Calcium Absorption and Plasma 25-Hydroxy-Vitamin D in Elderly Women after Oral 25-Hydroxy-Vitamin D3

Francis, RM; Storer, J.; Nordin, B. E. C.

doi:10.1042/cs059014pa

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1981

1984

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“…Plasma 25-hydroxyvitamin D falls gradually with age [9], such that over the age of 70 a substantial number of the general population have low levels, and vitamin D deficient osteomalacia may even occur. Mal absorption of calcium becomes increasingly common over the age of 60, and in the ma jority of patients it can be restored to normal by increasing the plasma 25-hydroxyvitamin D into the young normal range [10]. The fall in renal function with age has been recog nized for many years.…”

Section: Susceptibility To Fracturementioning

confidence: 99%

Senile and Postmenopausal Osteoporosis

Peacock¹,

Horsman

Marshall

et al. 1984

Horm Res

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Section: Susceptibility To Fracturementioning

confidence: 99%

Senile and Postmenopausal Osteoporosis

Peacock¹,

Horsman

Marshall

et al. 1984

Horm Res

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The vitamin D metabolites in the pathogenesis and management of osteoporosis

Crilly

Horsman

Nordin

1981

Current Medical Research and Opinion

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Studies on post-menopausal osteoporotic patients indicate that 1,25-(OH)2 D3 concentrations are no different from those in age-matched normal subjects and the data suggest that the malabsorption of calcium found in many osteoporotic patients cannot generally be attributed to low plasma 1,25-(OH)2 D3 levels. The effects are discussed of three different therapies - sex hormones alone, vitamin D metabolites alone and a combination of both - on calcium balance and peripheral bone loss in treated compared with untreated osteoporotic patients. The results indicate that combined therapy with a vitamin D metabolite and an oestrogen is more effective in inhibiting the rate of bone resorption in post-menopausal osteoporosis than treatment with either agent used alone, and should be regarded as the treatment of choice at the present time. It is suggested that, using this regimen which is suitable for patients up to about 65 years of age, calcium supplementation is not required, provided daily calcium intake is reasonably adequate, and may even be undesirable by increasing the risk of hypercalcaemia.

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Calcium Absorption and Plasma 25-Hydroxy-Vitamin D in Elderly Women after Oral 25-Hydroxy-Vitamin D3

Abstract: 2P < 0.005). The mean d,M concentration in patients with emphysema (i = 2145 f 565 mg/l) was not significantly

Cited by 2 publications

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Senile and Postmenopausal Osteoporosis

Senile and Postmenopausal Osteoporosis

The vitamin D metabolites in the pathogenesis and management of osteoporosis

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