Can individualized-targeted computerized cognitive training improve everyday functioning in adults with HIV-associated neurocognitive disorder?

Vance, David E.; Fazeli, Pariya L; Azuero, Andres; Frank, Jennifer Sandson; Wadley, Virginia G.; Raper, James L.; Pope, Caitlin N.; Ball, Karlene K.

doi:10.1080/23279095.2021.1906678

Cited by 9 publications

(31 citation statements)

References 44 publications

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“…We found limited support for the impact of the intervention on functional measures, with a moderate effect size but non-significant results for the Medication Management Test but no evidence of an effect on the UPSA. This is similar results reported by Vance et al (2021) who found limited effects of cognitive training on various measures of everyday function.…”

Section: Discussionsupporting

confidence: 92%

Computer-Delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients With HIV-Associated Neurocognitive Disorder: A Randomized Trial

Ownby

Kim

2021

Front. Aging Neurosci.

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Objective: HIV infection is associated with impaired cognition, and as individuals grow older, they may also experience age-related changes in mental abilities. Previous studies have shown that computer-based cognitive training (CCT) and transcranial direct current stimulation (tDCS) may be useful in improving cognition in older persons. This study evaluated the acceptability of CCT and tDCS to older adults with HIV-associated neurocognitive disorder, and assessed their impact on reaction time, attention, and psychomotor speed.Methods: In a single-blind randomized study, 46 individuals with HIV-associated mild neurocognitive disorder completed neuropsychological assessments and six 20-min training sessions to which they had been randomly assigned to one of the following conditions: (1) CCT with active tDCS; (2) CCT with sham tDCS, or (3) watching educational videos with sham tDCS. Immediately after training and again 1 month later, participants completed follow-up assessments. Outcomes were evaluated via repeated measures mixed effects models.Results: Participant ratings of the intervention were positive. Effects on reaction time were not significant, but measures of attention and psychomotor speed suggested positive effects of the intervention.Conclusion: Both CCT and tDCS were highly acceptable to older persons with HIV infection. CCT and tDCS may improve cognitive in affected individuals.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [NCT03440840].

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Section: Discussionsupporting

confidence: 92%

Computer-Delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients With HIV-Associated Neurocognitive Disorder: A Randomized Trial

Ownby

Kim

2021

Front. Aging Neurosci.

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show abstract

“…We found limited support for the impact of the intervention on functional measures, with a moderate effect size but nonsignificant results for the Medication Management Test but no evidence of an effect on the UPSA. This is similar results reported by Vance et al (2021) who found limited effects of cognitive training on various measures of everyday function.…”

Section: Discussionsupporting

confidence: 92%

Computer-delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients with HIV-associated Neurocognitive Disorder: A Randomized Trial

Ownby

Kim

2021

Preprint

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Objective: HIV infection is associated with impaired cognition, and as individuals grow older, they may also experience age-related changes in mental abilities. Computer-based cognitive training (CCT) and transcranial direct current stimulation (tDCS) have both shown promise in improving cognition. This study evaluated the acceptability of CCT and tDCS to older adults with HIV-associated neurocognitive disorder, and assessed their impact on reaction time, attention, and psychomotor speed. Methods: In a single-blind randomized study, 46 individuals with HIV-associated mild neurocognitive disorder completed neuropsychological measures and six 20-minute training sessions, receiving (1) CCT with active tDCS; (2) CCT with sham tDCS, or (3) watching educational videos with sham tDCS. Immediately after training and again one month later, participants completed follow-up assessments. Outcomes were evaluated via repeated measures mixed effects models. Results: Participant ratings of the intervention were positive. Effects on reaction time were not significant, but measures of attention and psychomotor speed suggested positive effects of the intervention. Conclusion: Both CCT and tDCS were well accepted by older persons with HIV infection. CCT and tDCS may improve cognitive in affected individuals.

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“…Of those, 1019 records were excluded based on titles and abstracts, and 24 full-text articles were assessed for eligibility. After exclusions, 12 eligible RCTs [40][41][42][44][45][46][47][48][49][54][55][56] were selected for inclusion in the meta-analysis.…”

Section: Search Resultsmentioning

confidence: 99%

“…Studies included data from the US, 40,41,44,[46][47][48][49][54][55][56] Uganda, 42 and Italy, 45 comprising 596 total participants (320 participants in the CCT group and 276 participants in the control group).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…56 Training frequency ranged from 2 sessions per week 41,42,46 to 4 sessions per week, 48 total number of training hours ranged from 1.7 54 to 20.0, 55,56 and time since training ranged from 3 weeks 54 to 24 weeks. 45 Although all 12 studies [40][41][42][44][45][46][47][48][49][54][55][56] used CCT programs, the intervention tools were different. Cody et al, 41 Fazeli et al, 49 and Pope et al 48 used the same cognitive training program (BrainHQ.com; Posit Science) along with transcranial direct current stimulation (tDCS).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Evaluation of Computerized Cognitive Training and Cognitive and Daily Function in Patients Living With HIV

Wei

Hou

et al. 2022

JAMA Netw Open

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IMPORTANCEIn the era of antiretroviral therapy (ART), the incidence of HIV-associated neurocognitive disorder (HAND) has not yet been controlled. With the exception of ART, there is no beneficial pharmacologic treatment. However, some studies have reported that computerized cognitive training (CCT) programs may improve cognitive function among people living with HIV. OBJECTIVE To examine the association between CCT programs and 8 domains measuring cognitive function (7 domains) and daily function (1 domain) among people living with HIV.

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Can individualized-targeted computerized cognitive training improve everyday functioning in adults with HIV-associated neurocognitive disorder?

Cited by 9 publications

References 44 publications

Computer-Delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients With HIV-Associated Neurocognitive Disorder: A Randomized Trial

Computer-Delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients With HIV-Associated Neurocognitive Disorder: A Randomized Trial

Computer-delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients with HIV-associated Neurocognitive Disorder: A Randomized Trial

Evaluation of Computerized Cognitive Training and Cognitive and Daily Function in Patients Living With HIV

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