Can Serum Cystatin C predict long-term survival in cardiac surgery patients?

Rovella, Valentina; Marrone, Giulia; Dessì, Mariarita; Ferrannini, Michele; Toschi, Nicola; Pellegrino, Antonio; Casasco, Maurizio; Daniele, Nicola Di; Noce, Annalisa

doi:10.18632/aging.101403

Cited by 6 publications

(4 citation statements)

References 25 publications

(26 reference statements)

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“…Recently, some authors have highlighted how the accumulation of TMAO is not only indicative of an increased CV risk but it also represents a potential early biomarker of renal dysfunction. In fact, a remarkable study has shown how in a cohort of non-CKD subjects, the highest levels of TMAO were associated with higher levels of cystatin C, highlighting how the TMAO increase may precede a slatentized kidney disease 40 , 41 . This data is confirmed by animal studies in which the TMAO increase and the chronic high dietary intake of choline are interconnected with the progression of renal tubule-interstitial fibrosis and with the development of renal dysfunction 30 , 33 , 42 .…”

Section: Discussionmentioning

confidence: 99%

Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients’ breath

Romani

Marrone²,

Celotto³

et al. 2022

Sci Rep

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Several studies highlighted a correlation between exhaled air volatile organic compounds (VOCs) and some pathological conditions, such as chronic kidney disease (CKD), chronic liver disease, etc. In fact, in literature has been reported that CKD is characterized by an increased concentration of ammonia, trimethylamine (TMA) and isoprene compared to healthy subjects. Currently, there is not a validate and standardized method to detect VOCs. For this purpose, we examined the utility of selected ion flow tube-mass spectrometry (SIFT-MS) to measure VOCs in CKD patients and we evaluated the possible correlation between VOCs and the presence of CKD and its stage. We enrolled 68 CKD patients under conservative therapy and 54 healthy subjects. The analysis of the VOCs of the exhaled air of the enrolled subjects was performed by SIFT-MS. Among all the VOCs analyzed, the most relevant results by ROC curves were observed for TMA, acetone, ammonia and dimethyl sulfide. We found that a breath TMA concentration superior to 26 ppbv characterizes a 6.11 times greater risk of CKD, compared to subjects with lower levels. Moreover, we detected an increased concentration of acetone and ammonia in CKD patients compared to healthy subjects. We highlight the potential utility of SIFT-MS in CKD clinical management.Clinical trial registry: R.S. 15.19 of 6 February 2019.

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Section: Discussionmentioning

confidence: 99%

Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients’ breath

Romani

Marrone²,

Celotto³

et al. 2022

Sci Rep

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“…This condition could also favour a hypercoagulable state also through an increased production of inflammatory cytokines [ 2 ]. Several prothrombotic biomarkers, such as D-dimer, von Willebrand factor, and beta-thromboglobulin are present in higher concentrations in patients affected by atrial fibrillation (AF) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Female Sex as a Thromboembolic Risk Factor in the Era of Nonvitamin K Antagonist Oral Anticoagulants

Gallù

Marrone

Legramante³

et al. 2020

Cardiovascular Therapeutics

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Sex-specific differences have been definitively demonstrated in cardiovascular (CV) diseases. These differences can also impact on the effects of CV therapies. Female sex is recognized as an independent predictor of thromboembolic risk, particularly in older patients. Most of strokes are due to atrial fibrillation (AF). Women affected by AF have higher stroke risk compared to men. The introduction of novel oral anticoagulants (NOACs) for long-term anticoagulation completely changed the anticoagulant therapeutic approach and follow-up of patients affected by nonvalvular atrial fibrillation (NVAF). CHA2DS2-VASc stroke risk scoring in use in the current international guidelines attributes 1 point to “female sex”. Besides, no anticoagulation is indicated for AF female patients without other risk factors. Interestingly, NOACs seem to normalize the differences between males and females both in terms of safety and efficacy, whereas residual higher stroke risk and systemic embolism persist in AF women treated with vitamin K antagonist anticoagulants VKA with optimal time in therapeutic range. Based on the CHA2DS2-VASc score, NOACs represent the preferred choice in NVAF patients. Moreover, complete evaluation of apparently lower risk factor along with concomitant clinical conditions in AF patients appears mandatory, particularly for female patients, in order to achieve the most appropriate anticoagulant treatment, either in male or in female patients. The present review was performed to review sex differences in AF-related thromboembolic risk reported in the literature and possibly highlight current knowledge gaps in prevention and management that need further research.

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“…Cytostatin C is a nonglycosylated basic protein of the family of cysteine protease inhibitors and is used as a biomarker of renal function and recently has also been evaluated as a potential predictor of the onset or worsening of cardiovascular disease. Many studies evidenced how the easiness and speed of measurement makes cytostatin C a potentially valuable biomarker for early diagnosis of renal failure, and a formidable predictor of long‐term outcome after cardiac surgery 7 . It is interesting that a major clinical trial such as the ORIGIN trial did not consider this biomarker 8 .…”

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confidence: 99%

“…Many studies evidenced how the easiness and speed of measurement makes cytostatin C a potentially valuable biomarker for early diagnosis of renal failure, and a formidable predictor of long-term outcome after cardiac surgery. 7 It is interesting that a major clinical trial such as the ORIGIN trial did not consider this biomarker. 8 Instead, the trial found that the NT-proBNP, angiopoietin 2, and glutathione S transferase α were associated to the survival rate at follow-up.…”

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confidence: 99%

Mirror mirror on the wall, who is going to be readmitted after all?

Dokollari

Torregrossa

2021

Journal of Cardiac Surgery

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In the jungle of biomarkers that predicts long‐term outcome, there are many discrepancies and there is more evidence from single‐center retrospective studies rather than clinical trials. While some of these biomarkers such as high sensitivity troponin levels, creatine kinase (CK), and CK‐MB have demonstrated a good pattern for patients’ follow‐up, other biomarkers are still struggling to get validated and internationally renown due to the small number of patients included in the studies and their retrospective nature. In this context, Brown and colleagues must be congratulated as they have marked the pathway for future clinical trials.

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Can Serum Cystatin C predict long-term survival in cardiac surgery patients?

Cited by 6 publications

References 25 publications

Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients’ breath

Utility of SIFT-MS to evaluate volatile organic compounds in nephropathic patients’ breath

Female Sex as a Thromboembolic Risk Factor in the Era of Nonvitamin K Antagonist Oral Anticoagulants

Mirror mirror on the wall, who is going to be readmitted after all?

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