Calix[4]arene based α-aminophosphonates: Novel carriers for zwitterionic amino acids transport

Антипин, И. С.; Stoikov, Ivan I.; Pinkhassik, Evgueni; Fitseva, N. A.; Stibor, Ivan; Коновалов, А. И.

doi:10.1016/s0040-4039(97)01305-1

Cited by 83 publications

(35 citation statements)

References 7 publications

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“…Combined hydrogen bond donors and acceptors, such as α-aminophosphonate groups held by the calix [4]arene molecular platform allow the binding of hydrophilic amino acid zwitter ions with a selectivity order His > Phe, Tyr, Typ, which can slightly be influenced by the substituent in para-position [130,131].…”

Section: Ammonium Guanidium Ion and Amino Acid Recognitionmentioning

confidence: 99%

Calixarene-Based Molecules for Cation Recognition

Ludwig

Dzung

2002

Sensors

168

103

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Section: Ammonium Guanidium Ion and Amino Acid Recognitionmentioning

confidence: 99%

Calixarene-Based Molecules for Cation Recognition

Ludwig

Dzung

2002

Sensors

168

103

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“…Such calix[n]arenes have been demonstrated to form host-guest complexes with amino acids and other biomolecules and knowledge gained from these investigations informs the pharmaceutical applications [46][47][48][49]. Sulfonated calix[n]arenes are attractive for applications in drug delivery because they are highly soluble in water and readily form host-guest complexes with hydrophobic molecules in aqueous media.…”

Section: Calix[n]arenes For Drug Solubilizationmentioning

confidence: 99%

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents

Hoskins

Curtis²

2015

JNMR

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Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a wellcharacterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

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“…[4,5], which play an important role in biochemical processes. Calixarenes can also mimic natural enzyme action [6] and serve as lipophilic containers for the transport of a bioactive guest through cell membranes [7]. One of the most important routes to the synthesis of new bioactive compounds consists of functionalization of the calixarene skeleton with fragments of natural or artificial biologically active compounds [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%