Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis

Morciano, Giampaolo; Rimessi, Alessandro; Patergnani, Simone; Vitto, Veronica Angela Maria; Danese, Alberto; Kahsay, Asrat; Palumbo, Laura; Bonora, Massimo; Wieckowski, Mariusz R.; Giorgi, Carlotta; Pinton, Paolo

doi:10.1016/j.phrs.2022.106119

Cited by 28 publications

(14 citation statements)

References 340 publications

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“…Amiodarone is a class III antiarrhythmic drug that can delay ischemic myocardial conduction and reduce the action potential of ischemic and nonischemic myocardium, thereby reducing reentrant excitation and triggered activity and helping to inhibit the occurrence of arrhythmia [ 12 ]. Clinical studies have shown that in acute myocardial ischemia or myocardial infarction, amiodarone can increase the activity of ion channels without aggravating the deterioration of cardiac function and has no effect on myocardial ischemia [ 13 , 14 ]. All kinds of arrhythmia combined in the blood have a better effect.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

Leng

Sun

Peng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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With the development and popularity of percutaneous coronary intervention (PCI), ischemia-reperfusion injury (IRI) has attracted more and more clinical attention. Reperfusion arrhythmia (RA), one of the common manifestations during and after PCI, can affect the postoperative cardiac function of patients with acute myocardial infarction (AMI). Therefore, effective intervention on RA has important clinical significance. This study observed the effect of amiodarone on reperfusion arrhythmia (RA) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) and explored its possible mechanism. The results showed that amiodarone had good clinical efficacy in the prevention of RA in patients with AMI after PCI, and it could reduce the levels of serum IL-6, hs-CRP, CK-MB, and cTnI in patients and reduce the damage caused by reperfusion, thereby reducing the occurrence of RA.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

Leng

Sun

Peng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Calcium signaling is a highly conserved, potent mechanism of signal transduction that is associated with numerous pathologies when dysregulated 35–37 . Termination of Ca 2+ signals and the maintenance of intracellular Ca 2+ homeostasis is accomplished by various pumps and channels such as SERCA, which transports cytosolic Ca 2+ back into the ER 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Calcium signaling is a highly conserved, potent mechanism of signal transduction that is associated with numerous pathologies when dysregulated. [35][36][37] Termination of Ca 2+ signals and the maintenance of intracellular Ca 2+ homeostasis is accomplished by various pumps and channels such as SERCA, which transports cytosolic Ca 2+ back F I G U R E 4 SERCA activation does not influence allergen-induced proinflammatory gene expression. RNA isolated from BMMCs stimulated for 0, 15, 30, 60, 120, and 180 min was subjected to qPCR analysis.…”

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confidence: 99%

Acute activation of SERCA with CDN1163 attenuates IgE‐mediated mast cell activation through selective impairment of ROS and p38 signaling

et al. 2023

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Mast cells are granulocytic immune sentinels present in vascularized tissues that drive chronic inflammatory mechanisms characteristic of allergic pathologies. IgE‐mediated mast cell activation leads to a rapid mobilization of Ca2+ from intracellular stores, which is essential for the release of preformed mediators via degranulation and de novo synthesized proinflammatory cytokines and chemokines. Given its potent signaling capacity, the dynamics of Ca2+ localization are highly regulated by various pumps and channels controlling cytosolic Ca2+ concentrations. Among these is sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA), which functions to maintain low cytosolic Ca2+ concentrations by actively transporting cytosolic Ca2+ ions into the endoplasmic reticulum. In this study, we characterized the role of SERCA in allergen‐activated mast cells using IgE‐sensitized bone marrow‐derived mast cells (BMMCs) treated with the SERCA activating compound, CDN1163, and simultaneously stimulated with allergen through FcεRI under stem cell factor (SCF) potentiation. Acute treatment with CDN1163 was found to attenuate early phase mast cell degranulation along with reactive oxygen species (ROS) production. Additionally, treatment with CDN1163 significantly reduced secretion of IL‐6, IL‐13, and CCL3, suggesting a role for SERCA in the late phase mast cell response. The protective effects of SERCA activation via CDN1163 treatment on the early and late phase mast cell response may be driven by the selective suppression of p38 MAPK signaling. Together, these findings implicate SERCA as an important regulator of the mast cell response to allergen and suggest SERCA activity may offer therapeutic potential targeting allergic pathologies, warranting further investigation.

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“…Calcium excess is triggered by a malfunction of the calcium balancing system and a problem of calcium transport, which results in an excessive rise in intracellular calcium levels [160,161]. Calcium excess can disrupt the mitochondrial oxidative phosphorylation pathway, reduce mitochondrial membrane potential, and activate phospholipases and proteases in the cytoplasm, resulting in permanent cell damage [162].…”

Section: Targeting Metal Ion Homeostasismentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis

Cited by 28 publications

References 340 publications

Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

Acute activation of SERCA with CDN1163 attenuates IgE‐mediated mast cell activation through selective impairment of ROS and p38 signaling

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

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