Calcium phosphate ceramic surface coating via precipitation approach

Petrakova, N. V.; Кувшинова, Е. А.; Ашмарин, А. А.; Коновалов, А. А.; Egorov, A. A.; Свиридова, И. К.; Баринов, С. М.; Komlev, V. S.

doi:10.1088/1757-899x/525/1/012101

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…The obtained β-TCP powder was used to fabricate the porous ceramic granules by the method of porous polymer foam replication, as described elsewhere. − First, the ceramic slip was prepared by mixing the β-TCP powder with a gelatin-based aqueous solution. The polyurethane reticulated foams of average pore size of 0.1–0.5 mm were impregnated with a β-TCP slip.…”

Section: Experimental Proceduresmentioning

confidence: 99%

In Vitro Study of Octacalcium Phosphate Behavior in Different Model Solutions

et al. 2021

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Octacalcium phosphate (OCP), a new-generation bone substitute material, is a considered precursor of the biological bone apatite. The two-layered structure of OCP contains the apatitic and hydrated layers and is intensively involved in ion-exchange surface reactions, which results in OCP hydrolysis to hydroxyapatite and adsorption of ions or molecular groups presented in the environment. During various in vitro procedures, such as biomaterial solubility, additive release studies, or the functionalization technique, several model solutions are applied. The composition of the environmental solution affects the degree and rate of OCP hydrolysis, its surface reactivity, and further in vitro and in vivo properties. The performed study was aimed to track the structural changes of OCP-based materials while treating in the most popular model solutions of pH values 7.2−7.4: simulated body fluid (SBF), Dulbecco's phosphate-buffered saline (DPBS), supersaturated calcification solution (SCS), normal saline (NS), and Dulbecco's modified Eagle's medium (DMEM). Various degrees of OCP hydrolysis and/or precipitate formation were achieved through soaking initial OCP granules in the model solutions. Detailed data of X-ray diffraction, Fourier-transform infrared spectroscopy, atomic emission spectrometry with inductively coupled plasma, and scanning electron microscopy are presented. Cultivation of osteosarcoma cells was implemented on OCP pre-treated in DMEM for 1−28 days. It was shown that NS mostly degraded the OCP structure. DPBS slightly changed the OCP structure during the first treatment term, and during further terms, the crystals got thinner and OCP hydrolysis took place. Treatment in SBF and SCS caused the precipitate formation along with OCP hydrolysis, with a larger contribution of SCS solution to precipitation. Pre-treating in DMEM enhanced the cytocompatibility of materials. As a result, on performing the in vitro procedures, careful selection of the contact solution should be made to avoid the changes in materials structure and properties and get adequate results.

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Section: Experimental Proceduresmentioning

confidence: 99%

In Vitro Study of Octacalcium Phosphate Behavior in Different Model Solutions

et al. 2021

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“…Several studies [227][228][229], reported that the presence of albumin decreases the amount of CaP surface precipitation. However, conversely, other studies [183,216,230,231] proved the promoting effect of BSA on CaP precipitation. Moreover, a further study by Andesson et al [232] employing fibrinogen proved the stimulating effect on CaP formation.…”

Section: Metallic Substratesmentioning

confidence: 90%

The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat—Protein Template Constructs

Šupová

2020

Materials

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This review provides a summary of recent research on biomimetic and bioinspired strategies applied in the field of biomedical material engineering and focusing particularly on calcium phosphate—protein template constructs inspired by biomineralisation. A description of and discussion on the biomineralisation process is followed by a general summary of the application of the biomimetic and bioinspired strategies in the fields of biomedical material engineering and regenerative medicine. Particular attention is devoted to the description of individual peptides and proteins that serve as templates for the biomimetic mineralisation of calcium phosphate. Moreover, the review also presents a description of smart devices including delivery systems and constructs with specific functions. The paper concludes with a summary of and discussion on potential future developments in this field.

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Application of atomic absorption spectroscopy method for platinum content determination to study functionalization of bone substitute materials with anticancer drug

Volchenkova

Kazenas

Кувшинова

et al. 2019

J. Phys.: Conf. Ser.

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Methods of quantitative determination of the platinum content in high-salt solutions have been developed using atomic absorption spectroscopy (AAS). Definitions were carried out for small volume bioassays during the research of functionalization of calcium phosphate substitute materials with anticancer drug, cisplatin. The conditions for the determination of Pt in the flame were optimized. The effects of the cisplatin matrix solutions, salt components and concentrations on the Pt absorption value were found out. The relevance of application of the flame version of the AAS method was shown in order to determine the platinum content in high-salt solutions, over 200 g/l, without matrix separation in a wide range of Pt concentrations from 0.1 to 50 µg/ml. This issue was targeted through the estimation of efficiency of Pt-containing drug incorporation and its dynamics release as an application method in the development of drug delivery systems for bone tumors treatment.

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Calcium phosphate ceramic surface coating via precipitation approach

Cited by 3 publications

References 17 publications

In Vitro Study of Octacalcium Phosphate Behavior in Different Model Solutions

In Vitro Study of Octacalcium Phosphate Behavior in Different Model Solutions

The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat—Protein Template Constructs

Application of atomic absorption spectroscopy method for platinum content determination to study functionalization of bone substitute materials with anticancer drug

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