Calcitonin for metastatic bone pain

Comparative Study Of Subarachnoid Calcitonin And Fentanyl As Adjuvant With Local Analgesic Bupivacaine For Postoperative Pain Relief: A Double Blind Study

“…This, probably, suggesting why in the present study patients with malignancy had considerably less pain in post operative period. Kalle et al (1999), Martinez et al(2003) Frauceschini R et al (1993) stated that the analgesic effect of salmon calcitonin occurs independently of its peripheral action. It has been postulated that administered calcitonin binds to its receptors located on neural elements, thereby affecting the analgesic pathway controlling pain perception or elevating the nociceptive sensitivity threshold.…”

Comparative Study Of Subarachnoid Calcitonin And Fentanyl As Adjuvant With Local Analgesic Bupivacaine For Postoperative Pain Relief: A Double Blind Study

“…This, probably, suggesting why in the present study patients with malignancy had considerably less pain in post operative period. Kalle et al (1999), Martinez et al(2003) Frauceschini R et al (1993) stated that the analgesic effect of salmon calcitonin occurs independently of its peripheral action. It has been postulated that administered calcitonin binds to its receptors located on neural elements, thereby affecting the analgesic pathway controlling pain perception or elevating the nociceptive sensitivity threshold.…”

Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases

“…Therefore, little information is available about its use in this context. However, Martinez et al (3) recently performed a systematic review of all the available data to determine the effectiveness of calcitonin in reducing metastatic bone pain. Unfortunately, only two studies (including only 90 patients in total) had the methodological quality required by the inclusion criteria.…”

“…No improvement in general performance or bone pain was detected as measured by a visual analogue scale, the daily duration of pain or consumption of analgesic drugs. The systematic review by Martinez et al (3) concluded that the available evidence was limited, did not support the use of calcitonin to control pain from bone metastases and called for new studies to provide additional information. It should be emphasized that this review did not include the randomised double-blind placebo-controlled clinical trial by Hindley et al (11) because a 4-week cut-off was a prerequisite for inclusion in the review, while the latter study was of two-week duration.…”

Update in Cancer Pain Syndromes

“…177 A Cochrane review concluded that the evidence was too limited to make a recommendation for the use of calcitonin. 178 Fractures Pathologic fractures accounted for 4.9% of patients in Caraceni's series; 0.2% were pelvic fractures. Patients may complain of a cracking sound followed by severe pain or just worsening pain exacerbated by movement or weight bearing.…”

Comparative Study Of Subarachnoid Calcitonin And Fentanyl As Adjuvant With Local Analgesic Bupivacaine For Postoperative Pain Relief: A Double Blind Study

“…This, probably, suggesting why in the present study patients with malignancy had considerably less pain in post operative period. Kalle et al (1999), Martinez et al(2003) Frauceschini R et al (1993) stated that the analgesic effect of salmon calcitonin occurs independently of its peripheral action. It has been postulated that administered calcitonin binds to its receptors located on neural elements, thereby affecting the analgesic pathway controlling pain perception or elevating the nociceptive sensitivity threshold.…”

Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases

“…Therefore, little information is available about its use in this context. However, Martinez et al (3) recently performed a systematic review of all the available data to determine the effectiveness of calcitonin in reducing metastatic bone pain. Unfortunately, only two studies (including only 90 patients in total) had the methodological quality required by the inclusion criteria.…”

“…No improvement in general performance or bone pain was detected as measured by a visual analogue scale, the daily duration of pain or consumption of analgesic drugs. The systematic review by Martinez et al (3) concluded that the available evidence was limited, did not support the use of calcitonin to control pain from bone metastases and called for new studies to provide additional information. It should be emphasized that this review did not include the randomised double-blind placebo-controlled clinical trial by Hindley et al (11) because a 4-week cut-off was a prerequisite for inclusion in the review, while the latter study was of two-week duration.…”

Update in Cancer Pain Syndromes

“…177 A Cochrane review concluded that the evidence was too limited to make a recommendation for the use of calcitonin. 178 Fractures Pathologic fractures accounted for 4.9% of patients in Caraceni's series; 0.2% were pelvic fractures. Patients may complain of a cracking sound followed by severe pain or just worsening pain exacerbated by movement or weight bearing.…”

Comparative Study Of Subarachnoid Calcitonin And Fentanyl As Adjuvant With Local Analgesic Bupivacaine For Postoperative Pain Relief: A Double Blind Study

“…This, probably, suggesting why in the present study patients with malignancy had considerably less pain in post operative period. Kalle et al (1999), Martinez et al(2003) Frauceschini R et al (1993) stated that the analgesic effect of salmon calcitonin occurs independently of its peripheral action. It has been postulated that administered calcitonin binds to its receptors located on neural elements, thereby affecting the analgesic pathway controlling pain perception or elevating the nociceptive sensitivity threshold.…”

Analgesic activity of high-dose intravenous calcitonin in cancer patients with bone metastases

“…Therefore, little information is available about its use in this context. However, Martinez et al (3) recently performed a systematic review of all the available data to determine the effectiveness of calcitonin in reducing metastatic bone pain. Unfortunately, only two studies (including only 90 patients in total) had the methodological quality required by the inclusion criteria.…”

“…No improvement in general performance or bone pain was detected as measured by a visual analogue scale, the daily duration of pain or consumption of analgesic drugs. The systematic review by Martinez et al (3) concluded that the available evidence was limited, did not support the use of calcitonin to control pain from bone metastases and called for new studies to provide additional information. It should be emphasized that this review did not include the randomised double-blind placebo-controlled clinical trial by Hindley et al (11) because a 4-week cut-off was a prerequisite for inclusion in the review, while the latter study was of two-week duration.…”

Update in Cancer Pain Syndromes

“…177 A Cochrane review concluded that the evidence was too limited to make a recommendation for the use of calcitonin. 178 Fractures Pathologic fractures accounted for 4.9% of patients in Caraceni's series; 0.2% were pelvic fractures. Patients may complain of a cracking sound followed by severe pain or just worsening pain exacerbated by movement or weight bearing.…”