Can Left Ventricular Noncompaction Be Acquired, and Can It Disappear?

Angelini, Paolo

doi:10.14503/thij-17-6389

Cited by 2 publications

(1 citation statement)

References 15 publications

(13 reference statements)

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“…The etiology of acquired LVNC is merely speculative. One such hypothesis argues that mild LVNC can remain undetected until transient LV dilation allows LVNC to become visible under precise and accurate imaging [51]. It is also speculated that acquired LVNC may be due to cardiac remodeling from increased preload and altered hemodynamics [29].…”

Section: Gross Morphopathologic Appearance Of Lvnc a Heart From A Individual With Left Ventricular Noncompaction Note The Spongy Appearanmentioning

confidence: 99%

Left Ventricular Noncompaction Cardiomyopathy: From Clinical Features to Animal Modeling

Purevjav¹,

Chintanaphol²,

Orgil³

et al. 2022

Preclinical Animal Modeling in Medicine

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Cardiomyopathy or disease of the heart muscle involves abnormal enlargement and a thickened, stiff, or spongy-like appearance of the myocardium. As a result, the function of the myocardium is weakened and does not sufficiently pump blood throughout the body nor maintain a normal pumping rhythm, leading to heart failure. The main types of cardiomyopathies include dilated hypertrophic, restrictive, arrhythmogenic, and noncompaction cardiomyopathy. Abnormal trabeculations of the myocardium in the left ventricle are classified as left ventricular noncompaction cardiomyopathy (LVNC). Myocardial noncompaction most frequently is observed at the apex of the left ventricle and can be associated with chamber dilation or muscle hypertrophy, systolic or diastolic dysfunction, or both, or various forms of congenital heart disease. Animal models are incredibly important for uncovering the etiology and pathogenesis involved in this disease. This chapter will describe the clinical and pathological features of LVNC in humans and present the animal models that have been used for the study of the genetic basis and pathogenesis of this disease.

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Section: Gross Morphopathologic Appearance Of Lvnc a Heart From A Individual With Left Ventricular Noncompaction Note The Spongy Appearanmentioning

confidence: 99%