Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?

Dickson, Diane M.; Smith, Stephanie L.; Hendry, Gordon J

doi:10.1016/j.knee.2020.12.011

Cited by 3 publications

(2 citation statements)

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“…Previous literature[ 8 - 10 ] suggests that ultrasound elastography may have potential value in determining the pathological reactivity of malignant tumors after NAC, as patients with low elasticity scores were more likely to achieve complete tumor remission. Other studies[ 11 , 12 ] also suggested that the hardness of the tissue in breast cancer evaluated by ultrasound elastography was closely related to NAC reactivity.…”

Section: Discussionmentioning

confidence: 99%

Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography

Pan¹,

Zhang²,

Wu³

et al. 2022

WJCC

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BACKGROUND The incidence of breast cancer in China is increasing while its mortality rate is decreasing. The annual breast cancer incidence in China is 39.2 million, accounting for two-thirds of the urban population. In China, breast cancer is the fifth most common malignant tumor overall and the most common in women, accounting for 17% of female malignant tumors. AIM To investigate the accuracy of strain ultrasound elastography (SUE) on the evaluation of preoperative neoadjuvant chemotherapy (NAC) in breast cancer. METHODS Overall, 90 patients with breast cancer treated at our hospital between January 2018 and February 2019 were selected for this study. The patients received six cycles of NAC with docetaxel, epirubicin, and cyclophosphamide. Surgical treatment was also performed, and pathological reactivity was assessed. The patients were evaluated using conventional ultrasonography and SUE before biopsy. The differences between groups were analyzed to calculate the mean and standard deviation with significance measured using a t -test, while multivariate analysis was performed using logistic regression analysis. RESULTS Of the patients analyzed, 20 had a pathological complete remission (pCR) while 70 did not achieve pCR after NAC. The ratio of the elastic strain ratio (SR) and elastic score of 4–5 in patients with pCR were 5.5 ± 1.16 and 15.00%, respectively; these were significantly lower than those in patients without pCR (85%) and significantly higher than in patients without pCR (14%). SR and elastic score 4–5 were independent factors influencing NAC efficacy (OR=0.644, 1.426 and 1.366, respectively, P < 0.05). SR was positively correlated with elasticity score (r s = 0.411, P < 0.05). The area under the receiver operator characteristic curve of SR and SR combined with elastic score in predicting patients without pCR was 0.822 and 0.891, respectively ( P < 0.05). CONCLUSION Strain ultrasonic elastography may be used to evaluate the effects of preoperative NAC in patients with breast cancer.

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Section: Discussionmentioning

confidence: 99%

Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography

Pan¹,

Zhang²,

Wu³

et al. 2022

WJCC

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“…Common SE measurement methods include colour scoring (CS), where a colour-coded elastogram represents different magnitudes of relative tissue strain. Elasticity ratio (ER) can also be employed to demonstrate elastic contrast through semi-quantitative assessment of two defined regions of interest (ROI) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon

2022

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An advanced ultrasound imaging technique, sonoelastography (SE) is used to evaluate tissue elasticity. To determine SE potential to detect pathological-related changes, and characteristics related to tendon pathology we aimed to (1) compare quadriceps and patellar tendon findings in individuals with knee osteoarthritis (KOA) and asymptomatic older adults (AC), and (2) explore associations between SE, participant characteristics (age, BMI, and leg circumference) and KOA status. 84 participants (47; KOA and 37; asymptomatic older adults) underwent SE examination of quadriceps (distal) and patellar (distal, proximal) tendon in a supine position with the knee bent at 30°. Colour score (CS) and Elasticity Ratio (ER) analysis were performed by a blinded experienced operator using Esaote Mylab 70 XVG Ultrasound equipment. Significantly reduced elasticity in the distal quadriceps (median (IQR) 2(2), 3(1), p = 0.033 for KOA and AC, respectively) and proximal patellar (3(1), 3(0), p = 0.001) tendons and more elastic distal patellar (1.50 (0.55), 1.87 (0.72), p = 0.034) tendons were observed in the KOA group. Significant associations) were identified between SE and participant BMI (Rs = − 0.249–0.750, p < 0.05) and leg circumference (Rs = − 0.260–0.903, p < 0.05). Age, BMI and KOA status, were independent explanatory variables of SE CS findings at the distal quadriceps tendon patellar tendon, proximal patellar tendon and distal patellar tendon, explaining 66%, 81% and 64% of variance, respectively. Age, BMI and KOA status were independent explanatory variables of SE ER findings at the distal patellar tendon explaining 19% of variance. Potentially clinically relevant altered tendon stiffness were observed between individuals with KOA and asymptomatic controls. Key KOA risk factors and participant characteristics explained variance in tendon stiffness. Findings provide context for future studies to investigate the potential for targeted SE detected early clinical management based on associated participant characteristics.

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Excellent reversibility of resistive nanocomposite strain sensor composed of silver nanoflowers, polyurethane, and polyester rubber band

Kim

Faseela

Yang

et al. 2022

Composites Science and Technology

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Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?

Cited by 3 publications

References 48 publications

Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography

Preoperative neoadjuvant chemotherapy in patients with breast cancer evaluated using strain ultrasonic elastography

Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon

Excellent reversibility of resistive nanocomposite strain sensor composed of silver nanoflowers, polyurethane, and polyester rubber band

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