volume 192, issue 11, P5130-5139 2014
DOI: 10.4049/jimmunol.1301677
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Zhengli Wu, Xiaochun Chen, Fang Liu, Wei Chen, Ping Wu, Adam J. Wieschhaus, Athar H. Chishti, Paul A. Roche, Wei-Min Chen, Tong-Jun Lin

Abstract: Mast cells play a central role in allergy through secretion of both preformed and newly synthesized mediators. Mast cell mediator secretion is controlled by a complex network of signaling events. Despite intensive studies, signaling pathways in the regulation of mast cell mediator secretion remain incompletely defined. Here, we examined the role of calpain in IgE-dependent mast cell activation. IgE-mediated activation of mouse bone marrow-derived mast cells (BMMCs) enhanced calpain activity. Inhibition of cal…

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