Can Regenerative Medicine and Nanotechnology Combine to Heal wounds? the Search for the Ideal Wound Dressing

Abstract

Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing. Antimicrobial activity, exogenous cell therapy, growth factor delivery, biodegradable and biocompatible matrix construction, all play a role in hi-tech dressing design. In the present review, we discuss how the principles of regenerative medicine and nanotechnology can be combined in innovative wound dressings.

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

“…By contrast, rather than serving merely as coverage, interactive dressings not only provide an ideally controlled environment (in terms of pH and temperature) to prevent wound dehydration but also interact with wound bed components (e.g., through absorb extrudes, target ‐based sterilization , and an improvement in tissue regeneration) to further promote ulcer healing. During the mid‐1990s, polymer matrices used for interactive dressings were developed into various types, including hydrocolloids, hydrogels, alginates, polyurethane, and other polymer‐based materials (Figure ) (Saco, Howe, Nathoo, & Cherpelis, ; Zarrintaj et al, ).…”

Electrospun electroactive nanofibers of gelatin‐oligoaniline/Poly (vinyl alcohol) templates for architecting of cardiac tissue with on‐demand drug release

“…Among different methods, nonwoven nanofiber mats can be fabricated by electrospinning technique as a simple and useful skill in which fibers diameter can be altered from microns to nanometers . Various natural and synthetic polymers such as chitosan, agarose, starch, Poly(lactic acid) PLA, polycaprolactone (PCL) have been used to fabricate the electrospun nanofibers .…”

Chitosan‐laponite nanocomposite scaffolds for wound dressing application

“…When a skin injury occurs, the healing process begins, involving a complex sequence of events such as hemostasis, inflammation, granulation, and tissue remodeling. Skin lesions may be acute, such as abrasions, cuts, penetration of objects, surgical incisions, burns, shocks, and contact with corrosive substances or chronic (diabetes, persistent infections, thrombosis, and edema) (Zarrintaj et al, ).…”

“…Despite assorted types of wound dressings available, only a few fulfill an ideal wound dressing characteristics such as provide protection on the injured site, absorption of wound exudates, allow exchange of gases and promote the acceleration of the tissue repair process (Boateng, Matthews, Stevens, & Eccleston, ; Zarrintaj et al, ). Therefore, the development of an ideal wound dressing or modern wound dressing is a growing field that offers new perspectives in the treatment of skin lesions and it has been focused to achieve the ideal wound dressing containing the aforementioned properties.…”