“…reduced patient side effects and decreases in antibiotic resistance levels), lack of organizational/stakeholder readiness for change, and the low compatibility with existing values and social norms of clinical staff and patients. [11][12][13] It is increasingly clear that the success of diagnostic algorithms, educational programs, and decision support tools will depend on the local context. The need for local tailoring of interventions targeting antibiotic overuse creates fundamental challenges to our traditional scientific approach, testing standardized interventions across multiple sites to define a common (or average) effect size.…”