2017
DOI: 10.1111/acel.12663
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Abstract: SummaryIt was recently reported that the extragonadal actions of follicle‐stimulating hormone (FSH) include regulation of brown and white adipose tissue function and thermogenesis. Based on these findings and on our evidence for reduced FSH levels and enhanced thermogenesis in long‐lived growth hormone (GH)‐deficient mice and GH‐resistant mice, we suggest that FSH may have a role in the control of aging and longevity. We speculate that alterations in FSH secretion may represent one of the mechanisms of trade‐o… Show more

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Cited by 7 publications
(7 citation statements)
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References 16 publications
(22 reference statements)
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“…Namely, Ames and Laron dwarf mice, which are deficient in the pituitary transcription factor PROP1 and growth hormone receptor, respectively, display reduced serum FSH, in addition to other pituitary hormones. These mice display increases in brown adipose tissue, similar to what we have reported using our anti-FSH antibody (Bartke et al 2013, Bartke 2017, Liu et al 2017. In addition, there is an impressive increase in lifespan and reduced biological aging in these mice.…”
Section: Fsh and The Biology Of Agingsupporting
confidence: 85%
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“…Namely, Ames and Laron dwarf mice, which are deficient in the pituitary transcription factor PROP1 and growth hormone receptor, respectively, display reduced serum FSH, in addition to other pituitary hormones. These mice display increases in brown adipose tissue, similar to what we have reported using our anti-FSH antibody (Bartke et al 2013, Bartke 2017, Liu et al 2017. In addition, there is an impressive increase in lifespan and reduced biological aging in these mice.…”
Section: Fsh and The Biology Of Agingsupporting
confidence: 85%
“…Aside from what is now emerging as a critical function for high plasma FSH in causing physiologic perturbations of menopause, there has also been recent speculation for its role in the aging process per se in both sexes (Bartke 2017). Even in men, serum FSH levels rise by 3% per annum (Feldman et al 2002).…”
Section: Fsh and The Biology Of Agingmentioning
confidence: 99%
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“…The SNP rs6166 in the follicle-stimulating hormone (FSH) receptor (FSHR), where asparagine 680 is changed by a serine, was linked in women with a higher probability of living more than 90 years, possibly due to lower fertility and according to the longevity–fertility trade-off hypothesis (Corbo et al 2013 ). Coupled with this, the reduction in FSH levels causes the activation of BAT, the browning of the white adipose tissue (WAT) and a higher energy expenditure that are associated with important extensions of health and longevity (Liu et al 2017 ; Bartke 2017 ).…”
Section: Gpcr Influencing Lifespanmentioning
confidence: 99%
“…Moreover, studying the effect of inhibin on the survival of other cell types and model organisms could explain its mechanisms of action and potentially lead to the development of a novel intervention with a similar mode of action. The data showing that inhibin levels decrease with age [ 62 , 63 ] and that follicle-stimulating hormone levels increase with age contributing to the process of aging [ 64 ] indicates that the role of inhibin in aging could have been overlooked.…”
Section: Introductionmentioning
confidence: 99%