Calibration-free potentiometric sensing with solid-contact ion-selective electrodes

Rousseau, Celeste R.; Bühlmann, Philippe

doi:10.1016/j.trac.2021.116277

Cited by 102 publications

(97 citation statements)

References 180 publications

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“…With the introduction of the Gr layer, the potential drifts were dramatically diminished. This may be attributed to the enhanced adhesion by the intermixed layer’s formation between the Gr contact and the ISM due to its hydrophobicity, as has been pointed out recently that hydrophobic effects play a crucial role in the minimization of potential drift( He et al, 2017 ; Nayak et al, 2017 ; Rousseau and Bühlmann, 2021 ). The surface characterization of both Cu/ISM and modified Cu/Gr/ISM interfaces was performed by electrochemical impedance spectroscopy ( Supplementary information section S-3 , Figure S-2) .…”

Section: Resultsmentioning

confidence: 94%

Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic

ElDin

El-Rahman

Zaazaa

et al. 2021

Biosensors and Bioelectronics

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The methacholine challenge test is considered to be the gold standard bronchoprovocation test used to diagnose asthma, and this test is always performed in pulmonary function labs or doctors’ offices. Methacholine (MCH) acts by inducing airway tightening/bronchoconstriction, and more importantly, MCH is hydrolyzed by cholinesterase enzyme (ChE). Recently, the American Thoracic Society raised concerns about pulmonary function testing during the COVID-19 pandemic due to recently reported correlation between cholinesterase and COVID-19 pneumonia severity/mortality, and it was shown that cholinesterase levels are reduced in the acute phase of severe COVID-19 pneumonia. This work describes the microfabrication of potentiometric sensors using copper as the substrate and chemically polymerized graphene nanocomposites as the transducing layer for tracking the kinetics of MCH enzymatic degradation in real blood samples. The in-vitro estimation of the characteristic parameters of the MCH metabolism [Michaelis–Menten constant (K m ) and reaction velocity (V max )] were found to be 241.041 μM and 56.8 μM/min, respectively. The proposed sensor is designed to be used as a companion diagnostic device that can (i) answer questions about patient eligibility to perform methacholine challenge tests, (ii) individualize/personalize medical dosing of methacholine, (iii) provide portable and inexpensive devices allowing automated readouts without the need for operator intervention (iv) recommend therapeutic interventions including intensive care during early stages and reflecting the disease state of COVID-19 pneumonia. We hope that this methacholine electrochemical sensor will help in assaying ChE activity in a "timely" manner and predict the severity and prognosis of COVID-19 to improve treatment outcomes and decrease mortality.

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Section: Resultsmentioning

confidence: 94%

Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic

ElDin

El-Rahman

Zaazaa

et al. 2021

Biosensors and Bioelectronics

View full text Add to dashboard Cite

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“…One is the potential stability and/or reproducibility caused by the ultrathin water layer and interfacial capacitance between solid contact and ISM [17][18][19][20]. Numerous efforts have been devoted to improving the properties of SC materials (such as hydrophobicity and redox capacitance with defined phase boundary potential) to address these issues [19][20][21][22][23][24][25]. The other is the leaking of ISM components leading to biological toxicity [26], particularly for medical applications.…”

Section: Introductionmentioning

confidence: 99%

Solid-Contact Potentiometric Anion Sensing Based on Classic Silver/Silver Insoluble Salts Electrodes without Ion-Selective Membrane

et al. 2021

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Current solid potentiometric ion sensors mostly rely on polymeric-membrane-based, solid-contact, ion-selective electrodes (SC-ISEs). However, anion sensing has been a challenge with respect to cations due to the rareness of anion ionophores. Classic metal/metal insoluble salt electrodes (such as Ag/AgCl) without an ion-selective membrane (ISM) offer an alternative. In this work, we first compared the two types of SC-ISEs of Cl− with/without the ISM. It is found that the ISM-free Ag/AgCl electrode discloses a comparable selectivity regarding organic chloride ionophores. Additionally, the electrode exhibits better comprehensive performances (stability, reproducibility, and anti-interference ability) than the ISM-based SC-ISE. In addition to Cl−, other Ag/AgX electrodes also work toward single and multi-valent anions sensing. Finally, a flexible Cl− sensor was fabricated for on-body monitoring the concentration of sweat Cl− to illustrate a proof-of-concept application in wearable anion sensors. This work re-emphasizes the ISM-free SC-ISEs for solid anion sensing.

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“…The invention of solid-contact ion-selective electrodes has opened an avenue covering fabrication, application, and theory in ion-sensor technology [ 1 , 2 , 3 , 4 , 5 , 6 ]. The reference electrode, a counterpart in electrochemical measurement, was initially treated as an issue of its own.…”

Section: Introductionmentioning

confidence: 99%

Solid-Contact Electrode with Composite PVC-Based 3D-Printed Membrane. Optimization of Fabrication and Performance

Bartoszewicz

Lewenstam

Migdalski

2021

Sensors

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Intense interest in reference electrode design and fabrication has recently been enriched with the application of 3D printing of electrodes with salt-loaded PVC membranes. This type of material is attractive in sensor technology and is challenging to implement in 3D. In this report, several improvements and simplifications in the technology were focused on and supported by a fundamental electrochemical characterization.

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Calibration-free potentiometric sensing with solid-contact ion-selective electrodes

Cited by 102 publications

References 180 publications

Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic

Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic

Solid-Contact Potentiometric Anion Sensing Based on Classic Silver/Silver Insoluble Salts Electrodes without Ion-Selective Membrane

Solid-Contact Electrode with Composite PVC-Based 3D-Printed Membrane. Optimization of Fabrication and Performance

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