Can mesenchymal stem cell lysate reverse aging?

Hsu, Ming; Yu, Szu Hsien; Chuang, Sheng Jie; Kuo, Tom Ming-Ching; Singal, Pawan K.; Huang, Chih Yang; Kao, Chung Lan; Kuo, Chia-Hua

doi:10.18632/aging.101595

Cited by 5 publications

(36 citation statements)

References 33 publications

(36 reference statements)

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“…Eleven published studies use cellular lysate derived from mesenchymal stromal cells from different origins to treat diverse conditions. The studies investigate the lysate's effect on aging [65], erectile dysfunction [66], fulminant hepatic failure [67], stroke [68], osteosarcoma and mammary carcinoma [69], epilepsy [70], liver failure [71], wound healing [72], ischemia [73], lymphoma [74], and obesity [75]. All of the aforementioned studies except the study investigating its effects on aging demonstrated that the lysate was able to ameliorate in vitro and in vivo models.…”

Section: Live Cells Dead Cells and Derivativesmentioning

confidence: 99%

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

Goodman

Davies

2020

FEBS Open Bio

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Autoimmune pancreatitis, a derivative of chronic pancreatitis, frequently causes acute episodes with clinical symptoms parallel to those of acute pancreatitis. Corticosteroids are effective in the treatment of 90% of autoimmune pancreatitis cases, but for the remaining 10%, options are limited. Due to their significant immunomodulatory capabilities, mesenchymal stromal cells (MSCs) have been proposed as a novel treatment strategy for various immune and inflammatory pathologies including those with autoimmune origins. Here, we not only highlight the most recent MSC live‐cell experiments to address acute pancreatitis, but also discuss the opportunities afforded by the emergence of the newly identified field of MSC necrobiology. We conclude that the putative employment of MSC derivatives provides a newer and simpler therapeutic approach that could have significant advantages over the use of cells themselves.

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Section: Live Cells Dead Cells and Derivativesmentioning

confidence: 99%

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

Goodman

Davies

2020

FEBS Open Bio

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“…To assess physical vitality of the animals, spontaneous locomotor activity was monitored using a Locoscan video tracking system (Clever Sys, VA, USA) on a black plastic cage (40 cm × 40 cm). 15 One week prior to assessment, rats were familiarized to the plastic cage for 10 min/day with spontaneous locomotive activity measured in quiet and dark environments. Rats were placed in the center of the plastic cage and allowed to move freely.…”

Section: Spontaneous Locomotive Activitymentioning

confidence: 99%

Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals

Saovieng

Jean

et al. 2020

Cancer Med

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Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P < .05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P < .05) but not during later life.X-ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced-to-oxidized glutathione ratio (GSH/ GSSG) declined with age for the first three quarters of life on all groups (P < .05), followed by a resurgence during end-life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM

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Can mesenchymal stem cell lysate reverse aging?

Cited by 5 publications

References 33 publications

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals

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