2018
DOI: 10.18632/aging.101403
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Abstract: Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular mortality. Four hundred twenty-four cardiac-surgery patients (264 men and 160 women) were enrolled. At admission, all patients were tested for renal function and inflammatory status. Patients were… Show more

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Cited by 6 publications
(4 citation statements)
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References 25 publications
(26 reference statements)
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“…Recently, some authors have highlighted how the accumulation of TMAO is not only indicative of an increased CV risk but it also represents a potential early biomarker of renal dysfunction. In fact, a remarkable study has shown how in a cohort of non-CKD subjects, the highest levels of TMAO were associated with higher levels of cystatin C, highlighting how the TMAO increase may precede a slatentized kidney disease 40 , 41 . This data is confirmed by animal studies in which the TMAO increase and the chronic high dietary intake of choline are interconnected with the progression of renal tubule-interstitial fibrosis and with the development of renal dysfunction 30 , 33 , 42 .…”
Section: Discussionmentioning
confidence: 99%
“…Recently, some authors have highlighted how the accumulation of TMAO is not only indicative of an increased CV risk but it also represents a potential early biomarker of renal dysfunction. In fact, a remarkable study has shown how in a cohort of non-CKD subjects, the highest levels of TMAO were associated with higher levels of cystatin C, highlighting how the TMAO increase may precede a slatentized kidney disease 40 , 41 . This data is confirmed by animal studies in which the TMAO increase and the chronic high dietary intake of choline are interconnected with the progression of renal tubule-interstitial fibrosis and with the development of renal dysfunction 30 , 33 , 42 .…”
Section: Discussionmentioning
confidence: 99%
“…This condition could also favour a hypercoagulable state also through an increased production of inflammatory cytokines [ 2 ]. Several prothrombotic biomarkers, such as D-dimer, von Willebrand factor, and beta-thromboglobulin are present in higher concentrations in patients affected by atrial fibrillation (AF) [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cytostatin C is a nonglycosylated basic protein of the family of cysteine protease inhibitors and is used as a biomarker of renal function and recently has also been evaluated as a potential predictor of the onset or worsening of cardiovascular disease. Many studies evidenced how the easiness and speed of measurement makes cytostatin C a potentially valuable biomarker for early diagnosis of renal failure, and a formidable predictor of long‐term outcome after cardiac surgery 7 . It is interesting that a major clinical trial such as the ORIGIN trial did not consider this biomarker 8 .…”
mentioning
confidence: 99%
“…Many studies evidenced how the easiness and speed of measurement makes cytostatin C a potentially valuable biomarker for early diagnosis of renal failure, and a formidable predictor of long-term outcome after cardiac surgery. 7 It is interesting that a major clinical trial such as the ORIGIN trial did not consider this biomarker. 8 Instead, the trial found that the NT-proBNP, angiopoietin 2, and glutathione S transferase α were associated to the survival rate at follow-up.…”
mentioning
confidence: 99%