Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials

Kopeina, Gelina S.; Senichkin, Vyacheslav V.; Zhivotovsky, Boris

doi:10.1016/j.bbcan.2016.11.002

Cited by 48 publications

(45 citation statements)

References 156 publications

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“…Since a potential beneficial effect of DR after chemotherapy was documented in patients with different types of cancer [53], the molecular mechanisms uncovered in this study may apply to humans, at least in part. However, there are some issues to be solved in further studies.…”

Section: Discussionmentioning

confidence: 93%

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice

et al. 2020

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Background and Aims: Dietary restriction (DR) is a preventive strategy for obesity, metabolic syndrome, cardiovascular disease, and diabetes. Although an interconnection between obesity, metabolic syndrome, fatty liver, and hepatocellular carcinoma has been documented, the mechanism and impact of DR on steatosis-derived hepatocarcinogenesis are not fully understood. This study aimed to evaluate whether DR can prevent hepatic tumorigenesis. Methods: Male hepatitis C virus core gene transgenic (HCVcpTg) mice that develop spontaneous age-dependent insulin resistance, hepatic steatosis, and ensuing liver tumor development without apparent hepatic fibrosis, were fed with either a control diet ad libitum (control group) or 70% of the same control diet (DR group) for 15 months, and liver phenotypes were investigated. Results: DR significantly reduced the number and volume of liver tumors. DR attenu

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Section: Discussionmentioning

confidence: 93%

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice

et al. 2020

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“…Among the nutritional interventions, various beneficial effects from dietary restriction are well documented in the literature in both experimental and clinical models, such as extending the healthy life span and improving lipid metabolism . Meanwhile, dietary restriction is the most promising dietary regimen for various metabolic diseases, such as diabetes, cancer, cardiovascular disease, and obesity . In patients with diabetes and in experimental models, dietary restriction improves insulin sensitivity and retards diabetes‐related complications …”

Section: Dietary Intervention In Diabetesmentioning

confidence: 99%

“…[13] Meanwhile, dietary restriction is the most promising dietary regimen for various metabolic diseases, such as diabetes, cancer, cardiovascular disease, and obesity. [14][15][16][17] In patients with diabetes and in experimental models, dietary restriction improves insulin sensitivity and retards diabetes-related complications. [18,19] Many of the benefits of dietary restriction on diabetes in model organisms are due to protein and amino acid restriction in the diet and the stimulation of specific amino acid-sensing pathways, such as circulating fibroblast growth factor 21 (FGF-21), insulin-like growth factor, GCN2, and the mechanistic target of rapamycin (TOR).…”

Section: Dietary Intervention In Diabetesmentioning

confidence: 99%

Metabolic Regulation of Methionine Restriction in Diabetes

Yin

Ren

Chen

et al. 2018

Molecular Nutrition Food Res

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Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.

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“…[22,[24][25][26]. Moreover, CR could promote antitumor effects and inhibit metastases through the induction of autophagy and the modulation of the immune microenvironment [27][28][29]. Although CR may impact the reduction in PM-induced pulmonary injury and extra-pulmonary toxicity, the underlying mechanisms and the key pathways involved in regulation of cellular functions and integrity has yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Chen

et al. 2020

Preprint

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Background: Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined.Results: Male C57BL/6J mice were fed with a CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with a daily mean concentration (95.77 μg/m³) of PM2.5. Compared to AL-fed mice, CR-fed mice showed attenuated PM-induced pulmonary injury and extra-pulmonary toxicity characterized by reduction in oxidative stress, DNA damage and inflammation. RNA sequence analysis revealed that several pulmonary pathways that were involved in production of reactive oxygen species (ROS), cytokine production, and inflammatory cell activation were inactivated, while those mediating antioxidant generation and DNA repair were activated in CR-fed mice upon PM exposure. In addition, transcriptome analysis of murine livers revealed that CR led to induction of xenobiotic metabolism and detoxification pathways, corroborated by increased levels of urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and decreased cytotoxicity measured in an ex vivo assay.Conclusion: These novel results demonstrate, for the first time, that CR in mice confers resistance against pulmonary injuries and extra-pulmonary toxicity induced by PM exposure. CR led to activation of xenobiotic metabolism and enhanced detoxification of PM-bound chemicals. These findings provide evidence that dietary intervention may afford therapeutic means to reduce the health risk associated with PM exposure.

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Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials

Cited by 48 publications

References 156 publications

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice

Metabolic Regulation of Methionine Restriction in Diabetes

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

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