Calcium movements during excitation-contraction coupling in muscle cells

Effect of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle

“…The contractile effects of mefloquine encountered under this condition were direct effects of this compound on the rectal smooth muscle and was not indirectly mediated by an enhanced release of acetylcholine from intramural cholinergic nerve fibers to the mouse rectum, as they were unaffected by atropine sulphate. This observation shows that the agonist action of mefloquine in this tissue is dependent not only upon the presence of extracellular Channels (ROC'S), whereas KCL-induced contractions are due to depolarizing action on the plasmamembrane of the mouse rectal smooth muscle as a result of which extracellular Ca 2+ -influx occurs via Ca 2+ channels in the smooth muscle (Haddart and price, 1976).…”

Effect of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle

“…The contractile effects of mefloquine encountered under this condition were direct effects of this compound on the rectal smooth muscle and was not indirectly mediated by an enhanced release of acetylcholine from intramural cholinergic nerve fibers to the mouse rectum, as they were unaffected by atropine sulphate. This observation shows that the agonist action of mefloquine in this tissue is dependent not only upon the presence of extracellular Channels (ROC'S), whereas KCL-induced contractions are due to depolarizing action on the plasmamembrane of the mouse rectal smooth muscle as a result of which extracellular Ca 2+ -influx occurs via Ca 2+ channels in the smooth muscle (Haddart and price, 1976).…”

Effect of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle

“…The contractile effects of mefloquine encountered under this condition were direct effects of this compound on the rectal smooth muscle and was not indirectly mediated by an enhanced release of acetylcholine from intramural cholinergic nerve fibers to the mouse rectum, as they were unaffected by atropine sulphate. This observation shows that the agonist action of mefloquine in this tissue is dependent not only upon the presence of extracellular Channels (ROC'S), whereas KCL-induced contractions are due to depolarizing action on the plasmamembrane of the mouse rectal smooth muscle as a result of which extracellular Ca 2+ -influx occurs via Ca 2+ channels in the smooth muscle (Haddart and price, 1976).…”

Effect of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle

“…The contractile effects of mefloquine encountered under this condition were direct effects of this compound on the rectal smooth muscle and was not indirectly mediated by an enhanced release of acetylcholine from intramural cholinergic nerve fibers to the mouse rectum, as they were unaffected by atropine sulphate. This observation shows that the agonist action of mefloquine in this tissue is dependent not only upon the presence of extracellular Channels (ROC'S), whereas KCL-induced contractions are due to depolarizing action on the plasmamembrane of the mouse rectal smooth muscle as a result of which extracellular Ca 2+ -influx occurs via Ca 2+ channels in the smooth muscle (Haddart and price, 1976).…”