Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases

Abstract

The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca2+, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy–lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart–kidney interaction; the associated common causes are also discussed.

Silicon-rhodamine functionalized evocalcet probes (EvoSiR) potently and selectively label calcium sensing receptors (CaSR) in vitro, in vivo and ex vivo

“…However, the apparently ubiquitous expression of the CaSR across tissues 5 underscores the less understood roles of CaSR signaling in a wide variety of physiological processes, for instance its involvement in airway smooth muscle contractility 6 , inflammation 7 , taste modulation 8 and neuronal excitability 9,10 . Furthermore, dysfunctional CaSR signaling has been implicated in non-calcitropic diseases such as asthma 11 , colorectal inflammatory conditions such as inflammatory bowel disease (IBD) 12 as well as Alzheimer's 13 and cardiovascular disease (CVD) 14 , making this GPCR an attractive potential target for the development of novel therapeutic interventions and as possible disease marker. The recent surge in research on the possible roles of CaSR and its physiological roles therefore requires the development of versatile molecular tools to visualize, monitor and modulate CaSR.…”

Nghiên Cứu Tình Hình Bổ Sung Canxi Của Sinh Viên Dược Trường Cao Đẳng Y Tế Cần Thơ Năm Học 2022-2023

“…Khi nhắc đến canxi, chúng ta đều biết rằng canxi là dưỡng chất không thể thiếu đối với sức khỏe xương [1], [2], [3], [4]. Canxi đóng vai trò quan trọng trong đông cầm máu, duy trì hoạt động của cơ, tham gia hệ miễn dịch, dẫn truyền thần kinh và tham gia hoạt động của các hormon [5], [6].…”

Vitamin D3 Metabolism and Its Role in Temporomandibular Joint Osteoarthritis and Autoimmune Thyroid Diseases

“…IP3/DAG pathway leads to the degranulation of calcium in endoplasmic reticulum, increased intracellular calcium concentration, and finally blocks degranulation of the vesicles with PTH to the cell membrane. Thus, the secretion of PTH through parathyroids is inhibited [ 81 ].…”