Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

Csiszár, Anna; Gautam, Tripti; Sоsnowska, Danuta; Tarantini, Stefano; Bánki, Eszter; Tucsek, Zsuzsanna; Tóth, Péter; Losonczy, György; Koller, Ákos; Reglődi, Dóra; Giles, Cory B.; Wren, Jonathan D.; Sonntag, William E.; Ungvári, Zoltán

doi:10.1152/ajpheart.00307.2014

Cited by 129 publications

(135 citation statements)

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“…The available evidence supports the concept that a link exists between circulating IGF-1 levels and miRNA expression (Bake et al 2014;Bates et al 2010;Fenn et al 2013;Marino et al 2010;Victoria et al 2015). Demonstration of IGF-1-dependent changes in miRNA biology in the vasculature is particularly important (Bonauer et al 2009;Chen et al 2015;Doebele et al n.d.;Hergenreider et al 2012;Kim et al 2014;Kuehbacher et al 2007;Leung et al 2013;Lovren et al 2012;O'Rourke and Olson 2011;Rotllan et al 2013;Stellos and Dimmeler 2014;Weber et al 2014;Zampetaki et al 2014) as changes in miRNA expression have been causally linked to the development of cardiovascular aging phenotypes (Boon et al 2013;Csiszar et al 2014;Ungvari et al 2013) and the pathogenesis of cardiovascular diseases (Ono et al 2011).…”

Section: Discussionmentioning

confidence: 64%

“…In brief, total RNA was isolated with a mirVana™ miRNA Isolation Kit (ThermoFisher Scientific) and was reverse transcribed using TaqMan® MicroRNA Reverse Transcription Kit as described previously (Bailey-Downs et al 2012a;Csiszar et al 2014). …”

Section: Quantitative Real-time Rt-pcrmentioning

confidence: 99%

“…Importantly, miRNAs were also reported to regulate several important aspects of endothelial biology and vascular function (Bonauer et al 2009;Chen et al 2015;Doebele et al n.d.;Hergenreider et al 2012;Kim et al 2014;Kuehbacher et al 2007;Leung et al 2013;Lovren et al 2012;O'Rourke and Olson 2011;Rotllan et al 2013;Stellos and Dimmeler 2014;Weber et al 2014;Zampetaki et al 2014). Further, age-related changes in miRNA expression were shown to contribute to the development of cardiovascular aging phenotypes (Boon et al 2013;Csiszar et al 2014;Ungvari et al 2013) and the pathogenesis of cardiovascular diseases (Ono et al 2011). Expression of miRNAs in the cardiovascular system was reported to be regulated by neuroendocrine factors (Hua et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis

Tarantini

Giles

Wren

et al. 2016

AGE

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Epidemiological findings support the concept of Developmental Origins of Health and Disease, suggesting that early-life hormonal influences during a sensitive period of development have a fundamental impact on vascular health later in life. The endocrine changes that occur during development are highly conserved across mammalian species and include dramatic increases in circulating IGF-1 levels during adolescence. The present study was designed to characterize the effect of developmental IGF-1 deficiency on the vascular aging phenotype. To achieve that goal, early-onset endocrine IGF-1 deficiency was induced in mice by knockdown of IGF-1 in the liver using Cre-lox technology (Igf1 f/f mice crossed with mice expressing albumindriven Cre recombinase). This model exhibits lowcirculating IGF-1 levels during the peripubertal phase of development, which is critical for the biology of aging. Due to the emergence of miRNAs as important regulators of the vascular aging phenotype, the effect of early-life IGF-1 deficiency on miRNA expression profile in the aorta was examined in animals at 27 months of age. We found that developmental IGF-1 deficiency elicits persisting late-life changes in miRNA expression in the vasculature, which significantly differed from AGE (2016) 38:239-258

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Section: Discussionmentioning

confidence: 64%

Section: Quantitative Real-time Rt-pcrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis

Tarantini

Giles

Wren

et al. 2016

AGE

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“…Intimal thickening, collagen deposition, and elastin fragmentation are reliable indications of adverse arterial remodeling, which are closely associated with an increase in the prevalence and severity of age‐associated quintessential cardiovascular disease such as atherosclerosis due to either a reduction of threshold or an enhancement of susceptibility to hostile stimuli, for example, hyperlipidemia 1, 3, 31. Findings from both experimental animal models and human studies indicate that CR has numerous beneficial effects on arterial structural and functional remodeling and eventually decelerates biological aging 14, 15, 16, 32, 33, 34, 35, 36, 37, 38, 39. Our current study further documents that CR effectively prevents the age‐associated arterial wall proinflammation at the molecular, cellular, and tissue levels, and preserves a more youthful phenotype in rats.…”

Section: Discussionmentioning

confidence: 99%

Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

Wang

Zhang

Zhu

et al. 2018

JAHA

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BackgroundAging exponentially increases the incidence of morbidity and mortality of quintessential cardiovascular disease mainly due to arterial proinflammatory shifts at the molecular, cellular, and tissue levels within the arterial wall. Calorie restriction (CR) in rats improves arterial function and extends both health span and life span. How CR affects the proinflammatory landscape of molecular, cellular, and tissue phenotypic shifts within the arterial wall in rats, however, remains to be elucidated.Methods and ResultsAortae were harvested from young (6‐month‐old) and old (24‐month‐old) Fischer 344 rats, fed ad libitum and a second group maintained on a 40% CR beginning at 1 month of age. Histopathologic and morphometric analysis of the arterial wall demonstrated that CR markedly reduced age‐associated intimal medial thickening, collagen deposition, and elastin fractionation/degradation within the arterial walls. Immunostaining/blotting showed that CR effectively prevented an age‐associated increase in the density of platelet‐derived growth factor, matrix metalloproteinase type II activity, and transforming growth factor beta 1 and its downstream signaling molecules, phospho‐mothers against decapentaplegic homolog‐2/3 (p‐SMAD‐2/3) in the arterial wall. In early passage cultured vascular smooth muscle cells isolated from AL and CR rat aortae, CR alleviated the age‐associated vascular smooth muscle cell phenotypic shifts, profibrogenic signaling, and migration/proliferation in response to platelet‐derived growth factor.Conclusions CR reduces matrix and cellular proinflammation associated with aging that occurs within the aortic wall and that are attributable to platelet‐derived growth factor signaling. Thus, CR reduces the platelet‐derived growth factor–associated signaling cascade, contributing to the postponement of biological aging and preservation of a more youthful aortic wall phenotype.

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“…Because of frequent fish-eating, those who are moderate in eating might reach a sufficient serum concentration of adiponectin and/or reach sufficient activation of AMPK for the prevention of visceral adiposity. In addition to the secreted proteins, energy restriction can result in the induction of microRNAs (miRNA) which are also found in the serum (21). In this regard, it is of great interest to search for the differences in the secretome of proteins and/or miRNAs among various life-styles.…”

Section: Discussionmentioning

confidence: 99%

The Frequency of Fish-Eating Could Negatively Associate with Visceral Adiposity in Those Who Eat Moderately

Oshima¹,

Rin²,

Kita³

et al. 2015

J Nutr Sci Vitaminol

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Summary Visceral fat accumulation is regarded as one of the major phenotypes of metabolic syndrome. There have not been enough data on the relationship between the fish-eating habit and visceral adiposity. A total of 94 male participants received abdominal CT for the measurement of the visceral fat area (VFA), serum sampling for the fatty acid composition and questionnaires about their life-style. We divided the participants into two groups: whether they ate their fill (group F, n570) or they ate in moderation (group M, n524).Stepwise multiple linear regression analyses showed that usual alcohol consumption and lower daily physical activity in group F, and infrequent fish-eating and frequent fat-rich deserts in group M were the significant positive correlates with the VFA. The serum eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio showed significant correlation with the frequency of fish-eating in both groups. Interestingly, in group M, the serum EPA/AA ratio negatively correlated with the VFA, while it failed in group F. In conclusion, the present data suggest that the fish-eating habit might negatively associate with visceral fat accumulation only in those who are moderate in eating in the general population.

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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

Abstract: Wren JD, Sonntag WE, Ungvari Z. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.

Cited by 129 publications

References 97 publications

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis

Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

The Frequency of Fish-Eating Could Negatively Associate with Visceral Adiposity in Those Who Eat Moderately

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