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citations
Cited by 41 publications
(40 citation statements)
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“…It has been also demonstrated that exposure to activated leukocytes caused DNA base modifications in human cells typical of those induced by hydroxyl radical attack. 10 Our results reporting radiation-induced urinary 8-oxodG elevation in head and neck cancer patients (Table I) corroborate with a work of Haghdoost et al, 11 who observed an increase of this modification in breast cancer patients who received radiotherapy as adjuvant treatment after surgery. However, measurement of exclusively (solely) urinary excretion of the repair product(s) may be sometimes misleading because it gives no information about the oxidative steady state (rate of damage vs. repair) within cellular DNA and informs only about an average value of damage repair occurring sometimes in the past.…”
Section: Discussionsupporting
confidence: 90%
“…It has been also demonstrated that exposure to activated leukocytes caused DNA base modifications in human cells typical of those induced by hydroxyl radical attack. 10 Our results reporting radiation-induced urinary 8-oxodG elevation in head and neck cancer patients (Table I) corroborate with a work of Haghdoost et al, 11 who observed an increase of this modification in breast cancer patients who received radiotherapy as adjuvant treatment after surgery. However, measurement of exclusively (solely) urinary excretion of the repair product(s) may be sometimes misleading because it gives no information about the oxidative steady state (rate of damage vs. repair) within cellular DNA and informs only about an average value of damage repair occurring sometimes in the past.…”
Section: Discussionsupporting
confidence: 90%
“…Pathway analyses of both proteomic approaches suggest that oxidative stress response, coagulation properties and acute phase response are hallmarks of radiation sensitivity. This is in good agreement with previous studies [12,13] also indicating a difference in radiation induced oxidative stress response between these two extreme groups.…”
supporting
confidence: 93%
“…The 8-oxo-GTPase hydrolyzes the oxidized nucleotide 8-oxo-dGTP to 8-oxo-dGMP, preventing misincorporation of 8-oxo-dGTP into DNA. The 8-oxo-GMP is converted to 8-oxo-dG, which has been reported to be a urinary biomarker for oxidative DNA damage (25)(26)(27)) that correlates inversely with acute radiosensitivity in breast cancer patients (28). RAD23B targets UV radiation-induced lesions for nucleotide excision repair but may have a previously unrecognized role in repairing IR-induced base damage.…”
Section: Genes With Transcriptional Responses That Predict Radiation mentioning
confidence: 99%