Can Continuous Positive Airway Pressure Therapy Improve the General Health Status of Patients With Obstructive Sleep Apnea?

Sin, Don D.; Mayers, Irvin; Man, Godfrey C.W.; Ghahary, A.; Pawluk, Lawrence

doi:10.1378/chest.122.5.1679

Cited by 54 publications

(30 citation statements)

References 25 publications

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“…The results of this study also indicate that compliant CPAP treatment has an impact on patients' quality of life, mood and daytime sleepiness, in accordance with other studies indicating that long-term adherence to CPAP therapy improves symptoms, functional status, depressive symptoms and vigilance in patients with OSAHS [57][58][59][60]. It should be noted that the questionnaire scores improved significantly even with the relatively low levels of CPAP usage found in our standard group of patients.…”

Section: Discussionsupporting

confidence: 90%

Intensiveversusstandard follow-up to improve continuous positive airway pressure compliance

et al. 2014

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We aimed to compare the effect of intensive versus standard interventions on continuous positive airway pressure (CPAP) adherence 2 years after CPAP initiation, as well as on sleepiness, quality of life, depression, hospitalisation and death rate due to cardiovascular disease (CVD). 3100 patients with newly diagnosed sleep apnoea were randomised into the standard group, with usual follow-up care, or the intensive group, with additional visits, telephone calls and education. Subjective daytime sleepiness (Epworth Sleepiness Scale; ESS), quality of life (36-item Short Form Health Survey; SF-36) and the patient's level of depression (Beck Depression Inventory; BDI) were recorded before and 2 years after CPAP initiation, together with CVD hospitalisations and death rate.2 years after CPAP initiation, the intensive group used CPAP significantly more than the standard group (6.9 versus 5.2 h per night; p,0.001). ESS, SF-36 and BDI scores were also significantly better in the intensive group. Furthermore, the standard group had significantly more deaths and hospitalisations due to CVD.CPAP usage can be improved by both intensive and standard patient support. However, the patients who received intensive CPAP support had significantly better ESS, BDI and SF-36 scores, and lower cardiovascular morbidity and mortality, suggesting that an intensive programme could be worthwhile. @ERSpublications Intensive CPAP support improves sleepiness, quality of life, depression, hospitalisation and death rate

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Section: Discussionsupporting

confidence: 90%

Intensiveversusstandard follow-up to improve continuous positive airway pressure compliance

et al. 2014

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“…However, a placebo-controlled trial is not easy to carry out as a relatively large-scale study, and most placebocontrolled trials examining the effectiveness of nasal CPAP in improving QOL have been performed in relatively small numbers of OSAS patients (17,18,34). When Sin et al (36) recently demonstrated clinical effectiveness of nasal CPAP in terms of QOL as measured by the SF-36 in over 300 OSAS patients, they did not include placebo-treated controls. Finally, we confirmed that QOL in patients with severe OSAS depended on depressive status, while improvement of QOL with CPAP was associated with improvement of depression.…”

Section: Discussionmentioning

confidence: 99%

Nasal CPAP Improves the Quality of Life and Lessens the Depressive Symptoms in Patients with Obstructive Sleep Apnea Syndrome

et al. 2005

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Objective To assess changes in response to nasal continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea syndrome (OSAS) concerning excessive daytime sleepiness (EDS), depressive state, and quality of life (QOL).Patients and Methods We assessed for EDS using the Epworth sleepiness scale (ESS), for mood using The Zung self-depression scale (SDS), and for QOL using ShortForm 36 (SF-36) in 132 patients with obstructive sleep apnea syndrome (OSAS) and control subjects. Patients had severe OSAS (apnea-hypopnea index, 59.4±23.8/h) and were more hypersomnolent and depressed, and had poorer QOL than 38 age-and gender-matched controls.Results

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“…The majority of OSA patients have symptoms related to poor-quality sleep, such as excessive daytime sleepiness and tiredness, lack of concentration, memory impairment, and deterioration in quality of life [11,12]. Several studies analyzing the health-related quality of life (HRQoL) of patients with OSA syndrome have focused on the effect of CPAP treatment [13][14][15][16][17]; however, few studies have centered on the effect of OA treatment [18,19]. Therefore, we conducted a clinical effectiveness study for the purpose of determining the impact of OA therapy (with and without mandible advance) on the HRQoL of patients with OSA in our community.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of an oral appliance in the treatment of obstructive sleep apnea syndrome

et al. 2005

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The purpose of this study was to investigate the effects of an oral appliance (OA), with and without mandible advance, in the treatment of obstructive sleep apnea syndrome (OSA). Twenty-four patients diagnosed with OSA agreed to participate in this study. The patients were treated for 3 months (with a removable soft elastic silicone positioner customized with thermoplastic silicone and with a 5-mm opening). Patients were selected, using a randomized design, to receive an OA model either with (12 patients) or without advance (12 patients). Before treatment, a snoring questionnaire, the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), the Functional Outcomes of Sleep Questionnaire (FOSQ), the Epworth Sleepiness Scale (ESS), and polysomnography were completed. Fifteen subjects completed the protocol (13 men, two women). With respect to basal values, the mandible-advanced OA group presented a decrease in the mean apnea-hypopnea index (AHI) (33.8+/-4.7 versus 9.6+/-2.1; p<0.01), number of arousals per hour (33.8+/-13.9 versus 16.0+/-1.5; p<0.05), ESS score (14.7+/-5.1 versus 5.1+/-1.9; p<0.05), snoring score (15.4+/-1.9 versus 10.1+/-3.2; p<0.05), and total FOSQ score (78.1+/-22.6 versus 99.3+/-14.4; p<0.05). After treatment, the non-advanced group presented a decrease in the mean AHI (24.0+/-12.2 versus. 11.7+/-7.9; p<0.05). However, no significant differences were found in the number of arousals per hour, ESS score, snoring, and total FOSQ score in the non-advanced group. Neither study group showed significant difference in mean SF36 scores. Oral appliances, especially those that advance the mandible, offer an effective treatment for OSA.

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Can Continuous Positive Airway Pressure Therapy Improve the General Health Status of Patients With Obstructive Sleep Apnea?

Cited by 54 publications

References 25 publications

Intensiveversusstandard follow-up to improve continuous positive airway pressure compliance

Intensiveversusstandard follow-up to improve continuous positive airway pressure compliance

Nasal CPAP Improves the Quality of Life and Lessens the Depressive Symptoms in Patients with Obstructive Sleep Apnea Syndrome

Prospective evaluation of an oral appliance in the treatment of obstructive sleep apnea syndrome

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