Can Eucalyptol Replace Antibiotics?

Mączka, Wanda; Duda-Madej, Anna; Górny, Aleksandra; Grabarczyk, Małgorzata; Wińska, Katarzyna

doi:10.3390/molecules26164933

Cited by 50 publications

(40 citation statements)

References 86 publications

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“…Most importantly, several naphthalene containing drugs with a broad spectrum of biological activities are approved by the FDA and are available as therapeutics [ 47 ]. Closely, eucalyptol has been latterly proposed as an excellent natural replacer for antibiotics due to its powerful bactericidal activity against a wide range of potential pathogenic Gram (+) and Gram (−) bacteria [ 49 ]. Moreover, eucalyptol has also shown remarkable synergistic interaction with traditional antibiotics such as amoxicillin and gentamicin, suggesting its combination therapeutic benefit in cases of MDR and mixed-bacterial infections [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

Al-Mijalli

Assaggaf

Qasem

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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This work evaluated in vitro antioxidant, antidiabetic, and antibacterial properties of Salvia officinalis (S. officinalis) and Mentha suaveolens (M. suaveolens) essential oils (EO). The EOs were extracted, and their chemical composition was determined using GC-MS analysis. The in vitro antioxidant, antidiabetic, and antibacterial activities of S. officinalis and M. suaveolens EO were shown to be remarkable. Furthermore, S. officinalis EO demonstrated better antioxidant findings (using DPPH, ABTS, and FRAP test) than M. suaveolens EO ( p < 0.5 ). There were no significant differences in the inhibitory effects of the EOs on α-amylase and α-glucosidase activities in the antidiabetic assays. All of the examined bacterial strains (10 different strains), with the exception of P. aeruginosa, demonstrated significant sensitivity to the tested EOs, with M. suaveolens EO exhibiting better activity than S. officinalis EO. Thus, the research indicated that EO from these two medicinal plants has considerable potential for application in the formulation of antibacterial, antioxidant, and antidiabetic pharmaceuticals. However, more research studies are required to interpret the pharmacologic action of the studied EOs and their principal constituents and to confirm their safety.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

Al-Mijalli

Assaggaf

Qasem

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…One of the major ingredients of the Eucalyptus leaf oil is 1,8-cineole (Eucalyptol). It is a cyclic ether with an empirical formula C 10 H 18 O. Eucalyptol determines the commercial value of Eucalyptus essential oil for various industries [71]. Recent studies have demonstrated the tremendous potential of Eucalyptol and its antimicrobial properties (reviewed in [71]).…”

Section: Factors Influencing the Essential Oil Composition Of Plantsmentioning

confidence: 99%

“…It is a cyclic ether with an empirical formula C 10 H 18 O. Eucalyptol determines the commercial value of Eucalyptus essential oil for various industries [71]. Recent studies have demonstrated the tremendous potential of Eucalyptol and its antimicrobial properties (reviewed in [71]). It's percent and antibacterial activity depends on the specific species [1,19].…”

Section: Factors Influencing the Essential Oil Composition Of Plantsmentioning

confidence: 99%

Phytochemical Properties and Diverse Beneficial Roles of Eucalyptus globulus Labill.: A Review

Shala

Gururani

2021

Horticulturae

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Eucalyptus globulus Labill. is one of the most widely utilized medicinal plants throughout the world due to its wide spectrum of interesting biological activities that are mainly attributed to the diversity of phytochemical constituents in the plant parts. The emerging crisis of pathogen resistance for conventional antibiotics is considered a global concern for the diminishing effectiveness of antibiotics; hence, there is an urgent need to explore new antimicrobial ingredients from botanical sources, among which the most promising sources are medicinal plants. Moreover, the growing limitation toward synthetic antioxidants motivated the scientific community all over the world to identify plant-acquired antioxidants and antimicrobials. This is a huge global challenge, because of the increasing public health awareness and reliance on natural compounds, as these compounds are safer alternatives. Moreover, the undesirable impacts of synthetic pharmaceuticals can be avoided. Furthermore, plant extracts and their oil could be used as eco-friendly plant-based products for insects, weeds, and plant pathogen control, which will diminish the dependence on synthetic chemicals. Thus, this review is to highlight the richness of the E. globulus plant, with precious bioactive constituents, antioxidants, antimicrobials, and phytoremediation, and herbicidal activities, which will pave the way to the development of new pharmaceuticals and agrochemicals, as well as food preservatives. They may also provide potential commercial applications to counteract the limitations of synthetic antioxidants.

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“…Eucalyptol (1,8-Cineole) is known for its strong antimicrobial activity, and it might be an excellent alternative to synthetic drugs in the treatment of diseases, including infectious diseases [ 79 ]. Aldoghaim et al determined the antimicrobial activity of the EOs from several west Australian species of Eucalyptus [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…Eucalyptol (1,8-Cineole) is known for its strong antimicrobial activity, and it might be an excellent alternative to synthetic drugs in the treatment of diseases, including infectious diseases [79]. Aldoghaim The Eucalyptus EOs showed variable antimicrobial activity against the different microorganisms tested with the MIC values ranging from 0.25% to 8.0% (v/v) determined by the broth microdilution assay.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Essential Oils and Supercritical CO2 Extracts of Arctic Angelica (Angelica archangelica L.), Marsh Labrador Tea (Rhododendron tomentosum) and Common Tansy (Tanacetum vulgare)—Chemical Compositions and Antimicrobial Activities

et al. 2021

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Traditionally, arctic Finnish Angelica (Angelica archangelica L.), marsh Labrador tea (Rhododendron tomentosum, syn. Ledum palustre) and common tansy (Tanacetum vulgare) have been used as medicinal herbs in folklore medicine. However, these underutilised plants are a source of, e.g., oil-based compounds, which could benefit many modern applications implemented by the green chemistry extraction methods, as well. We extracted Angelica, marsh Labrador tea and common tansy by non-toxic and recyclable extraction methods, i.e., hydrodistillation and supercritical carbon dioxide (scCO2) extraction; characterised the essential oils (EOs) and scCO2 extracts by combination of gas chromatography and mass spectrometry (GC-MS), and in addition, analysed the antimicrobial properties. As expected for Angelica root and common tansy inflorescence, the scCO2 extraction method produced less amount of volatile compounds compared to hydrodistillation. On the other hand, more coumarins, alkanes, fatty alcohols and fatty acids were obtained. Additionally, sesquiterpenoids palustrol and ledol were predominant compounds in both marsh Labrador tea EO and scCO2 extract. According to our results, however, all the EOs and scCO2 extracts showed broad spectrum of antimicrobial activities against the selected microbes, but the effects were extract-specific. The strongest and broadest antimicrobial activities were performed by marsh Labrador tea scCO2 extract, which showed extremely strong effect on Staphylococcusaureus subsp. aureus and strong effect on Candida albicans.

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Can Eucalyptol Replace Antibiotics?

Cited by 50 publications

References 86 publications

Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

Phytochemical Properties and Diverse Beneficial Roles of Eucalyptus globulus Labill.: A Review

Essential Oils and Supercritical CO2 Extracts of Arctic Angelica (Angelica archangelica L.), Marsh Labrador Tea (Rhododendron tomentosum) and Common Tansy (Tanacetum vulgare)—Chemical Compositions and Antimicrobial Activities

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