Caloric restriction

Speakman, John R.; Mitchell, Sharon E.

doi:10.1016/j.mam.2011.07.001

Cited by 646 publications

(660 citation statements)

References 656 publications

(774 reference statements)

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“…Furthermore, it is important to take into consideration that the daily activity of the INT‐exposed mice appeared to differ significantly from the MF‐exposed mice. We have previously reported an increase in daily activity in life‐long CR‐exposed mice in this cohort 41 in line with what has been reported earlier 6. Since exercise is an important factor regulating health, this feature might very likely contribute to the health improving effects induced by the INT and CR diet.…”

Section: Discussionsupporting

confidence: 90%

“…On the contrary, differential gene expression between INT and CR‐ exposed mice was due to NFE2L2 (or NRF2) activity well‐known for its antioxidant response 52, XBP1, acknowledged to mediate ER stress/apoptosis 53, 54, and the well‐established liver the liver transcription factor HNF4A 55. Remarkably, our data do not point toward the involvement of one or more of the four well‐established pathways involved in mediating the CR effect including (1) the insulin like growth factor (IGF‐1)/insulin signaling pathway, (2) the sirtuin pathway, (3) the adenosine monophosphate activated protein kinase pathway, and (4) the target of rapamycin pathway 6, 56, as upstream regulators. The expression profiles of the strongest differentially expressed genes in INT‐exposed mice are depicted in Fig.…”

Section: Resultscontrasting

confidence: 68%

“…Apart from life‐span, reduced food intake also increases health‐span. Here, the health‐promoting effect is not achieved by counteracting obesity‐related disorders, but by ameliorating a wide range of aging‐related diseases 5, 6, 7. It is worth mentioning, however, that these obesity‐ and age‐related disorders fundamentally overlap.…”

Section: Introductionmentioning

confidence: 99%

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Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Lute

Boekschoten

Dijk

et al. 2017

Molecular Nutrition Food Res

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ScopeCalorie restriction (CR) has been shown to extend life‐ and health‐span in model species. For most humans, a life‐long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can (1) provide long‐term beneficial effects and (2) counteract diet‐induced obesity in male aging mice.Methods and resultsIn this study, we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate‐fat (MF) feeding. This weekly intermittent CR significantly counteracted the adverse effects of the MF diet on mortality, body weight, and liver health markers in 24‐month‐old male mice. Hepatic gene expression profiles of INT‐exposed animals appeared much more comparable to CR‐ than to MF‐exposed mice. At 12 months of age, a subgroup of MF‐exposed mice was transferred to the INT diet. Gene expression profiles in the liver of the 24‐month‐old diet switch mice were highly similar to the INT‐exposed mice. However, a small subset of genes was consistently changed by the MF diet during the first phase of life.ConclusionWeekly intermittent CR largely, but not completely, reversed adverse effects caused by a MF diet.

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Section: Discussionsupporting

confidence: 90%

Section: Resultscontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Lute

Boekschoten

Dijk

et al. 2017

Molecular Nutrition Food Res

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show abstract

“…To attenuate these age‐associated clinical conditions, many approaches, in a variety of model organisms, have been investigated (reviewed in Fontana et al ., 2010). Although the effects of aging have been partially reversed though genetic mutations, drugs and environmental changes, calorie restriction (CR) is the only nongenetic technique that consistently increases lifespan (Tosato et al ., 2007; Speakman & Mitchell, 2011). The impacts of CR have been well documented in rodents, where it improves health span and increases lifespan (Richard Weindruch, 1988; Speakman et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

et al. 2017

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SummaryCalorie restriction (CR) remains the most robust intervention to extend lifespan and improve health span. Using a global mass spectrometry‐based metabolomic approach, we identified 193 metabolites that were significantly differentially expressed (SDE) in the livers of C57BL/6 mice, fed graded levels of CR (10, 20, 30 and 40% CR) compared to mice fed ad libitum for 12 h a day. The differential expression of metabolites also varied with the different feeding groups. Pathway analysis revealed that graded CR had an impact on carnitine synthesis and the carnitine shuttle pathway, sphingosine‐1‐phosphate (S1P) signalling and methionine metabolism. S1P, sphingomyelin and L‐carnitine were negatively correlated with body mass, leptin, insulin‐like growth factor‐ 1 (IGF‐1) and major urinary proteins (MUPs). In addition, metabolites which showed a graded effect, such as ceramide, S1P, taurocholic acid and L‐carnitine, responded in the opposite direction to previously observed age‐related changes. We suggest that the modulation of this set of metabolites may improve liver processes involved in energy release from fatty acids. S1P also negatively correlated with catalase activity and body temperature, and positively correlated with food anticipatory activity. Injecting mice with S1P or an S1P receptor 1 agonist did not precipitate changes in body temperature, physical activity or food intake suggesting that these correlations were not causal relationships.

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“…Besides the potential role of CR in mitigating oxidative stress, autophagy is also a crucial phenomenon to explain CR effects on longevity and healthy aging (Rajawat et al ., 2009; Speakman & Mitchell, 2011 and Madeo et al ., 2015). By this mechanism, different aged subcellular structures which accumulate molecular damage are degraded through a lysosomal pathway and the resulting products are released into the cytosol for recycling or to supply energy during starvation periods (Cuervo, 2004).…”

Section: Introductionmentioning

confidence: 99%

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice

et al. 2016

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SummaryCalorie restriction (CR) has been repeatedly shown to prevent cancer, diabetes, hypertension, and other age‐related diseases in a wide range of animals, including non‐human primates and humans. In rodents, CR also increases lifespan and is a powerful tool for studying the aging process. Recently, it has been reported in mice that dietary fat plays an important role in determining lifespan extension with 40% CR. In these conditions, animals fed lard as dietary fat showed an increased longevity compared with mice fed soybean or fish oils. In this paper, we study the effect of these dietary fats on structural and physiological parameters of kidney from mice maintained on 40% CR for 6 and 18 months. Analyses were performed using quantitative electron microcopy techniques and protein expression in Western blots. CR mitigated most of the analyzed age‐related parameters in kidney, such as glomerular basement membrane thickness, mitochondrial mass in convoluted proximal tubules and autophagic markers in renal homogenates. The lard group showed improved preservation of several renal structures with aging when compared to the other CR diet groups. These results indicate that dietary fat modulates renal structure and function in CR mice and plays an essential role in the determination of health span in rodents.

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Caloric restriction

Cited by 646 publications

References 656 publications

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice

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