Callosal Atrophy Parallels Decreased Cortical Oxygen Metabolism and Neuropsychological Impairment in Alzheimer's Disease

Atrophy of the Corpus Callosum in Alzheimer's Disease Versus Healthy Aging

“…AD subjects have smaller CC than HE or ID subjects, regardless of their age. This confirms reports by others, 1,12,18,20 and our results suggest that atrophic changes are accelerated above those of normal aging in AD. All sectors of the CC show atrophic changes in AD, although a decrease in the size of the anterior sector may best distinguish HE from AD subjects as shown by the significant interaction.…”

Atrophy of the Corpus Callosum in Alzheimer's Disease Versus Healthy Aging

“…AD subjects have smaller CC than HE or ID subjects, regardless of their age. This confirms reports by others, 1,12,18,20 and our results suggest that atrophic changes are accelerated above those of normal aging in AD. All sectors of the CC show atrophic changes in AD, although a decrease in the size of the anterior sector may best distinguish HE from AD subjects as shown by the significant interaction.…”

Fronto-parietal coupling of brain rhythms in mild cognitive impairment: A multicentric EEG study

“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of the article.) in accordance with preceding evidence on the functional effects of atrophy of corpus callosum [60,70,86,87,111,117]. They are also in accordance with preceding evidence on the reduction of the inter-hemispheric coupling at slow rhythms in physiological and pathological aging [1,53,114].…”

Neuroanatomy of Down Syndrome in vivo: A Model of Preclinical Alzheimer’s Disease

“…Corpus callosum area is reduced both in postmortem examination (Weis et al, 1991a) and in in-vivo MRI studies in AD patients. Corpus callosum area correlates with measures of cortical dysfunction derived from PET and EEG, supporting the notion that corpus callosum atrophy can be used as a marker of neocortical neuronal degeneration in AD (Hampel et al, 2002a;Janowsky et al, 1996;Teipel et al, 1998Teipel et al, , 1999Teipel et al, , 2002bYamauchi, et al, 1993). On this basis, we determined corpus callosum atrophy in 34 DS subjects and 32 healthy control subjects.…”

Atrophy of the Corpus Callosum in Alzheimer's Disease Versus Healthy Aging

“…AD subjects have smaller CC than HE or ID subjects, regardless of their age. This confirms reports by others, 1,12,18,20 and our results suggest that atrophic changes are accelerated above those of normal aging in AD. All sectors of the CC show atrophic changes in AD, although a decrease in the size of the anterior sector may best distinguish HE from AD subjects as shown by the significant interaction.…”

Fronto-parietal coupling of brain rhythms in mild cognitive impairment: A multicentric EEG study

“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of the article.) in accordance with preceding evidence on the functional effects of atrophy of corpus callosum [60,70,86,87,111,117]. They are also in accordance with preceding evidence on the reduction of the inter-hemispheric coupling at slow rhythms in physiological and pathological aging [1,53,114].…”

Neuroanatomy of Down Syndrome in vivo: A Model of Preclinical Alzheimer’s Disease

“…Corpus callosum area is reduced both in postmortem examination (Weis et al, 1991a) and in in-vivo MRI studies in AD patients. Corpus callosum area correlates with measures of cortical dysfunction derived from PET and EEG, supporting the notion that corpus callosum atrophy can be used as a marker of neocortical neuronal degeneration in AD (Hampel et al, 2002a;Janowsky et al, 1996;Teipel et al, 1998Teipel et al, , 1999Teipel et al, , 2002bYamauchi, et al, 1993). On this basis, we determined corpus callosum atrophy in 34 DS subjects and 32 healthy control subjects.…”

Atrophy of the Corpus Callosum in Alzheimer's Disease Versus Healthy Aging

“…AD subjects have smaller CC than HE or ID subjects, regardless of their age. This confirms reports by others, 1,12,18,20 and our results suggest that atrophic changes are accelerated above those of normal aging in AD. All sectors of the CC show atrophic changes in AD, although a decrease in the size of the anterior sector may best distinguish HE from AD subjects as shown by the significant interaction.…”

Fronto-parietal coupling of brain rhythms in mild cognitive impairment: A multicentric EEG study

“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of the article.) in accordance with preceding evidence on the functional effects of atrophy of corpus callosum [60,70,86,87,111,117]. They are also in accordance with preceding evidence on the reduction of the inter-hemispheric coupling at slow rhythms in physiological and pathological aging [1,53,114].…”

Neuroanatomy of Down Syndrome in vivo: A Model of Preclinical Alzheimer’s Disease

“…Corpus callosum area is reduced both in postmortem examination (Weis et al, 1991a) and in in-vivo MRI studies in AD patients. Corpus callosum area correlates with measures of cortical dysfunction derived from PET and EEG, supporting the notion that corpus callosum atrophy can be used as a marker of neocortical neuronal degeneration in AD (Hampel et al, 2002a;Janowsky et al, 1996;Teipel et al, 1998Teipel et al, , 1999Teipel et al, , 2002bYamauchi, et al, 1993). On this basis, we determined corpus callosum atrophy in 34 DS subjects and 32 healthy control subjects.…”