2008
DOI: 10.1055/s-2008-1038731 View full text |Buy / Rent full text
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Abstract: It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury.

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“…Future studies will be required to see how integrin-RyR2 binding might be related to this phenotype. Further, it has been reported that dantrolene, which stabilizes RyR2, can attenuate I/R injury in various organs, including heart (61)(62)(63). Given this prior work, combined with our current findings, we suggest that β1D integrin contributes to RyR2 channel interdomain stabilization in the myocyte and, as above, in doing so can affect [Ca 2+ ] microdomain availability within the myocyte.…”
Section: Figuresupporting
“…2005). It was hypothesized that this drug would have a neuroprotective effect by reducing the progression of secondary injury mechanisms after SCI (Kocogullari et al. 2008; Aslan et al.…”
Section: Discussionmentioning
“…(2002) examined the role of intracellular calcium in mediating posttraumatic abnormalities in axonal conduction and demonstrated that dantrolene improved electrophysiological recovery in an in vitro model of compressive injury to an isolated spinal cord dorsal column segment. Most recently, dantrolene afforded neuroprotection by antioxidative status in a model of spinal cord ischaemia/reperfusion injury induced by abdominal aortic occlusion in rabbits (Kocogullari et al. 2008) and in a traumatic ballon model, also in rabbits, that showed decreased TUNEL‐positive cells counting after dantrolene injection (Aslan et al.…”
Section: Discussionmentioning
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“…Seus efeitos neuroprotetores em modelos de trauma espinhal ex vivo, in vivo e in vitro já foram demonstrados (Thorell et al 2002, Kocogullari et al 2008, Aslan et al 2009). Recentemente, nosso grupo de pesquisa demonstrou, pela primeira vez, o potencial efeito neuroprotetor do dantrolene por inibição de apoptose neuronal em modelo in vivo de trauma espinhal agudo (TEA) (Torres et al 2010a).…”
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