Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis

Abstract

NCT01205854; Post-results.

Laboratory diagnostics and pathogenesis of rheumatoid arthritis — the past and the present

“…In addition, due to the low molecular weight, this protein can diffuse from the arthritis into the bloodstream, which makes it possible to determine the level of calprotectin in serum or plasma. A good correlation was also found between the concentration of calprotectin in the plasma and synovial fluid [24]. Higher concentrations of calprotectin have been detected in patients with rheumatoid arthritis compared to osteoarthritis or spondyloarthritis [24,[28][29].…”

“…A good correlation was also found between the concentration of calprotectin in the plasma and synovial fluid [24]. Higher concentrations of calprotectin have been detected in patients with rheumatoid arthritis compared to osteoarthritis or spondyloarthritis [24,[28][29]. Moreover, elevated levels of calprotectin have been shown in RF-positive patients than in RF-negative RA patients [29].…”

“…The focus of researchers is primarily biomarkers useful for assessing disease activity and prognosis of joint damage in patients with RA. Recently, anti-carbamylated (anti-carP) antibodies and calprotectin have been described in RA, which also appears to be promising in the diagnosis of this disease [18][19][20][21][22][23][24][25][26][27][28][29][30].…”

“…Moreover, elevated levels of calprotectin have been shown in RF-positive patients than in RF-negative RA patients [29]. Furthermore, the relationship between the level and the presence of anti-CCP and RF antibodies has been described [24]. Additionally, ACPA, RF IgM, or IgA-positive patients had higher levels of calprotectin than patients with negative RA antibodies [29].…”

“…Regarding this, it was demonstrated that the level of calprotectin correlates with disease activity and inflammation of joints in patients with RA. The relationship between calprotectin and clinical and laboratory indicators of arthritis, such as Disease Activity Score, C-reactive protein, erythrocyte sedimentation rate, or rheumatoid factor, has been demonstrated [24,[26][27]29].…”