2015
DOI: 10.18632/aging.100732
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Abstract: Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, better protection against heat shock and other genotoxic insults have helped explain the pro-survival properties of CR. In this study, both in vitro and in vivo responses to heat shock were investigated using two diff… Show more

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Cited by 6 publications
(3 citation statements)
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References 40 publications
(46 reference statements)
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“…In contrast, for unclear reasons, normal aging cells gradually fail to maintain sufficient levels of adequately active HSP chaperones and consequently, gradually fail to clear toxic protein aggregates, leading to aging and a shorter life span [ 75 ]. Whereas calorie restriction has been shown to inhibit growth and tumorigenesis of B16F10 cells in vitro and in vivo , higher levels of GFP-tagged Hsp70 were reported in heat-treated and non treated calorie restricted cells, compared to AL cells [ 79 ]. Here, in terms of number of molecules per micron cube cell, we also found that AL liver cells contain about 76 less HSPA1A molecules than food restricted cells, a decrease that was, however, counterbalanced by a majority of 990 more HSPA8 molecules, sharing 90 % sequence homology with the minority of HSPA1A molecules ( Supplementary Table 1 ).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, for unclear reasons, normal aging cells gradually fail to maintain sufficient levels of adequately active HSP chaperones and consequently, gradually fail to clear toxic protein aggregates, leading to aging and a shorter life span [ 75 ]. Whereas calorie restriction has been shown to inhibit growth and tumorigenesis of B16F10 cells in vitro and in vivo , higher levels of GFP-tagged Hsp70 were reported in heat-treated and non treated calorie restricted cells, compared to AL cells [ 79 ]. Here, in terms of number of molecules per micron cube cell, we also found that AL liver cells contain about 76 less HSPA1A molecules than food restricted cells, a decrease that was, however, counterbalanced by a majority of 990 more HSPA8 molecules, sharing 90 % sequence homology with the minority of HSPA1A molecules ( Supplementary Table 1 ).…”
Section: Discussionmentioning
confidence: 99%
“…During differentiation of adult muscle stem cells, a progressive metabolic shift from glycolysis to oxidative phosphorylation occurs through the activation of mitochondria and oxidative pathways ( Relaix et al, 2021 ), although other factors could also be involved ( Abreu et al, 2020 ). It has been previously shown that the addition of mammalian CR serum to cell cultures could result in a higher tolerance to stress response, reduced cell proliferation and lower oxidative damage due to components present in the serum ( De Cabo et al, 2003 ; García-Matas et al, 2015 ; Novelle et al, 2015 ). Here, we propose that serum from CR mice could force activation of mitochondria, leading to increased oxidative metabolism and accelerated myotube differentiation of satellite cells.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, decreased energy availability is a common key player for the modulation of these pathways. For this reason, caloric restriction (CR) at the neuromotor level has been proposed as a valid therapeutic approach for the alleviation of neurodegenerative conditions (including peripheral neuropathies) [35][36][37][38]. Our group demonstrated that dietary CR activates canonical autophagic pathways by decreasing the levels of aggregated PMP22 and increasing ribophagy in TrJ/+ and in wild-type (+/+) nerves (manuscript in preparation).…”
mentioning
confidence: 99%