Calcium/creatinine ratio and microalbuminuria in the prediction of preeclampsia

Rodriguez, M; Masaki, Damon I.; Mestman, Jorge H.; Kumar, Dinesh; Rude, Robert E.

doi:10.1016/0002-9378(88)90573-x

Cited by 90 publications

(43 citation statements)

References 6 publications

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“…Therefore, dietary deficiency alone could not explain hypocalciuria in these patients. Even then, there was no statistically significant difference between the calcium-creatinine ratio reported in the two gestational periods studied, a result similar to that reported by Rodriguez et al 12 and Sanchez-Ramos et al 23 The predictive value of plasma fibronectin was found to be the best when compared with the other preeclampsia predictive tests used in this study. This is with regards to the sensitivity, positive and negative values in both gestational periods studied.…”

Section: Discussionsupporting

confidence: 90%

“…Microalbuminuria was used to predict pre-eclampsia development by Mostafa and Mostafa 17 and Rodriguez et al, 12 with a varying degree of sensitivity. The findings in our study showed low predictive values when compared to the other predictive tests used.…”

Section: Discussionmentioning

confidence: 99%

“…12 Total plasma fibronectin has been found to be elevated before the onset of pre-eclampsia and has been used to predict its development. 6,10,[13][14][15] Simple clinical tests have also been used to predict the disease.…”

mentioning

confidence: 99%

“…18 A combination of more than one test has been suggested, to predict more precisely the subsequent development of pre-eclampsia. 12 The aim of this study was to compare the predictive value of different tests, used separately or combined, for detecting pre-eclampsia. These tests looked for the presence of microalbuminuria, hypocalciuria, and increased plasma fibronectin in the study population.…”

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confidence: 99%

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Values of Certain Clinical and Biochemical Tests for Prediction of Pre-Eclampsia

Soltan

Ismail

et al. 1996

Ann Saudi Med

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To evaluate different predictive tests for pre-eclampsia, either individually or in combination, we prospectively studied 100 primigravid females. Eighty-eight of the subjects continued the follow-up until delivery and 17 developed pre-eclampsia. Venous blood samples were taken for determination of plasma fibronectin, and urine samples were taken for determination of microalbuminuria and calcium-creatinine ratio. Isometric handgrip exercise tests were also performed. Evaluation of predictive tests, as well as t and chi-squared statistical tests, were used for analysis of data. Pre-eclampsia developed in 19.3% of the patients studied. Pre-eclamptic and normotensive females showed significant differences in calcium-creatinine ratio and plasma fibronectin levels in both (14-24 weeks and 28-32 weeks) gestation periods (P<.0001). Plasma fibronectin had the best sensitivity, positive, and negative values in gestation period 14-24 weeks, whereas isometric handgrip exercise tests had the best specificity. These values improved for all the tests in the 28-32-week gestation period; even so, plasma fibronectin proved best of all. A combination of tests failed to improve the predictive ability of fibronectin alone. We conclude that plasma fibronectin is the best predictive test for pre-eclampsia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Values of Certain Clinical and Biochemical Tests for Prediction of Pre-Eclampsia

Soltan

Ismail

et al. 1996

Ann Saudi Med

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“…Several researchers have reported that hypocalciuria was associated with preeclampsia and could be considered a risk factor for development of preeclampsia in pregnancy 1,2,3 . Rodriquez et al 4 evaluated the role of decreasing calcium creatinine ratio and microalbuminuria in prediction of preeclampsia as early as in 1988 and have concluded that these tests may be useful screening tools in prediction of preeclampsia. Since then, several researchers have demonstrated the efficacy of decreasing urinary calcium to creatinine ratio and microalbuminuria in the prediction of preeclampsia, whereas others have not found it as useful.…”

Section: Introductionmentioning

confidence: 99%