Calendula L. species polyphenolic profile and in vitro antifungal activity

Faustino, Maria V.; Pinto, Diana; Gonçalves, María José; Salgueiro, Lígia; Silveira, Paulo; Silva, Artur M. S.

doi:10.1016/j.jff.2018.04.013

Cited by 33 publications

(42 citation statements)

References 81 publications

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“…Overall, 15 hydroxycinnamic acid derivatives were identified in the extracts of S. maritima , S. patens , and P. maritima (Table 1). These derivatives showed UV spectra consistent with what is described in the literature (Table S3) [4,12,13]. Although cinnamic acids naturally occur in the free form, in the analyzed taxa herein discussed, they appeared mainly linked to quinic acid (compounds 1 , 4 , 5 , and 10 ), which is accountable to an important chemical family, the chlorogenic acids.…”

Section: Resultssupporting

confidence: 84%

“…The assignment of the different chlorogenic acids (Table 1) was based on the hierarchical keys developed by Clifford and co-workers [14,15]. Consequently, compounds 1 and 4 were, respectively, identified as 3- O - and 5- O -caffeoylquinic acid, due to pseudomolecular ion [M-H] − at m / z 353 (Table 1) and their diagnostic ions at m / z 191 and 179 (Table S3) [4,12,14,16]. As both compounds presented a base peak at m / z 191, the discrimination between the two was made based on the secondary peaks: the isomer 3- O - presented one peak at m / z 135 [caffeic acid-H-CO 2 ] − and the isomer 5- O - at m / z 161 [caffeic acid-H-H 2 O] − (Table S3) [12].…”

Section: Resultsmentioning

confidence: 99%

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Puccinellia maritima, Spartina maritime, and Spartina patens Halophytic Grasses: Characterization of Polyphenolic and Chlorophyll Profiles and Evaluation of Their Biological Activities

Faustino

Silva

et al. 2019

Molecules

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Halophytic grasses have been recently targeted as possible sources of nutraceutical and medicinal compounds. Nonetheless, few studies have been conducted on the phytochemistry and biological activities of metabolites produced by these plants. Among these, Spartina maritima (Curtis) Fernald, Spartina patens (Aiton.) Muhl., and Puccinellia maritima (Hudson) Parl. are three halophytic grasses whose chemical composition and bioactivities are unknown. The present work broadens the knowledge on the polyphenolic and chlorophyll composition of these species identifying for the first time hydroxycinnamic acids and their derivatives, flavones, flavonols, lignans, as well as chlorophylls and xantophylls. The extracts were particularly rich in caffeic and ferulic acids as well as in trihydroxymethoxyflavone, apigenin and tricin derivatives. Interestingly, several of the identified compounds are relevant from a medicinal and nutraceutical point of view putting in evidence the potential of these species. Thus, the antioxidant, anti-acetylcholinesterase, antibacterial, and antifungal activities of the polyphenolic extracts were assessed as well as the photophysical properties of the chlorophyll-rich extracts. The results, herein presented for the first time, reinforce the nutritional and the medicinal potential of these halophytic grasses.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Puccinellia maritima, Spartina maritime, and Spartina patens Halophytic Grasses: Characterization of Polyphenolic and Chlorophyll Profiles and Evaluation of Their Biological Activities

Faustino

Silva

et al. 2019

Molecules

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“…In the case of 4,5- O -dicaffeoylquinic acid (isochlorogenic acid C) 9 ( Figure 1 ; Table 2 Rt = 13.99 min), which was isolated and characterized, the confirmation was also obtained by the injection of the pure compound. In fact, the literature is rich in these acids’ MS data due to their ubiquitous occurrence in plants [ 15 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ] and consequently, peaks at 4.35, 6.66, 7.12 and 8.55 min with [M − H] − at m / z 353 were identified as 1- O -caffeoylquinic, 4- O -caffeoylquinic, 3- O -caffeoylquinic and 5- O -caffeoylquinic acids, respectively. The 4- O -caffeoylquinic acid is easily distinguished from the others due to its characteristic MS 2 base peak at m / z 173, whereas in the other derivatives the base peak in MS 2 is at m / z 191 ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

et al. 2018

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The phenolic profile of Scabiosa stellata L., a species used in Moroccan traditional medicine, is disclosed. To obtain that profile the species extract was analyzed by ultra-high-performance chromatography coupled to photodiode-array detection and electrospray ionization/ion trap mass spectrometry (UHPLC-DAD-ESI/MSn). Twenty-five phenolic compounds were identified from which isoorientin and 4-O-caffeoylquinic acid can be highlighted because they are the major ones. The antioxidant activity was significantly controlled by the fraction type, with the n-butanol fraction showing the highest antioxidant activity (FRS50 = 64.46 µg/mL in the DPPH assay, FRS50 = 27.87 µg/mL in the ABTS assay and EC50 = 161.11 µg/mL in the reducing power assay). A phytochemical study of the n-butanol fraction was performed, and some important flavone glycosides were isolated. Among them the tamarixetin derivatives—the less common ones—can be emphasized. This phytochemical study and polyphenolic profile can be correlated with S. stellata extracts in vitro antioxidant activity. Moreover, it can be regarded as an evidence of its medicinal use and can incentivize its consumption.

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“…For example, Calendula suffruticosa subsp. algarbensis is particularly active against Aspergillus sp., against yeasts such as Cryptococcus neoformans, and also against some dermatophytes species such as Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes (19).…”

Section: Polyphenolsmentioning

confidence: 99%

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Redondo-Blanco

Fernández

López-Ibáñez

et al. 2020

Journal of Food Protection

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Synthetic food additives generate a negative perception in consumers. This fact generates an important pressure on food manufacturers, searching for safer natural alternatives. Phytochemicals (such as polyphenols and thiols) and plant essential oils (terpenoids) possess antimicrobial activities that are able to prevent food spoilage due to fungi (e.g., Aspergillus, Penicillium) and intoxications (due to mycotoxins), both of which are important economic and health problems worldwide. This review summarizes industrially interesting antifungal bioactivities from the three main types of plant nutraceuticals: terpenoids (as thymol), polyphenols (as resveratrol) and thiols (as allicin) as well as some of the mechanisms of action. These phytochemicals are widely distributed in fruits and vegetables and are very useful in food preservation as they inhibit growth of important spoilage and pathogenic fungi, affecting especially mycelial growth and germination. Terpenoids and essential oils are the most abundant group of secondary metabolites found in plant extracts, especially in common aromatic plants, but polyphenols are a more remarkable group of bioactive compounds as they show a broad array of bioactivities. HIGHLIGHTS

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Calendula L. species polyphenolic profile and in vitro antifungal activity

Cited by 33 publications

References 81 publications

Puccinellia maritima, Spartina maritime, and Spartina patens Halophytic Grasses: Characterization of Polyphenolic and Chlorophyll Profiles and Evaluation of Their Biological Activities

Puccinellia maritima, Spartina maritime, and Spartina patens Halophytic Grasses: Characterization of Polyphenolic and Chlorophyll Profiles and Evaluation of Their Biological Activities

Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

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