently there was limited support for the widely accepted hypothesis that 3 changes in the microbiome are associated with obesity. This hypothesis was reconsidered 4 by increasing the number of datasets and pooling the results across the individual datasets. 5The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 6 guidelines were applied to identify 10 studies for an updated and more synthetic analysis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

Sze

Schloss

2016

Preprint

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“…Obesity has become more prevalence nowadays due to the consumption of high lipid or high-energy diet1. Visceral fat obesity is often associated with increased risk for diseases such as atherosclerosis, dyslipidemia, hypertension, cerebrovascular thrombosis, diabetes and ischemic heart disease234.…”

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confidence: 99%

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

Fang

Zhong

et al. 2016

Sci Rep

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Obesity is often associated with increased risk of cardiovascular diseases. Previous studies suggest that epidermal growth factor receptor (EGFR) antagonism may be effective for the treatment of angiotensin II-induced cardiac hypertrophy and diabetic cardiomyopathy. This study was performed to demonstrate if EGFR plays a role in the pathogenesis of hyperlipidemia/obesity-related cardiac injuries. The in vivo studies using both wild type (WT) and apolipoprotein E (ApoE) knockout mice fed with high fat diet (HFD) showed the beneficial effects of small-molecule EGFR inhibitors, AG1478 and 542, against obesity-induced myocardial injury. Administration of AG1478 and 542 significantly reduced myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. In vitro, EGFR signaling was blocked by either siRNA silencing or small-molecule EGFR inhibitors in palmitic acid (PA)-stimulated cardiomyocytes. EGFR inhibition attenuated PA-induced inflammatory response and apoptosis in H9C2 cells. Furthermore, we found that PA-induced EGFR activation was mediated by the upstream TLR4 and c-Src. This study has confirmed the detrimental effect of EGFR activation in the pathogenesis of obesity-induced cardiac inflammatory injuries in experimental mice, and has demonstrated the TLR4/c-Src-mediated mechanisms for PA-induced EGFR activation. Our data suggest that EGFR may be a therapeutic target for obesity-related cardiovascular diseases.

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“…Estudios en intervenciones con personas voluntarias obesas sometidas a un régimen de dieta hipocalórica durante un año, se observó cambios de composición en su microbiota con una mayor proporción de microorganismos Gram negativos y menor proporción de Gram positivos, y tiene como resultado un cambio en la relación de microorganismos Firmicutes/Bacteroides, generando una disbiosis intestinal, que consiste en la alteración de los distintos grupos de microorganismos que conforman la microbiota intestinal, y esto tiene una relación directa con los cambios de peso corporal del individuo. (Angelakis et al, 2012;Brahe, Astrup & Larsen, 2016). Este cambio de composición de la microbiota genera un aumento plasmático de lipopolisacáridos (LPS) que favorecen los procesos inflamatorios y como consecuencia una mayor resistencia a la insulina que promueve el desarrollo de diabetes, además de favorecer el aumento de adipocitos, dislipidemia y un desequilibrio en el peso corporal en comparación con individuos de una mayor diversidad microbiológica.…”

Section: Ensayounclassified

“…Se ha observado que la microbiota del individuo obeso presenta una menor biodiversidad microbiana en comparación con individuos normales (no obesos). En este sentido, se ha observado que la influencia que tiene la microbiota intestinal en el hospedero está relacionada con las funciones de tipo metabólico, tróficas, secreción de hormonas intestinales y reguladoras del sistema inmunitario, además de tener implicación en la regulación de los depósitos de grasa corporal en tejido adiposo (Angelakis, et al, 2012;Brahe, 2016).…”

Section: Ensayounclassified

Efecto De La Dieta Sobre La Modulación De La Microbiota en El Desarrollo De La Obesidad

Diéguez

Galván²,

Rodriguez³

et al. 2018

RESPYN

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RESUMENHoy en día, la microbiota gastrointestinal se ha transformado en un tema de investigación dinámica para dilucidar su relación con la dieta y la salud metabólica del huésped. En los últimos años se ha reconocido que la microbiota intestinal presenta una interacción estrecha en la regulación de la homeostasis inmune humana y el metabolismo, esto con lleva a nuevas oportunidades para la prevención de la obesidad y las enfermedades metabólicas asociadas como la diabetes tipo 2, para generar estrategias en el tratamiento de enfermedades metabólicos y sobre todo en esclarecer la prevalencia de la obesidad. En recientes investigaciones se ha establecido elementos que permiten establecer a la microbiota intestinal como un mediador sobre el impacto de la dieta, el estado metabólico y el peso corporal del huésped. Los mecanismos que permite una relación de la microbiota del intestino con la obesidad son generados mediante la combinación de modelos con animales de experimentación y ensayos clínicos. El reto fundamental del tema es la capacidad en establecer la causalidad de la relación entre la nutrición, la microbiota y la salud del huésped, así como los factores que inciden sobre los cambios en el peso corporal del individuo. Palabras Clave: microbiota, tratamiento dietético, obesidad. ABSTRACTToday, the gastrointestinal microbiota has been transformed into a dynamic research topic to elucidate its relationship with diet and metabolic health of the host. In recent years it has been recognized that the intestinal microbiota presents a close interaction in the regulation of human immune homeostasis and metabolism, leading to new opportunities for the prevention of obesity and associated metabolic diseases such as type 2 diabetes, to generate strategies in the treatment of metabolic diseases and especially in clarifying the prevalence of obesity. Recent research has established elements that allow establishing the intestinal microbiota as a mediator on the impact of diet, metabolic status and body weight of the host. The mechanisms allowing a relationship of the intestinal microbiota with obesity are generated by combining models with experimental animals and clinical trials. The fundamental challenge of the subject is the ability to establish the causality of the relationship between nutrition, microbiota and the health of the host, as well as the factors that influence the changes in the individual's body weight.

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Can We Prevent Obesity-Related Metabolic Diseases by Dietary Modulation of the Gut Microbiota?

Cited by 112 publications

References 125 publications

Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice

Efecto De La Dieta Sobre La Modulación De La Microbiota en El Desarrollo De La Obesidad

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