Calcium channel blockers for primary Raynaud's phenomenon

Abstract

of findings for the main comparison. Calcium channel blockers for primary Raynauds's phenomenon Calcium channel blockers for primary Raynauds's phenomenon Patient or population: primary Raynaud's phenomenon Setting: hospital and hospital outpatient clinics Intervention: calcium channel blockers Comparison: placebo Anticipated absolute effects * (95% CI) Outcomes Risk with placebo Risk with Calcium channel blockers Relative effect (95% CI) CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Cochrane Library Trusted evidence. Informed decisions. Better health.

Finger blood flow after the cold challenge with primary Raynaud’s syndrome: a case report

“…Calcium channel blockers are commonly used for prevention of vasospasm in these patients. 7 In the present patient also, treatment with the calcium channel blocker amlodipine improved clinical symptoms of Raynaud’s phenomenon. Even after a cold challenge under the condition of treatment with amlodipine, he had no typical Raynaud’s phenomenon.…”

Finger blood flow after the cold challenge with primary Raynaud’s syndrome: a case report

“…Calcium channel blockers are commonly used for prevention of vasospasm in these patients. 7 In the present patient also, treatment with the calcium channel blocker amlodipine improved clinical symptoms of Raynaud’s phenomenon. Even after a cold challenge under the condition of treatment with amlodipine, he had no typical Raynaud’s phenomenon.…”

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial

“…[24][25][26] It is unlikely that the high prevalence of Raynaud phenomenon affected our results as placebo-controlled trials indicate that nifedipine and other calcium channel blockers are effective for treating that condition. 27 We found a remarkable reduction of chilblains symptoms during placebo treatment that may have several explanations. First, the placebo effect may have been responsible.…”

Pharmacologic Treatment of Idiopathic Chilblains (Pernio): A Systematic Review

“…A 2017 Cochrane review (38 studies, n = 982 patients), concluded that calcium channel blockers “probably slightly reduce” the frequency, severity, and overall patient assessment of raynaud’s attacks. 21 Importantly, while common side effects included headache, dizziness, nausea, palpitations, and ankle edema, there were no serious adverse events experienced by participants in any of these studies. Although the evidence for nifedipine use in the treatment of chilblains is less robust than that for raynaud’s, it is still widely prescribed.…”

Finger blood flow after the cold challenge with primary Raynaud’s syndrome: a case report

“…Calcium channel blockers are commonly used for prevention of vasospasm in these patients. 7 In the present patient also, treatment with the calcium channel blocker amlodipine improved clinical symptoms of Raynaud’s phenomenon. Even after a cold challenge under the condition of treatment with amlodipine, he had no typical Raynaud’s phenomenon.…”

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial

“…[24][25][26] It is unlikely that the high prevalence of Raynaud phenomenon affected our results as placebo-controlled trials indicate that nifedipine and other calcium channel blockers are effective for treating that condition. 27 We found a remarkable reduction of chilblains symptoms during placebo treatment that may have several explanations. First, the placebo effect may have been responsible.…”

Pharmacologic Treatment of Idiopathic Chilblains (Pernio): A Systematic Review

“…A 2017 Cochrane review (38 studies, n = 982 patients), concluded that calcium channel blockers “probably slightly reduce” the frequency, severity, and overall patient assessment of raynaud’s attacks. 21 Importantly, while common side effects included headache, dizziness, nausea, palpitations, and ankle edema, there were no serious adverse events experienced by participants in any of these studies. Although the evidence for nifedipine use in the treatment of chilblains is less robust than that for raynaud’s, it is still widely prescribed.…”

Finger blood flow after the cold challenge with primary Raynaud’s syndrome: a case report

“…Calcium channel blockers are commonly used for prevention of vasospasm in these patients. 7 In the present patient also, treatment with the calcium channel blocker amlodipine improved clinical symptoms of Raynaud’s phenomenon. Even after a cold challenge under the condition of treatment with amlodipine, he had no typical Raynaud’s phenomenon.…”

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial

“…[24][25][26] It is unlikely that the high prevalence of Raynaud phenomenon affected our results as placebo-controlled trials indicate that nifedipine and other calcium channel blockers are effective for treating that condition. 27 We found a remarkable reduction of chilblains symptoms during placebo treatment that may have several explanations. First, the placebo effect may have been responsible.…”

Pharmacologic Treatment of Idiopathic Chilblains (Pernio): A Systematic Review

“…A 2017 Cochrane review (38 studies, n = 982 patients), concluded that calcium channel blockers “probably slightly reduce” the frequency, severity, and overall patient assessment of raynaud’s attacks. 21 Importantly, while common side effects included headache, dizziness, nausea, palpitations, and ankle edema, there were no serious adverse events experienced by participants in any of these studies. Although the evidence for nifedipine use in the treatment of chilblains is less robust than that for raynaud’s, it is still widely prescribed.…”